The P2 receptor antagonist PPADS supports recovery from experimental stroke in vivo. [PDF]
PLoS ONE, 2011 BACKGROUND: After ischemia of the CNS, extracellular adenosine 5'-triphosphate (ATP) can reach high concentrations due to cell damage and subsequent increase of membrane permeability. ATP may cause cellular degeneration and death, mediated by P2X and P2Y
Alexandra B Lämmer +9 more
doaj +8 more sources
Structural insights into the orthosteric inhibition of P2X receptors by non-ATP analog antagonists [PDF]
eLifeP2X receptors are extracellular ATP-gated ion channels that form homo- or heterotrimers and consist of seven subtypes. They are expressed in various tissues, including neuronal and nonneuronal cells, and play critical roles in physiological processes ...
Danqi Sheng +7 more
doaj +3 more sources
Topical application of PPADS inhibits complement activation and choroidal neovascularization in a model of age-related macular degeneration. [PDF]
PLoS ONE, 2013 Age-related macular degeneration (AMD) is the most common cause of blindness among the elderly. AMD patients have elevated levels of membrane attack complex (MAC) in their choroidal blood vessels and retinal pigment epithelium (RPE).
Kerstin Birke +3 more
doaj +2 more sources
Candidalysin Is the Hemolytic Factor of Candida albicans [PDF]
Toxins, 2022 Candida albicans produces an important virulence factor, the hypha-associated Ece1-derived secreted peptide toxin candidalysin, which is crucial for the establishment of mucosal and systemic infections. C.
Selene Mogavero +11 more
doaj +2 more sources
P2 receptor antagonist PPADS inhibits mesangial cell proliferation in experimental mesangial proliferative glomerulonephritis [PDF]
Kidney International, 2002 BACKGROUND Although extracellular nucleotides have been shown to confer mitogenic effects in cultured rat mesangial cells through activation of purinergic P2 receptors (P2Y receptors), thus far the in vivo relevance of these findings is unclear ...
Sylvia Rost +5 more
openalex +2 more sources
Molecular mechanisms of extracellular-ATP-mediated colorectal cancer progression: Implication of purinergic receptors-mediated nucleocytoplasmic shuttling of HuR. [PDF]
Purinergic SignalOne of the leading causes of cancer-related deaths worldwide is colorectal cancer (CRC). Extracellular ATP (e-ATP) and purinergic receptors (P2R) play a central role in CRC proliferation and progression.
Shatat AS +4 more
europepmc +2 more sources
Suramin, an antiparasitic drug, stimulates adipocyte differentiation and promotes adipogenesis [PDF]
Lipids in Health and Disease, 2023 Background Previous studies demonstrated that mast cells with their degranulated component heparin are the major endogenous factors that stimulate preadipocyte differentiation and promote fascial adipogenesis, and this effect is related to the structure ...
Hanxiao Li +7 more
doaj +2 more sources
Prevention of M2 polarization and temporal limitation of differentiation in monocytes by extracellular ATP [PDF]
BMC Immunology, 2023 Background Elevated levels of extracellular adenosine triphosphate (ATP) modulate immunologic pathways and are considered to be a danger signal in inflammation, lung fibrosis and cancer.
Benedikt F. Scherr +8 more
doaj +2 more sources
PPADS does not block contraction-induced prostaglandin E2synthesis in cat skeletal muscle
American Journal of Physiology. Heart and Circulatory Physiology, 2008 Pyridoxal-phosphate-6-azophenyl-2'-4-disulfonate (PPADS), a purinergic 2 (P2) receptor antagonist, has been shown to attenuate the exercise pressor reflex in cats. In vitro, however, PPADS has been shown to block the production of prostaglandins, some of
Jennifer L. McCord +2 more
openalex +3 more sources
The P2 receptor antagonist PPADS abrogates LPS-induced neutrophil migration in the murine air pouch via inhibition of MIP-2 and KC production [PDF]
Molecular Immunology, 2009 Filip Kukulski +5 more
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