Results 41 to 50 of about 28,925 (227)
The Ki-67 and RepoMan mitotic phosphatases assemble via an identical, yet novel mechanism
eLife, 2016 Ki-67 and RepoMan have key roles during mitotic exit. Previously, we showed that Ki-67 organizes the mitotic chromosome periphery and recruits protein phosphatase 1 (PP1) to chromatin at anaphase onset, in a similar manner as RepoMan (Booth et al., 2014).
Ganesan Senthil Kumar +6 more
doaj +1 more source
Structural Signature of the MYPT1−PP1 Interaction [PDF]
, 2016 Muscle relaxation is triggered by the dephosphorylation of Ser19 in the myosin regulatory light chain. This reaction is catalyzed by the holoenzyme myosin phosphatase (MP), which includes the catalytic subunit protein phosphatase 1 (PP1) and the ...
Anderson S. Pinheiro (1288788) +3 more
core +1 more source
PLoS Genetics, 2021 The spindle assembly checkpoint (SAC) prevents anaphase onset in response to chromosome attachment defects, and SAC silencing is essential for anaphase onset. Following anaphase onset, activated Cdc14 phosphatase dephosphorylates the substrates of cyclin-
Michael Bokros +3 more
doaj +1 more source
eLife, 2016 The spindle- and kinetochore-associated (Ska) complex is essential for normal anaphase onset in mitosis. The C-terminal domain (CTD) of Ska1 binds microtubules and was proposed to facilitate kinetochore movement on depolymerizing spindle microtubules ...
Sushama Sivakumar +6 more
doaj +1 more source
Pseudomonas syringae pv. pisi strain PP1 Annotation [PDF]
, 2019 Text files containing 1) P.syringae type III effector protein sequences in fasta format, and a file containing select toxin loci, used to query the PP1 genome 2) a file containing the results of type III effector annotation of strain PP1 3) a file ...
David Baltrus (449676)
core +1 more source
Switching on synaptic PP1 [PDF]
Journal of Cell Biology, 2013 ![Figure][1] Immunogold EM shows inhibitor-2’s localization near the postsynaptic density (PSD) of a dendritic spine (sp). Hou et al. describe how neurons activate the protein phosphatase PP1 in response to synaptic stimulation.
openaire +1 more source
The PP1 regulator PPP1R2 coordinately regulates AURKA and PP1 to control centrosome phosphorylation and maintain central spindle architecture [PDF]
BMC Molecular and Cell Biology, 2020 AbstractBackgroundMaintenance of centrosome number in cells is essential for accurate distribution of chromosomes at mitosis and is dependent on both proper centrosome duplication during interphase and their accurate distribution to daughter cells at cytokinesis.
Alan-Michael Bresch +3 more
openaire +2 more sources
Protein Phosphatase-1 Regulates Expression of Neuregulin-1
Biology, 2016 Protein phosphatase 1 (PP1), a cellular serine/threonine phosphatase, is targeted to cellular promoters by its major regulatory subunits, PP1 nuclear targeting subunit, nuclear inhibitor of PP1 (NIPP1) and RepoMan.
Tatiana Ammosova +7 more
doaj +1 more source
PP1 Cooperates with ASPP2 to Dephosphorylate and Activate TAZ [PDF]
Journal of Biological Chemistry, 2011 The Hippo pathway regulates organ size by controlling both cell proliferation and apoptosis. TAZ functions as a transcriptional co-activator downstream of the Hippo pathway and has been implicated in human cancer development. A key step in the Hippo-TAZ pathway is phosphorylation of TAZ by LATS kinase, which leads to TAZ inhibition by both cytoplasmic ...
Chen-Ying, Liu +8 more
openaire +2 more sources
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source