Results 81 to 90 of about 28,925 (227)

dPNUTS binds to and co-localises with PP1 on chromosomes. [PDF]

, 2013
A) Predicted domain structure of dPNUTS and dPNUTS-S proteins, indicating the position of the putative PP1-binding motif (residues 722–726), which is located in the shortest yeast two-hybrid interacting clone (SIC) of dPNUTS. B) Beta-galactosidase assays
Andreii Rudenko (478708), Nick Lansdale (478706), Luke Alphey (28642), Anita Ciurciu (478704), Louise Duncalf (478705), Olga Vasieva (143513), Daimark Bennett (443583), Vincent Jonchere (443582), Emese Vissi (70126), Neville Cobbe (478709), Peter Glenday (478707)   +10 more
core   +1 more source

From Uncertainty to Pathogenicity: Resolving a CSF1R Variant of Uncertain Significance Using Long‐Read Transcriptomics

Movement Disorders, EarlyView.
Abstract Background CSF1R‐related disorder (CSF1R‐RD) is a severe autosomal dominant leukoencephalopathy characterized by progressive cognitive, neuropsychiatric, and motor decline. Although genetic testing is widely available, numerous likely pathogenic variants in CSF1R frequently remain classified as variants of uncertain significance (VUS ...
Charles Wade, Kylie Montgomery, Gabriela E. Jones, Peter Sellars, Akram A. Hosseini, Simon Paine, Henry Houlden, Mina Ryten, David S. Lynch   +8 more
wiley   +1 more source

Identification of broadly expressed nervous system‐related genes as effective RNAi targets in the brown marmorated stink bug, Halyomorpha halys

Pest Management Science, EarlyView.
Broadly expressed genes outperformed brain‐enriched neural targets as RNAi candidates in Halyomorpha halys. Microinjection of dsRNA targeting alpha‐soluble NSF attachment protein (Asnap) or Ras opposite protein (Rop) caused strong feeding suppression and near‐complete mortality, identifying them as promising targets for future oral or spray‐based RNAi ...
Nirakar Panda, Aline Koch, Venkata Partha Sarathi Amineni   +2 more
wiley   +1 more source

A PP1-binding motif present in BRCA1 plays a role in its DNA repair function

International Journal of Biological Sciences, 2008
Protein phosphatase 1α (PP1α) regulates phosphorylation of BRCA1, which contains a PP1-binding motif 898KVTF901. Mutation of this motif greatly reduces the interaction between BRCA1 and PP1α.
Young-Mi Yu, Serena M. Pace, Susan R. Allen, Chu-Xia Deng, Lih-Ching Hsu
doaj  

Numerically efficient mechanical modeling of reinforced concrete membrane elements with fixed, interlocked cracks

Structural Concrete, EarlyView.
Abstract Compression field approaches such as the Cracked Membrane Model with fixed, interlocked cracks (CMM‐F) are efficient tools for the mechanical modeling of reinforced concrete elements, providing the mechanical model σ=fε$$ \boldsymbol{\upsigma} =f\left(\boldsymbol{\upvarepsilon} \right) $$ required for finite element analyses.
Andreas Näsbom, Karel Thoma, Walter Kaufmann   +2 more
wiley   +1 more source

Emerging roles of the Protein Phosphatase 1 (PP1) in the context of viral infections

Cell Communication and Signaling
Protein Phosphatase 1 (PP1) is a major serine/threonine phosphatase in eukaryotes, participating in several cellular processes and metabolic pathways.
Pedro O. Corda, Mathieu Bollen, Daniela Ribeiro, Margarida Fardilha   +3 more
doaj   +1 more source

Actin dynamics tune the integrated stress response by regulating eukaryotic initiation factor 2α dephosphorylation

eLife, 2015
Four stress-sensing kinases phosphorylate the alpha subunit of eukaryotic translation initiation factor 2 (eIF2α) to activate the integrated stress response (ISR).
Joseph E Chambers, Lucy E Dalton, Hanna J Clarke, Elke Malzer, Caia S Dominicus, Vruti Patel, Greg Moorhead, David Ron, Stefan J Marciniak   +8 more
doaj   +1 more source

A role for PP1/NIPP1 in steering migration of human cancer cells. [PDF]

PLoS ONE, 2012
Electrical gradients are present in many developing and regenerating tissues and around tumours. Mimicking endogenous electric fields in vitro has profound effects on the behaviour of many cell types. Intriguingly, specific cell types migrate cathodally,
Cristina Martin-Granados, Alan R Prescott, Nele Van Dessel, Aleyde Van Eynde, Miguel Arocena, Izabela P Klaska, Janina Görnemann, Monique Beullens, Mathieu Bollen, John V Forrester, Colin D McCaig   +10 more
doaj   +1 more source

Cyanopeptide Mixtures Induce Variable Synergistic and Antagonistic Effects Across Diverse Human Cell Lines

Environmental Toxicology, EarlyView.
ABSTRACT Cyanobacterial harmful algal blooms (cyanoHABs) threaten human, animal, and ecosystem health and safety through production of toxic secondary metabolites. Microcystis, a cosmopolitan bloom‐forming cyanobacterial genus, is well‐known for producing hepatotoxic microcystins (MCs), but it can produce many other bioactive cyanopeptides, such as ...
Lauren N. Hart, Katherine L. Lev, Sierra Hefferan, Sanduni H. Premathilaka, Sharmila I. Thenuwara, Dragan Isailovic, David H. Sherman, Gregory J. Dick   +7 more
wiley   +1 more source

Taperin (c9orf75), a mutated gene in nonsyndromic deafness, encodes a vertebrate specific, nuclear localized protein phosphatase one alpha (PP1α) docking protein

Biology Open, 2012
Summary The promiscuous activity of protein phosphatase one (PP1) is controlled in the cell by associated proteins termed regulatory or targeting subunits.
Tony Ferrar, Delphine Chamousset, Veerle De Wever, Mhairi Nimick, Jens Andersen, Laura Trinkle-Mulcahy, Greg B. G. Moorhead   +6 more
doaj   +1 more source