Results 21 to 30 of about 28,832 (233)

Biotransformation Is an Effective Mechanism for Modulating the Biological Toxicity of Nodularin (NODR) [PDF]

Toxins
The biotransformation of nodularin (NOD) is one of the critical strategies for regulating their biological toxicity. To investigate the effects and mechanisms of the biotransformation pathway, this study synthesized six biotransformation products of ...
Chunyu Fu, Mengchen Li, Qiannan Shi, Yixue Xu, Wansong Zong   +4 more
doaj   +2 more sources

ASPPs multimerize protein phosphatase 1. [PDF]

PLoS Genetics
Protein Phosphatase 1 (PP1) activity is thought to be spatiotemporally defined by hundreds of different regulatory subunits, but their mechanisms of action are largely unknown.
Derek T Wei, Kayleigh N Morrison, Gwendolyn M Beacham, Erika Beyrent, Cyrus A Habas, Ying Zhang, Laurence Florens, Gunther Hollopeter   +7 more
doaj   +2 more sources

Structural and Functional Analysis of the GADD34:PP1 eIF2α Phosphatase

Cell Reports, 2015
The attenuation of protein synthesis via the phosphorylation of eIF2α is a major stress response of all eukaryotic cells. The growth-arrest- and DNA-damage-induced transcript 34 (GADD34) bound to the serine/threonine protein phosphatase 1 (PP1) is the ...
Meng S. Choy, Permeen Yusoff, Irene C. Lee, Jocelyn C. Newton, Catherine W. Goh, Rebecca Page, Shirish Shenolikar, Wolfgang Peti   +7 more
doaj   +3 more sources

The SDS22:PP1:I3 complex: SDS22 binding to PP1 loosens the active site metal to prime metal exchange

Journal of Biological Chemistry
SDS22 and Inhibitor-3 (I3) are two ancient regulators of protein phosphatase 1 (PP1) that regulate multiple essential biological processes. Both SDS22 and I3 form stable dimeric complexes with PP1; however, and atypically for PP1 regulators, they also form a triple complex, where both proteins bind to PP1 simultaneously (SPI complex).
Meng S Choy, Gautam Srivastava, Lucy C Robinson   +2 more
exaly   +3 more sources

Xenopus Cdc7 executes its essential function early in S phase and is counteracted by checkpoint-regulated protein phosphatase 1 [PDF]

Open Biology, 2014
The initiation of DNA replication requires two protein kinases: cyclin-dependent kinase (Cdk) and Cdc7. Although S phase Cdk activity has been intensively studied, relatively little is known about how Cdc7 regulates progression through S phase.
Wei Theng Poh, Gaganmeet Singh Chadha, Peter J. Gillespie, Philipp Kaldis, J. Julian Blow   +4 more
doaj   +1 more source

Small molecules targeted to a non-catalytic "RVxF" binding site of protein phosphatase-1 inhibit HIV-1. [PDF]

PLoS ONE, 2012
HIV-1 Tat protein recruits host cell factors including CDK9/cyclin T1 to HIV-1 TAR RNA and thereby induces HIV-1 transcription. An interaction with host Ser/Thr protein phosphatase-1 (PP1) is critical for this function of Tat. PP1 binds to a Tat sequence,
Tatiana Ammosova, Maxim Platonov, Venkat R K Yedavalli, Yuri Obukhov, Victor R Gordeuk, Kuan-Teh Jeang, Dmytro Kovalskyy, Sergei Nekhai   +7 more
doaj   +1 more source

PP1:Tautomycetin Complex Reveals a Path toward the Development of PP1-Specific Inhibitors [PDF]

Journal of the American Chemical Society, 2017
Selective inhibitors for each serine/threonine phosphatase (PPP) are essential to investigate the biological actions of PPPs and to guide drug development. Biologically diverse organisms (e.g., cyanobacteria, dinoflagellates, beetles) produce structurally distinct toxins that are catalytic inhibitors of PPPs.
Meng S. Choy, Mark Swingle, Brandon D’Arcy, Kevin Abney, Scott F. Rusin, Arminja N. Kettenbach, Rebecca Page, Richard E. Honkanen, Wolfgang Peti   +8 more
openaire   +2 more sources

Molecular basis for substrate specificity of the Phactr1/PP1 phosphatase holoenzyme

eLife, 2020
PPP-family phosphatases such as PP1 have little intrinsic specificity. Cofactors can target PP1 to substrates or subcellular locations, but it remains unclear how they might confer sequence-specificity on PP1.
Roman O Fedoryshchak, Magdalena Přechová, Abbey M Butler, Rebecca Lee, Nicola O'Reilly, Helen R Flynn, Ambrosius P Snijders, Noreen Eder, Sila Ultanir, Stephane Mouilleron, Richard Treisman   +10 more
doaj   +1 more source

Protein phosphatase-1 inhibitor-2 promotes PP1γ positive regulation of synaptic transmission

Frontiers in Synaptic Neuroscience, 2022
Inhibitor-2 (I-2) is a prototypic inhibitor of protein phosphatase-1 (PP1), a major serine-threonine phosphatase that regulates synaptic plasticity and learning and memory.
Karl Foley, Karl Foley, Haider Altimimi, Hailong Hou, Yu Zhang, Cody McKee, Cody McKee, Makaía M. Papasergi-Scott, Hongtian Yang, Abigail Mayer, Nancy Ward, David M. MacLean, Angus C. Nairn, David Stellwagen, Houhui Xia, Houhui Xia   +15 more
doaj   +1 more source

Mitotic ER exit site dynamics: insights into blockade of secretion from the ER during mitosis

Molecular & Cellular Oncology, 2020
How ER exit sites disassemble during mitosis is not well understood. Transport ANd Golgi Organization 1 (TANGO1, also known as MIA3), a cargo receptor originally identified for collagens, acts as a hub for ER exit site disassembly under the control of ...
Miharu Maeda, Yukie Komatsu, Kota Saito
doaj   +1 more source