PP1-6 ectopic expression restores stumpy formation in RBP7 null mutants. [PDF]
, 2018 A. Inducible ectopic expression of PP1-6 in T. brucei EATRO 1125 AnTat1.1 90:13 parental cells (◼, +dox; ●, -dox) (*** pB. Inducible ectopic expression of PP1-6 in T.
Eleanor Silvester (4884406) +7 more
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PP1-87B regulation of sister centromere fusion depends on microtubules. [PDF]
, 2019 (A) Graph showing the spindle volume relative to the chromosome mass volume. The chromosome mass volumes remain constant while Pp1-87B RNAi oocytes (n = 31) had increased spindle volume compared to wild type (n = 22) oocytes.
Kim S. McKim (243877) +2 more
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PP1-87B, SUR-8, and PER are in a protein complex. [PDF]
, 2019 aPP1-87b knockdown in circadian neurons lengthens circadian period. RNAi-1 (BL32414) expression in TD2 is lethal, but not in TUG (tim-UAS-GAL4, a relatively weaker driver). RNAi-2 indicates VDRC35025. Values inside bars indicate tested fly numbers. Error
Yongbo Xue (1523251) +2 more
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Direct interaction between the catalytic subunit of Protein Phosphatase 1 and pRb
Cancer Cell International, 2006 Background The product of the retinoblastoma-susceptibility gene (pRb) is a substrate for Protein Phosphatase 1 (PP1). At mitotic exit, all three PP1 isoforms, α, γ1 and δ, bind to pRb and dephosphorylate its Ser/Thr sites in a sequential and site ...
Mittnacht Sibylle +4 more
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The nuclear envelope protein, LAP1B, is a novel protein phosphatase 1 substrate. [PDF]
PLoS ONE, 2013 Protein phosphatase 1 (PP1) binding proteins are quintessential regulators, determining substrate specificity and defining subcellular localization and activity of the latter.
Mariana Santos +7 more
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PP1-mediated dephosphorylation of phosphoproteins at mitotic exit is controlled by inhibitor-1 and PP1 phosphorylation [PDF]
Nature Cell Biology, 2009 Loss of cell division cycle 2 (Cdc2, also known as Cdk1) activity after cyclin B degradation is necessary, but not sufficient, for mitotic exit. Proteins phosphorylated by Cdc2 and downstream mitotic kinases must be dephosphorylated. We report here that protein phosphatase-1 (PP1) is the main catalyst of mitotic phosphoprotein dephosphorylation ...
Judy Qiju, Wu +7 more
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PP1-87B antagonizes C(3)G to regulate sister centromere fusion. [PDF]
, 2019 (A) Confocal images of oocytes expressing c(3)G RNAi in combination with Pp1-87B or Spc105R RNAi. The centromeres are shown in red in the merged images. Scale bar = 5 μm. (B) Dot plot showing the number of centromere foci in (A).
Kim S. McKim (243877) +2 more
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Protein phosphatase-1 activates CDK9 by dephosphorylating Ser175. [PDF]
PLoS ONE, 2011 The cyclin-dependent kinase CDK9/cyclin T1 induces HIV-1 transcription by phosphorylating the carboxyterminal domain (CTD) of RNA polymerase II (RNAPII).
Tatiana Ammosova +7 more
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Fgf8 regulates first pharyngeal arch segmentation through pouch-cleft interactions
Frontiers in Cell and Developmental Biology, 2023 Introduction: The pharyngeal arches are transient developmental structures that, in vertebrates, give rise to tissues of the head and neck. A critical process underlying the specification of distinct arch derivatives is segmentation of the arches along ...
Nathaniel Zbasnik, Jennifer L. Fish
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PP1-87B regulates chromosome alignment through lateral attachment and co-orientation via end-on attachment. [PDF]
, 2019 (A) Confocal images of Pp1-87B RNAi oocytes when expressing Spc105R RNAi or Ndc80 RNAi. Centromeres are in white, DNA is in blue and tubulin is in green. Single channel image is selected to show DNA in the merge images. Error bars = 5μm.
Kim S. McKim (243877) +2 more
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