Results 31 to 40 of about 28,832 (233)
The nuclear envelope protein, LAP1B, is a novel protein phosphatase 1 substrate. [PDF]
PLoS ONE, 2013 Protein phosphatase 1 (PP1) binding proteins are quintessential regulators, determining substrate specificity and defining subcellular localization and activity of the latter.
Mariana Santos +7 more
doaj +1 more source
PP1-mediated dephosphorylation of phosphoproteins at mitotic exit is controlled by inhibitor-1 and PP1 phosphorylation [PDF]
Nature Cell Biology, 2009 Loss of cell division cycle 2 (Cdc2, also known as Cdk1) activity after cyclin B degradation is necessary, but not sufficient, for mitotic exit. Proteins phosphorylated by Cdc2 and downstream mitotic kinases must be dephosphorylated. We report here that protein phosphatase-1 (PP1) is the main catalyst of mitotic phosphoprotein dephosphorylation ...
Judy Qiju, Wu +7 more
openaire +2 more sources
Direct interaction between the catalytic subunit of Protein Phosphatase 1 and pRb
Cancer Cell International, 2006 Background The product of the retinoblastoma-susceptibility gene (pRb) is a substrate for Protein Phosphatase 1 (PP1). At mitotic exit, all three PP1 isoforms, α, γ1 and δ, bind to pRb and dephosphorylate its Ser/Thr sites in a sequential and site ...
Mittnacht Sibylle +4 more
doaj +1 more source
Protein phosphatase-1 activates CDK9 by dephosphorylating Ser175. [PDF]
PLoS ONE, 2011 The cyclin-dependent kinase CDK9/cyclin T1 induces HIV-1 transcription by phosphorylating the carboxyterminal domain (CTD) of RNA polymerase II (RNAPII).
Tatiana Ammosova +7 more
doaj +1 more source
International Journal of Biomedical Imaging, 2008 By plotting response times of young and older adults across a variety of tasks, Brinley spurred investigation and debate into the theory of general cognitive slowing.
Ann M. Peiffer +2 more
doaj +1 more source
Fgf8 regulates first pharyngeal arch segmentation through pouch-cleft interactions
Frontiers in Cell and Developmental Biology, 2023 Introduction: The pharyngeal arches are transient developmental structures that, in vertebrates, give rise to tissues of the head and neck. A critical process underlying the specification of distinct arch derivatives is segmentation of the arches along ...
Nathaniel Zbasnik, Jennifer L. Fish
doaj +1 more source
A Bitter PP1 Fights the Sweet Polo [PDF]
Molecular Cell, 2008 In a recent paper in Developmental Cell, Yamashiro et al. (2008) report that the PP1 regulatory subunit MYPT1 interacts with PLK1 and antagonizes essential mitotic functions of PLK1, at least in part by promoting the dephosphorylation of PLK1 at Thr210.
Archambault, Vincent +2 more
openaire +3 more sources
Repo-Man coordinates chromosomal reorganization with nuclear envelope reassembly during mitotic exit [PDF]
, 2011 This article is available open access under a Creative Commons license (http://creativecommons.org/licenses/by/3.0/). Copyright @ 2011 Elsevier Inc.Repo-Man targets protein phosphatase 1 γ (PP1γ) to chromatin at anaphase onset and regulates chromosome ...
Vagnarelli, Paola +31 more
core +1 more source
eLife, 2020 Collective cell migration is central to many developmental and pathological processes. However, the mechanisms that keep cell collectives together and coordinate movement of multiple cells are poorly understood. Using the Drosophila border cell migration
Yujun Chen +9 more
doaj +1 more source
Cell Biology: Polar Expeditions for PP1 [PDF]
Current Biology, 2013 A new study shows that phospho-dependent expulsion of type-1-phosphatase (PP1) from the spindle pole by Fin1 (NIMA) kinase ensures switch-like activation of Cyclin B-Cdk1 at the G2/M transition.
Meadows, John C. +1 more
openaire +2 more sources