The P2 receptor antagonist PPADS supports recovery from experimental stroke in vivo. [PDF]
PLoS ONE, 2011 BACKGROUND: After ischemia of the CNS, extracellular adenosine 5'-triphosphate (ATP) can reach high concentrations due to cell damage and subsequent increase of membrane permeability. ATP may cause cellular degeneration and death, mediated by P2X and P2Y
Alexandra B Lämmer +9 more
doaj +7 more sources
Structural insights into the orthosteric inhibition of P2X receptors by non-ATP analog antagonists [PDF]
eLifeP2X receptors are extracellular ATP-gated ion channels that form homo- or heterotrimers and consist of seven subtypes. They are expressed in various tissues, including neuronal and nonneuronal cells, and play critical roles in physiological processes ...
Danqi Sheng +7 more
doaj +3 more sources
Topical application of PPADS inhibits complement activation and choroidal neovascularization in a model of age-related macular degeneration. [PDF]
PLoS ONE, 2013 Age-related macular degeneration (AMD) is the most common cause of blindness among the elderly. AMD patients have elevated levels of membrane attack complex (MAC) in their choroidal blood vessels and retinal pigment epithelium (RPE).
Kerstin Birke +3 more
doaj +2 more sources
Mapping the binding site of the P2X receptor antagonist PPADS reveals the importance of orthosteric site charge and the cysteine-rich head region [PDF]
Journal of Biological Chemistry, 2018 ATP is the native agonist for cell-surface ligand-gated P2X receptor (P2XR) cation channels. The seven mammalian subunits (P2X1–7) form homo- and heterotrimeric P2XRs having significant physiological and pathophysiological roles.
Hong Huo +4 more
semanticscholar +2 more sources
Extracellular ATP triggers proteolysis and cytosolic Ca2+ rise in
Malaria Journal, 2012 Background Plasmodium has a complex cell biology and it is essential to dissect the cell-signalling pathways underlying its survival within the host. Methods Using the fluorescence resonance energy transfer (FRET) peptide substrate Abz-AIKFFARQ-EDDnp and
Cruz Laura +6 more
doaj +6 more sources
Activation of Piezo1 and TRPV4 channels contributes to hCMEC/D3 cell mechano-sensing [PDF]
Frontiers in PhysiologyIntroductionTRPV4 and Piezo1 channels have been considered two important mechanical sensors. To examine the role of these two channels in blood brain barrier (BBB) mechano-sensing, the expression and function of TRPV4 and PIEZO1 in hCMEC/D3, an in vitro ...
Wenhan An +6 more
doaj +2 more sources
Contractions of ex-vivo mouse bladder driven by activation of channelrhodopsin-2 expressed in urothelial cells [PDF]
Scientific ReportsSignaling molecules released from the urothelium by mechanical stretch are known to play a sensory role in bladder contractions via neuronal signaling.
Firoj Alom +3 more
doaj +2 more sources
Molecular mechanisms of extracellular-ATP-mediated colorectal cancer progression: Implication of purinergic receptors-mediated nucleocytoplasmic shuttling of HuR. [PDF]
Purinergic SignalOne of the leading causes of cancer-related deaths worldwide is colorectal cancer (CRC). Extracellular ATP (e-ATP) and purinergic receptors (P2R) play a central role in CRC proliferation and progression.
Shatat AS +4 more
europepmc +2 more sources
Prevention of M2 polarization and temporal limitation of differentiation in monocytes by extracellular ATP [PDF]
BMC Immunology, 2023 Background Elevated levels of extracellular adenosine triphosphate (ATP) modulate immunologic pathways and are considered to be a danger signal in inflammation, lung fibrosis and cancer.
Benedikt F. Scherr +8 more
doaj +2 more sources
Suramin, an antiparasitic drug, stimulates adipocyte differentiation and promotes adipogenesis [PDF]
Lipids in Health and Disease, 2023 Background Previous studies demonstrated that mast cells with their degranulated component heparin are the major endogenous factors that stimulate preadipocyte differentiation and promote fascial adipogenesis, and this effect is related to the structure ...
Hanxiao Li +7 more
doaj +2 more sources