Results 41 to 50 of about 28,832 (233)

New pyrazolopyrimidine inhibitors of protein kinase d as potent anticancer agents for prostate cancer cells. [PDF]

PLoS ONE, 2013
The emergence of protein kinase D (PKD) as a potential therapeutic target for several diseases including cancer has triggered the search for potent, selective, and cell-permeable small molecule inhibitors.
Manuj Tandon, James Johnson, Zhihong Li, Shuping Xu, Peter Wipf, Qiming Jane Wang   +5 more
doaj   +1 more source

Protein Phosphatase 1 Regulates Human Cytomegalovirus Protein Translation by Restraining AMPK Signaling

Frontiers in Microbiology, 2021
Human cytomegalovirus (HCMV) carries the human protein phosphatase 1 (PP1) and other human proteins important for protein translation in its tegument layer for a rapid supply upon infection.
Carmen Stecher, Sanja Marinkov, Lucia Mayr-Harting, Ana Katic, Marie-Theres Kastner, Franz J. J. Rieder-Rommer, Xionghao Lin, Sergei Nekhai, Christoph Steininger   +8 more
doaj   +1 more source

Screening anticancer peptides performance in organotypic prostate tumor-stroma 3D models. [PDF]

Int J Cancer
What's new? Peptide‐based drugs have emerged as promising anticancer therapies for their potential to disrupt protein–protein interactions. In this study, the authors developed a physiomimetic human 3D prostate cancer spheroid model to assess the efficacy of the CAVPENET peptide in inhibiting tumor growth. Upon incubation with CAVPENET, prostate cancer
Matos B, Monteiro MV, Lagarto MR, Howl J, Jerónimo C, Gaspar VM, Mano JF, Fardilha M.   +7 more
europepmc   +2 more sources

A Phosphonic Acid Anchoring Analogue of the Sensitizer P1 for p-Type Dye-Sensitized Solar Cells

Crystals, 2018
We report the synthesis and characterization of the first example of an organic dye, PP1, for p-type dye-sensitized solar cells (DSCs) bearing a phosphonic acid anchoring group.
Y. Maximilian Klein, Nathalie Marinakis, Edwin C. Constable, Catherine E. Housecroft   +3 more
doaj   +1 more source

The Ki-67 and RepoMan mitotic phosphatases assemble via an identical, yet novel mechanism

eLife, 2016
Ki-67 and RepoMan have key roles during mitotic exit. Previously, we showed that Ki-67 organizes the mitotic chromosome periphery and recruits protein phosphatase 1 (PP1) to chromatin at anaphase onset, in a similar manner as RepoMan (Booth et al., 2014).
Ganesan Senthil Kumar, Ezgi Gokhan, Sofie De Munter, Mathieu Bollen, Paola Vagnarelli, Wolfgang Peti, Rebecca Page   +6 more
doaj   +1 more source

The human SKA complex drives the metaphase-anaphase cell cycle transition by recruiting protein phosphatase 1 to kinetochores

eLife, 2016
The spindle- and kinetochore-associated (Ska) complex is essential for normal anaphase onset in mitosis. The C-terminal domain (CTD) of Ska1 binds microtubules and was proposed to facilitate kinetochore movement on depolymerizing spindle microtubules ...
Sushama Sivakumar, Paweł Ł Janczyk, Qianhui Qu, Chad A Brautigam, P Todd Stukenberg, Hongtao Yu, Gary J Gorbsky   +6 more
doaj   +1 more source

Yeast Fin1-PP1 dephosphorylates an Ipl1 substrate, Ndc80, to remove Bub1-Bub3 checkpoint proteins from the kinetochore during anaphase.

PLoS Genetics, 2021
The spindle assembly checkpoint (SAC) prevents anaphase onset in response to chromosome attachment defects, and SAC silencing is essential for anaphase onset. Following anaphase onset, activated Cdc14 phosphatase dephosphorylates the substrates of cyclin-
Michael Bokros, Delaney Sherwin, Marie-Helene Kabbaj, Yanchang Wang   +3 more
doaj   +1 more source

PP1-6 ectopic expression restores stumpy formation in RBP7 null mutants.

, 2018
A. Inducible ectopic expression of PP1-6 in T. brucei EATRO 1125 AnTat1.1 90:13 parental cells (◼, +dox; ●, -dox) (*** pB. Inducible ectopic expression of PP1-6 in T.
Eleanor Silvester (4884406), Keith R. Matthews (199001), Binny M. Mony (5489153), Mathieu Cayla (631458), Kirsty McWilliam (5447576), Lindsay McDonald (5447573), Alasdair Ivens (33327), Paula MacGregor (198985)   +7 more
core   +1 more source

PP1-87B regulation of sister centromere fusion depends on microtubules.

, 2019
(A) Graph showing the spindle volume relative to the chromosome mass volume. The chromosome mass volumes remain constant while Pp1-87B RNAi oocytes (n = 31) had increased spindle volume compared to wild type (n = 22) oocytes.
Kim S. McKim (243877), Arunika Das (4918501), Lin-Ing Wang (223020)   +2 more
core   +1 more source

Switching on synaptic PP1 [PDF]

Journal of Cell Biology, 2013
![Figure][1] Immunogold EM shows inhibitor-2’s localization near the postsynaptic density (PSD) of a dendritic spine (sp). Hou et al. describe how neurons activate the protein phosphatase PP1 in response to synaptic stimulation.
openaire   +1 more source