Results 1 to 10 of about 1,152 (97)

PPA2 Deficiency in 2 Sisters [PDF]

JACC: Case Reports, 2023
Inorganic pyrophosphatase 2 (PPA2) deficiency is a genetic cause of sudden cardiac death, often triggered by viral infection or alcohol consumption. Literature on management is limited because most cases are diagnosed post mortem.
Bruce D. Gelb, Veronica Fettig
exaly   +4 more sources

SIRT5-mediated desuccinylation of PPA2 enhances HIF-1alpha-dependent adaptation to hypoxic stress and colorectal cancer metastasis [PDF]

EMBO Journal
Metastasis is the primary cause of death in patients with colorectal cancer (CRC). Hypoxia is a hallmark of solid tumors that promotes cellular metabolic adaptation and dissemination. However, the mechanisms linking hypoxia-regulated metabolic adaptation
Yu-Qin Di, Zunfu Ke, Weiling He
exaly   +3 more sources

Sudden unexpected death in asymptomatic infants due to PPA2 variants

Molecular Genetics & Genomic Medicine, 2020
Background Sudden death in children is a tragic event that often remains unexplained after comprehensive investigation. We report two asymptomatic siblings who died unexpectedly at approximately 1 year of age found to have biallelic (compound ...
Laura Gould, David B Goldstein, Matthew Halvorsen   +2 more
exaly   +2 more sources

Multi-omics pan-cancer analysis reveals the prognostic values and immunological functions of PPA2, with a spotlight on breast cancer [PDF]

Frontiers in Immunology
BackgroundRecently, the role of inorganic pyrophosphatase 2 (PPA2) has been remaining merely superficial in many tumors. Hence, the aim was to analyze the potential functions of PPA2 in pan-cancer, focusing on its role in breast cancer.MethodsA ...
Jia-Ning Zhang, Jia-Ning Zhang, Jia-Ning Zhang, Bei-Bei Yang, Bei-Bei Yang, Bei-Bei Yang, Lin-Wei Li, Lin-Wei Li, Lin-Wei Li, Hao Xu, Hao Xu, Hao Xu, Bin Wang, Bin Wang, Bin Wang, Zi-Lu Yi, Zi-Lu Yi, Zi-Lu Yi, Xi-Rui Zhou, Xi-Rui Zhou, Xi-Rui Zhou, Hong Liu, Hong Liu, Hong Liu   +23 more
doaj   +2 more sources

Growth Performance, Health Parameters, and Blood Metabolites of Dairy Calves Supplemented with a Polyherbal Phytogenic Additive [PDF]

Animals
This study aimed to evaluate the effects of dietary supplementation with increasing levels of a polyherbal phytogenic additive (PPA) on growth performance, health parameters, and blood metabolites of dairy calves.
Lucero Abigail Velázquez-Cruz, German David Mendoza-Martínez, Pedro Abel Hernández-García, Enrique Espinosa-Ayala, Cesar Díaz-Galván, Gabriela Vázquez-Silva, José Felipe Orzuna-Orzuna, Pablo Benjamín Razo-Ortíz, María Eugenia de la Torre-Hernández   +8 more
doaj   +2 more sources

Molecular identification and phylogenetic profiling of African swine fever virus in Indonesia during 2021–2025 based on the B646L (p72) gene [PDF]

Veterinary World
Background and Aim: African swine fever (ASF) is a highly contagious and often fatal viral disease of domestic pigs caused by African swine fever virus (ASFV), posing a serious threat to global swine production and food security.
Muharam Saepulloh, Ni Luh Putu Indi Dharmayanti, Aswin Rafif Khairullah, Harimurti Nuradji, Wiwiek Tyasningsih, Atik Ratnawati, Mustofa Helmi Effendi, Indrawati Sendow, Budiastuti Budiastuti, Susanti Susanti, Dian Ayu Permatasari, Saifur Rehman   +11 more
doaj   +2 more sources

A ratiometric catalog of protein isoform shifts in the cardiac fetal gene program [PDF]

JCI Insight
Pathological cardiac remodeling is associated with the reactivation of fetal genes, yet the extent of the heart’s fetal gene program and its impact on proteome compositions remain incompletely understood.
Yu Han, Shaonil Binti, Sara A. Wennersten, Boomathi Pandi, Dominic C.M. Ng, Edward Lau, Maggie P.Y. Lam   +6 more
doaj   +2 more sources

Balancing between cuproplasia and copper-dependent cell death: molecular basis and clinical implications of ATOX1 in cancer [PDF]

Journal of Experimental & Clinical Cancer Research
Human antioxidant protein 1 (ATOX1) is an essential regulator of copper homeostasis in cells. By interacting with other proteins involved in controlling the intracellular levels of cuprous ions (Cu+), ATOX1 contributes to the import, export, and ...
Justyna Suwara, Mariusz L. Hartman
doaj   +2 more sources

Partial correlation network analysis identifies coordinated gene expression within a regional cluster of COPD genome-wide association signals. [PDF]

PLoS Computational Biology
Chronic obstructive pulmonary disease (COPD) is a complex disease influenced by well-established environmental exposures (most notably, cigarette smoking) and incompletely defined genetic factors.
Michele Gentili, Kimberly Glass, Enrico Maiorino, Brian D Hobbs, Zhonghui Xu, Peter J Castaldi, Michael H Cho, Craig P Hersh, Dandi Qiao, Jarrett D Morrow, Vincent J Carey, John Platig, Edwin K Silverman   +12 more
doaj   +2 more sources

Association and shared biological bases between birth weight and cortical structure [PDF]

Translational Psychiatry
Associations between birth weight and cortical structural phenotypes have been detected; however, the understanding is incomprehensive, and the potential biological bases are not well defined.
Lu Zhang, Qiaoyue Ge, Zeyuan Sun, Rui Zhang, Xinxi Li, Xiaoli Luo, Run Tian, Yuheng Cao, Chunyan Pu, Lin Li, Dongsheng Wu, Ping Jiang, Chuan Yu, Chiara Nosarti, Chenghan Xiao, Zhenmi Liu   +15 more
doaj   +2 more sources