Results 91 to 100 of about 5,154 (256)
Molecular Microbiology, Volume 123, Issue 6, Page 569-585, June 2025.Porphyromonas gingivalis exports several virulent proteins, including gingipain proteinases, via the type 9 secretion system. Expression of several T9SS component proteins is regulated by the PorA‐PorY‐PoX‐SigP signaling cascade. This study presents a novel role of PorA in the signaling cascade.
Momoko Ito +9 more
wiley +1 more source
Detrusor overactivity induced by intravesical application of adenosine 5 '-triphosphate under different delivery conditions in rats [PDF]
, 2005 Objectives. We investigate the effects of intravesical application of adenosine 5'-triphosphate (ATP) on bladder activity to elucidate the role of urothelial barrier function and ecto-ATPase activity in the ATP-mediated mechanism inducing detrusor ...
Barbacci +33 more
core +1 more source
A P2X receptor-mediated nociceptive afferent pathway to lamina I of the spinal cord
Molecular Pain, 2005 Of the six lamina regions in the dorsal horn of the spinal cord, lamina I is a major sensory region involved in nociceptive transmission under both physiological and pathological conditions.
Gu Jianguo G, Chen Meng
doaj +1 more source
Aggregate, Volume 6, Issue 5, May 2025.Pathogen‐derived extracellular vesicle detection: theoretical insights and advanced methodologies: This review explores the theoretical foundations and practical applications of pEV detection, emphasizing the challenges and innovative strategies involving novel aggregate materials and machine learning for enhanced diagnostic accuracy.
Lihan Lai +6 more
wiley +1 more source
Anti-Hu antibodies activate enteric and sensory neurons. [PDF]
, 2016 IgG of type 1 anti-neuronal nuclear antibody (ANNA-1, anti-Hu) specificity is a serological marker of paraneoplastic neurological autoimmunity (including enteric/autonomic) usually related to small-cell lung carcinoma. We show here that IgG isolated from
A Hormigo +44 more
core +2 more sources
P2X-Receptor Antagonists Inhibit the Interaction of S. aureus Hemolysin A with Membranes
Toxins, 2017 The pore forming hemolysin A, Hla, is a major virulence factor of Staphylococcus aureus. Apparently, 1–2 pore(s) per cell suffice(s) to cause cell death.
Markus Schwiering +2 more
doaj +1 more source
Role of P2X7R in Retinal Diseases: A Review
Immunity, Inflammation and Disease, Volume 13, Issue 5, May 2025.ABSTRACT Background P2X purinoceptor 7 receptor (P2X7R) is an ATP‐gated ion channel that, upon activation by ATP, triggers the release of inflammatory mediators and induces apoptosis in cells. This channel plays a crucial role in the onset and progression of various diseases.
Chunli Li, Binsheng Wang
wiley +1 more source
Citrullination mediated by PPAD constrains biofilm formation in P. gingivalis strain 381 [PDF]
npj Biofilms and Microbiomes, 2019 AbstractPorphyromonas gingivalis is the only known human-associated prokaryote that produces a peptidylarginine deiminase (PPAD), a protein-modifying enzyme that is secreted along with a number of virulence factors via a type IX secretion system (T9SS). While the function of PPAD in P.
Danielle M. Vermilyea +2 more
openaire +2 more sources
TRPV3 in keratinocytes transmits temperature information to sensory neurons via ATP [PDF]
, 2009 Transient receptor potential V3 (TRPV3) and TRPV4 are heat-activated cation channels expressed in keratinocytes. It has been proposed that heat-activation of TRPV3 and/or TRPV4 in the skin may release diffusible molecules which would then activate ...
Ardem Patapoutian +9 more
core +2 more sources
Journal of Enzyme Inhibition and Medicinal Chemistry, 2019 New anticancer agents are highly needed to overcome cancer cell resistance. A novel series of pyrimidine pyrazoline-anthracene derivatives (PPADs) (4a-t) were designed and synthesised. The anti-liver cancer activity of all compounds was screened in vitro
Naglaa Mohamed Ahmed +3 more
doaj +1 more source