Results 91 to 100 of about 5,261 (261)

Suramin inhibits antibody binding to cell surface antigens and disrupts complement-mediated mesangial cell lysis

Journal of Pharmacological Sciences, 2016
Suramin inhibits immune responses and protects cells against inflammatory cell injury. However, little is known about its mechanisms. Using an in vitro model of glomerular mesangial cell (MC) lysis induced by antibodies plus complement, we investigated ...
Honglan Piao, Yuan Chi, Xiling Zhang, Zhen Zhang, Kun Gao, Manabu Niimi, Manabu Kamiyama, Jinming Zhang, Masayuki Takeda, Jian Yao   +9 more
doaj   +1 more source

Autoimmunity and Periodontitis

Journal of Periodontal Research, EarlyView.
In a microbe‐driven inflammatory environment, peptidyl‐arginine deiminase (PAD) enzymes from neutrophils and Porphyromonas gingivalis citrullinate both microbial and self‐antigens. B cell presentation of citrullinated or self‐mimicking epitopes activates T cells that assist B cells in antibody isotype switching, affinity maturation, epitope spreading ...
Massimo Costalonga, Vivek Thumbigere‐Math, Mark C. Herzberg   +2 more
wiley   +1 more source

Periodontitis and rheumatoid arthritis—Global efforts to untangle two complex diseases

Periodontology 2000, EarlyView.
Abstract Understanding the impact of oral health on rheumatoid arthritis (RA) will inform how best to manage patients with both periodontitis and RA. This review seeks to provide an update on interventional and mechanistic investigations, including a brief summary of European Research programs investigating the link between periodontitis and RA. Recent
Isabel Lopez‐Oliva, Jennifer Malcolm, Shauna Culshaw   +2 more
wiley   +1 more source

Role for astroglia-derived BDNF and MSK1 in homeostatic synaptic plasticity [PDF]

, 2018
Homeostatic scaling of synaptic strength in response to environmental stimuli may underlie the beneficial effects of an active lifestyle on brain function.
Bogdanov, Alexander, Frenguelli, Bruno G., Lalo, Ulyana, Moss, Guy W. J., Pankratov, Yuriy   +4 more
core   +1 more source

Role of S1P‐ and Rho‐kinase signalling in age‐related myogenic tone deficiency in murine resistance arteries

Experimental Physiology, EarlyView.
Abstract Ageing is a risk factor for cardiovascular and neurodegenerative diseases. The myogenic response in resistance arteries is responsible for basal (myogenic) tone and blood flow autoregulation. G‐protein‐coupled receptors and G12/RhoA/Rho kinase are implicated in myogenic tone (MT), and we aimed to clarify their role in pressure sensing and ...
Gry Freja Skovsted, Alex Aupetit, Karl Björling, Kristian Agmund Haanes, Susanne Syberg, Niklas Rye Jørgensen, Blanca I. Aldana, Hirotsugu Tsuchimochi, Mark T. Waddingham, Kristine Freude, James Todd Pearson, Lars Jørn Jensen   +11 more
wiley   +1 more source

Design, synthesis, molecular modelling, and biological evaluation of novel substituted pyrimidine derivatives as potential anticancer agents for hepatocellular carcinoma

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
New anticancer agents are highly needed to overcome cancer cell resistance. A novel series of pyrimidine pyrazoline-anthracene derivatives (PPADs) (4a-t) were designed and synthesised. The anti-liver cancer activity of all compounds was screened in vitro
Naglaa Mohamed Ahmed, Mahmoud Youns, Moustafa Khames Soltan, Ahmed Mohammed Said   +3 more
doaj   +1 more source

A P2X receptor-mediated nociceptive afferent pathway to lamina I of the spinal cord

Molecular Pain, 2005
Of the six lamina regions in the dorsal horn of the spinal cord, lamina I is a major sensory region involved in nociceptive transmission under both physiological and pathological conditions.
Gu Jianguo G, Chen Meng
doaj   +1 more source

