Results 61 to 70 of about 28,925 (227)

SDS22 coordinates the assembly of holoenzymes from nascent protein phosphatase-1

Nature Communications
SDS22 forms an inactive complex with nascent protein phosphatase PP1 and Inhibitor-3. SDS22:PP1:Inhibitor-3 is a substrate for the ATPase p97/VCP, which liberates PP1 for binding to canonical regulatory subunits. The exact role of SDS22 in PP1-holoenzyme
Xinyu Cao, Madryn Lake, Gerd Van der Hoeven, Zander Claes, Javier del Pino García, Sarah Lemaire, Elora C. Greiner, Spyridoula Karamanou, Aleyde Van Eynde, Arminja N. Kettenbach, Daniel Natera de Benito, Laura Carrera García, Cristina Hernando Davalillo, Carlos Ortez, Andrés Nascimento, Roser Urreizti, Mathieu Bollen   +16 more
doaj   +1 more source

A PP1–PP2A phosphatase relay controls mitotic progression [PDF]

Nature, 2014
The widespread reorganization of cellular architecture in mitosis is achieved through extensive protein phosphorylation, driven by the coordinated activation of a mitotic kinase network and repression of counteracting phosphatases. Phosphatase activity must subsequently be restored to promote mitotic exit.
Grallert, A, Boke, E, Hagting, A, Hodgson, B, Connolly, Y, Griffiths, JR, Smith, DL, Pines, J, Hagan, Iain   +8 more
openaire   +3 more sources

Ocular and Systemic Findings in COL2A1 and COL11A1 Stickler Syndrome

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Stickler syndrome is most commonly caused by variants in COL2A1 and COL11A1 genes. The purpose of this study was to describe genetic variants and phenotypes in COL2A1 and COL11A1 Stickler syndrome. We performed a retrospective genotype–phenotype evaluation of COL2A1 and COL11A1 Stickler syndrome subjects. Thirty‐two subjects with COL2A1 and 13
Aileen G. MacLachlan, Jessica A. Kraker, Denise J. Morgan, Lisa A. Schimmenti, M. Elizabeth Hartnett, Eileen S. Hwang   +5 more
wiley   +1 more source

Light intensity-dependent arrestin switching for inactivation of a light-sensitive GPCR, bistable opsin

iScience
Summary: Inactivation of most light-sensitive G protein-coupled receptor (GPCR) opsins involves arrestin binding to terminate cell responses. In the zebrafish pineal organ, UV sensitive parapinopsin 1 (PP1)-expressing cells exhibit color opponency ...
Baoguo Shen, Seiji Wada, Tomohiro Sugihara, Takashi Nagata, Haruka Nishioka, Emi Kawano-Yamashita, Takeaki Ozawa, Mitsumasa Koyanagi, Akihisa Terakita   +8 more
doaj   +1 more source

Invisible Kitchens, Visible Values: Understanding Consumer Trust and Boundary Formation in Digital Food Experiences

Journal of Consumer Behaviour, EarlyView.
ABSTRACT This research investigates how consumers establish trust in ghost kitchens, a rapidly growing digital service format that eliminates physical interaction and redefines the boundaries of food consumption. Despite their growing popularity, ghost kitchens present a paradox of trust, as the absence of physical premises and direct interaction ...
Trang Huong Pham, Adriel K. S. Sim, Chuyen Nguyen, Julien Psomas, Hoang Ngoc Hien   +4 more
wiley   +1 more source

Displacement affinity chromatography of protein phosphatase one (PP1) complexes [PDF]

, 2008
Background. Protein phosphatase one (PP1) is a ubiquitously expressed, highly conserved protein phosphatase that dephosphorylates target protein serine and threonine residues.
Moorhead, Greg B. G., De Wever, Veerle, Veerle De Wever, Lamond, Angus I., Yun Lam, Lam, Yun Wah, Nimick, Mhairi, Gourlay, Robert, Lam, Yun W., Mhairi Nimick, David G Campbell, Lamond, Angus I.; id_orcid, Moorhead, Greg B.G., Angus I Lamond, Greg BG Moorhead, Laura Trinkle-Mulcahy, Robert Gourlay, Campbell, David G., Trinkle-Mulcahy, Laura   +18 more
core   +1 more source

Mapping the Protein Phosphatase 1 Interactome in Human Cytomegalovirus Infection

Viruses
Protein phosphorylation is a crucial regulatory mechanism in cellular homeostasis. The human cytomegalovirus (HCMV) incorporates protein phosphatase 1 (PP1) into its tegument, yet the biological relevance and mechanisms of this incorporation remain ...
Stefan Weinberger, Carmen Stecher, Marie-Theres Kastner, Sergei Nekhai, Christoph Steininger   +4 more
doaj   +1 more source

Clinical utility and genetic landscape of exome sequencing in a large pediatric epilepsy cohort: Insights from a Turkish tertiary care center

Epileptic Disorders, EarlyView.
Abstract Objective To evaluate the diagnostic utility and genetic spectrum of next‐generation sequencing (NGS) in a large, well‐phenotyped cohort of Turkish pediatric patients with epilepsy of unknown etiology. Methods Between January 2021 and December 2024, 250 children (115 female, 135 male) with unexplained epilepsy underwent either whole‐exome ...
Derya Karaer, Beste Kipçak Yüzbaşı, İpek Şahin, Olcay Güngör, Kadri Karaer   +4 more
wiley   +1 more source

Molecular architecture of the glycogen- committed PP1/PTG holoenzyme [PDF]

, 2022
The delicate alternation between glycogen synthesis and degradation is governed by the interplay between key regulatory enzymes altering the activity of glycogen synthase and phosphorylase.
Giachin, Gabriele, Covaceuszach, Sonia, Semrau, Marta Stefania, Storici, Paola, Cassetta, Alberto, Lolli, Graziano, Demitri, Nicola   +6 more
core   +1 more source

PNUTS/PP1 regulates RNAPII-mediated gene expression and is necessary for developmental growth. [PDF]

PLoS Genetics, 2013
In multicellular organisms, tight regulation of gene expression ensures appropriate tissue and organismal growth throughout development. Reversible phosphorylation of the RNA Polymerase II (RNAPII) C-terminal domain (CTD) is critical for the regulation ...
Anita Ciurciu, Louise Duncalf, Vincent Jonchere, Nick Lansdale, Olga Vasieva, Peter Glenday, Andreii Rudenko, Emese Vissi, Neville Cobbe, Luke Alphey, Daimark Bennett   +10 more
doaj   +1 more source