Results 111 to 120 of about 5,154 (256)

P2X₃ Knock-Out Mice Reveal a Major Sensory Role for Urothelially Released ATP [PDF]

, 2001
The present study explores the possible involvement of a purinergic mechanism in mechanosensory transduction in the bladder using P2X₃ receptor knock-out (P2X₃ ⁻⁄⁻) and wild-type control (P2X₃ ⁺⁄⁺) mice.
Bardini, M, Bodin, P, Burnstock, G, Cockayne, DA, Ford, APDW, Kasakov, L, Rong, W, Vlaskovska, M   +7 more
core  

A Physiologic Role for Serotonergic Transmission in Adult Rat Taste Buds [PDF]

, 2014
Data Availability: The authors confirm that all data underlying the findings are fully available without restriction. All relevant data are within the paper.Partial funding for Open Access provided by The Ohio State University Open Access Fund.Of the ...
Herness, Scott, Jaber, Luc, Kolli, Tamara, Zhao, Fang-li   +3 more
core   +2 more sources

Connection between oral health and chronic diseases

MedComm, Volume 6, Issue 1, January 2025.
Mechanisms linking oral health to chronic diseases. The figure highlights oral health connections to diabetes, cardiovascular diseases, rheumatoid arthritis, and respiratory diseases. Key mechanisms include inflammation, microbial dysbiosis, oxidative stress, and immune dysregulation, emphasizing the systemic impacts of oral diseases like periodontitis.
Di Fu, Xingyue Shu, Ge Zhou, Mengzhen Ji, Ga Liao, Ling Zou   +5 more
wiley   +1 more source

P2X7 receptors induce degranulation in human mast cells. [PDF]

, 2016
Mast cells play important roles in host defence against pathogens, as well as being a key effector cell in diseases with an allergic basis such as asthma and an increasing list of other chronic inflammatory conditions.
A Lundequist, A Surprenant, AG Driver, AM Gilfillan, AS Kirshenbaum, AW Hauswirth, B Hechler, C Feng, CE Owen, D Ferrari, DM Manthei, E Shigetomi, Elizabeth P. Seward, ES Schulman, F Jacob, F Virgilio Di, G Barbara, G Buell, G Burnstock, G Burnstock, H Saito, J Capite Di, JM Brown, JP Bennett, K Mulryan, K Wareham, Kathryn J. Wareham, M Idzko, M Idzko, M Vig, MA McCloskey, MG Rolf, N Sudo, OK Basoglu, PE Tatham, R Dahlquist, R Dahlquist, RC Wykes, RJ Evans, SR Holdsworth, TM Egan, Y Kurashima, Y Osipchuk, ZG Gao   +43 more
core   +1 more source

Periodontal pathogens and cancer development

Periodontology 2000, Volume 96, Issue 1, Page 112-149, October 2024.
Abstract Increasing evidence suggests a significant association between periodontal disease and the occurrence of various cancers. The carcinogenic potential of several periodontal pathogens has been substantiated in vitro and in vivo. This review provides a comprehensive overview of the diverse mechanisms employed by different periodontal pathogens in
Yuxi Zhou, Joerg Meyle, Sabine Groeger
wiley   +1 more source

P2X4 forms functional ATP-activated cation channels on lysosomal membranes regulated by luminal pH. [PDF]

, 2014
P2X receptors are commonly known as plasma membrane cation channels involved in a wide variety of cell functions. The properties of these channels have been extensively studied on the plasma membrane. However, studies in amoeba suggest that P2X receptors
Brailoiu, Burnstock, Calcraft, Chataigneau, Clarke, Dong, Dong, Dong, Dou, Fountain, Graves, Guo, Haanes, Hattori, Holtzman, Huynh, Kexin Zhao, Khakh, Lange, Lloyd-Evans, Michael X. Zhu, Miklavc, Mindell, Morgan, Nilsson, North, Pankratov, Parkinson, Patel, Peng Huang, Priel, Qi Cao, Qureshi, Royle, Ruth Murrell-Lagnado, Sawada, Silberberg, Sivaramakrishnan, Steinberg, Sumoza-Toledo, Xi Zoë Zhong, Xian-Ping Dong, Yuanjie Zou, Zalk, Zhang   +44 more
core   +2 more sources

Circadian ATP Release in Organotypic Cultures of the Rat Suprachiasmatic Nucleus Is Dependent on P2X7 and P2Y Receptors

Frontiers in Pharmacology, 2018
The circadian rhythms in physiological and behavioral functions are driven by a pacemaker located in the suprachiasmatic nucleus (SCN). The rhythms continue in constant darkness and depend on cell-cell communication between neurons and glia.
Irena Svobodova, Anirban Bhattaracharya, Milorad Ivetic, Zdenka Bendova, Hana Zemkova   +4 more
doaj   +1 more source

An atlas and database of neuropeptide gene expression in the adult zebrafish forebrain

Journal of Comparative Neurology, Volume 532, Issue 6, June 2024.
An expression atlas and database of 38 neuropeptide genes and GABAergic/glutamatergic neuron marker genes in the adult zebrafish forebrain were constructed. The zebrafish hypothalamus was subdivided into finer subregions and its organization was reassessed based on the profiles of neuropeptide expression.
Towako Hiraki‐Kajiyama, Nobuhiko Miyasaka, Reiko Ando, Noriko Wakisaka, Hiroya Itoga, Shuichi Onami, Yoshihiro Yoshihara   +6 more
wiley   +1 more source

Genetic and immune identification and functional analysis of TRPM8 as a potential biomarker for pancreatic adenocarcinoma proliferation

Cancer Reports, Volume 7, Issue 6, June 2024.
Abstract Background Pancreatic adenocarcinoma (PAAD), a member of highly lethal malignant tumors, has a poor outcome and extremely poor prognosis. The transient receptor potential (TRP) superfamily, a group of nonselective cation channels, is capable of influencing cellular functions by regulating calcium homeostasis.
Sen Qiao, Fengming Wu, Hongmei Wang
wiley   +1 more source

Experimental inhibition of proliferative retinopathy [PDF]

, 2012
Retinal ischemic diseases like retinopathy of prematurity (ROP), diabetic retinopathy (DRP) and retinal vein occlusion, with preretinal neovascularization (angiogenesis) that may lead to vitreous hemorrhages and retinal detachment with subsequent vision ...
Almlöf Sarman, Sylvia
core   +1 more source