Results 51 to 60 of about 28,925 (227)

The extended PP1 toolkit: designed to create specificity [PDF]

Trends in Biochemical Sciences, 2010
Protein Ser/Thr phosphatase-1 (PP1) catalyzes the majority of eukaryotic protein dephosphorylation reactions in a highly regulated and selective manner. Recent studies have identified an unusually diversified PP1 interactome with the properties of a regulatory toolkit.
Mathieu, Bollen, Wolfgang, Peti, Michael J, Ragusa, Monique, Beullens   +3 more
openaire   +2 more sources

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

The pp60c-Src inhibitor PP1 is non-competitive against ATP [PDF]

, 2003
Glutathione-S-transferase (GST)-pp60c-Src (GST-Src) expressed in Escherichia coli is as catalytically active as purified, activated pp60c-Src protein derived from human platelets.
Sarit Mizrachi, Aviv Gazit, Alexander Levitzki, Reiss-Sklan, Ella, Levitzki, Alexander, Mizrachi, Sarit, Gazit, Aviv, Rotem Karni, Livnah, Oded, Oded Livnah, Karni, Rotem, Ella Reiss-Sklan   +11 more
core   +1 more source

Towards understanding substrate recruitment by PP1 holophosphatases [PDF]

, 2023
Protein phosphorylation is a vital regulatory mechanism within the cell which is commonly dysregulated in diseases such as cancer and neurodegeneration.

core   +1 more source

PDZ-directed substrate recruitment is the primary determinant of specific 4E-BP1 dephosphorylation by PP1-Neurabin

eLife
Phosphoprotein phosphatase 1 (PP1) relies on association with PP1-interacting proteins (PIPs) to generate substrate-specific PIP/PP1 holoenzymes, but the lack of well-defined substrates has hindered elucidation of the mechanisms involved.
Roman O Fedoryshchak, Karim El-Bouri, Dhira Joshi, Stephane Mouilleron, Richard Treisman   +4 more
doaj   +1 more source

The Plant‐to‐Plant Circular Strategy: Coupling Photodegradation and Phytoremediation With Plant‐Based Nanomaterials for Plastic Degradation

Advanced Science, EarlyView.
Plant‐based nanomaterials derived from alfalfa serve as dual‐function catalysts, coupling photodegradation and phytoremediation to degrade polyethylene under UV‐A light and in soil. The nanomaterials work synergistically with alfalfa and soil microbes, achieving efficient plastic breakdown without trophic transfer.
Haoran Liu, Lena Ciric, Yuheng Wang, Ziru Pei, Manpreet Bhatti   +4 more
wiley   +1 more source

DNA of pp1 and EFCIV583 are packaged in separated capsids. [PDF]

, 2013
Presentation of two working hypotheses for pp1 and EFCIV583 DNA packaging in a dilysogen strain and experimental results corroborating one of them. On the left, DNAs are packaged inside the same capsid. The resulting virions are predicted to deliver both
Laurent Debarbieux (356004), Nicolas Lapaque (74962), Thierry Meylheuc (113058), Lionel Rigottier-Gois (191709), Francis Repoila (25002), Bruno Gonzalez-Zorn (191795), Maria de Fatima Lopes (5655058), Renata C. Matos (191731), Pascale Serror (191801)   +8 more
core   +1 more source

A Novel NR3C1 Frameshift Variant Associated With Familial Glucocorticoid Resistance Syndrome: An Integrated Analysis of Steroid Profiling and Structural Modeling

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Glucocorticoid resistance syndrome (GRS) is a rare hereditary disorder caused by pathogenic variants in NR3C1, characterized by marked phenotypic heterogeneity and frequent misdiagnosis as primary aldosteronism or subclinical Cushing's syndrome.
Sufang Yun, Zhifeng Zhu, Fengye Zhou, Ying Liu, Chunfang Liang, Haitao Ju, Lin Lu, Zhaoli Yan   +7 more
wiley   +1 more source

Interaction between E. faecalis pp1 and pp7 (EfCIV583). [PDF]

, 2013
(A) Semi-quantitative PCR detection of EfCIV583 circular forms (attP) and excision sites (attB) in wild-type (WT) and strains pp1−, pp1+ pp7+ and pp7+.
Laurent Debarbieux (356004), Nicolas Lapaque (74962), Thierry Meylheuc (113058), Lionel Rigottier-Gois (191709), Francis Repoila (25002), Bruno Gonzalez-Zorn (191795), Maria de Fatima Lopes (5655058), Renata C. Matos (191731), Pascale Serror (191801)   +8 more
core   +1 more source

Protein phosphatase 1 and memory: practice makes PP1 imperfect? [PDF]

, 2003
Long-lasting memories are most efficiently formed by multiple training sessions separated by appropriately timed intervals. A recent study revealed that expression of a transgene encoding an inhibitor of protein phosphatase 1 (PP1) in the forebrain ...
Waddell, S, Waddell, Scott
core   +3 more sources