P2X4 receptor function in the nervous system and current breakthroughs in pharmacology [PDF]

, 2017
ATP is a well-known extracellular signalling molecule and neurotransmitter known to activate purinergic P2X receptors. Information has been elucidated about the structure and gating of P2X channels following the determination of the crystal structure of ...
Abdelrahman, Acuna-Castillo, Agresti, Allsopp, Amadio, Antonio, Asatryan, Asatryan, Asatryan, Ase, Balazs, Banke, Bardoni, Basbaum, Baxter, Bernier, Bhattacharya, Biber, Bintig, Bo, Bobanovic, Boumechache, Bowler, Browne, Buell, Burnstock, Burnstock, Cao, Cardoso, Cham, Chung, Clarke, Coddou, Coddou, Coddou, Cohen, Coull, Davies, de Rivero Vaccari, Di Virgilio, DiSabato, Dixon, Egan, Farber, Ferrini, Fischer, Franke, Franklin, Franklin, Fumagalli, Gao, Garcia-Guzman, Gofman, Gofman, Guo, Hattori, He, Hernandez-Olmos, Horvath, Horvath, Huang, Huynh, Idzko, Igawa, Inoue, Ito, Jabs, Jarvis, Jelinkova, Jo, Joers, Jones, Kawate, Kerr, Kettenmann, Khakh, Khakh, Khakh, Khakh, Khakh, Khoja, Kimpel, Kobayashi, Krause, Krůšek, Kukley, Laing, Lalo, Lalo, Le, Li, Li, Li, Luo, Lê, Mapplebeck, Masuda, Matsumura, Miklavc, Miller, Nagata, Nasu-Tada, Neher, Nicke, North, Nörenberg, Oesterle, Ostrovskaya, Ousingsawat, Ozaki, Pelegrin, Popova, Popova, Potula, Priel, Qureshi, Ransohoff, Raouf, Robinson, Rokic, Royle, Rubio, Saijo, Samways, Samways, Sathanoori, Saul, Schwab, Shinozaki, Shrivastava, Silberberg, Sim, Sim, Sorge, Soto, Soto, Stojilkovic, Stojilkovic, Stokes, Stokes, Surprenant, Tan, Tian, Toulme, Toulme, Toulme, Toyomitsu, Trang, Tsuda, Tsuda, Tsuda, Tsuda, Tsuda, Tsuda, Ulmann, Ulmann, Ulmann, Vavra, Vazquez-Villoldo, Virginio, Wes, Wheeler-Schilling, Wildman, Wixey, Wyatt, Wyatt, Xiong, Xu, Yamamoto, Yamamoto, Yamashita, Yang, Yardley, Zarei, Zemkova   +174 more
core   +2 more sources

The Association Between Serum Immunoglobulin G Titers Against Porphyromonas gingivalis and Chronic Kidney Disease in Patients With Rheumatoid Arthritis and Periodontitis: A Retrospective Cohort Study

Clinical and Experimental Dental Research, Volume 12, Issue 1, February 2026.
ABSTRACT Objectives Chronic kidney disease (CKD) is relatively common in patients with rheumatoid arthritis (RA). Periodontitis and periodontopathic Porphyromonas gingivalis are risk factors for CKD. However, the association of serum immunity to P. gingivalis and its peptidylarginine deiminase (PPAD), as well as periodontitis severity, with CKD in ...
Tetsuo Kobayashi, Satoshi Ito, Noriko Sugita, Akira Murasawa, Hajime Ishikawa, Koichi Tabeta   +5 more
wiley   +1 more source

PPAD -completeness of polyhedral versions of Sperner’s Lemma

Discrete Mathematics, 2013
Abstract We show that certain polyhedral versions of Sperner’s Lemma, where the colouring is given explicitly as part of the input, are PPAD -complete. The proofs are based on two recent results on the complexity of computational problems in game theory: the PPAD -completeness of 2-player Nash, proved by Chen and Deng, and of Scarf’s Lemma, proved ...
Király, Tamás, Pap, Júlia
openaire   +1 more source