Results 121 to 130 of about 5,154 (256)

P2Y11 Purinoceptor Mediates the ATP-Enhanced Chemotactic Response of Rat Neutrophils

Journal of Pharmacological Sciences, 2012
ATP and hydrolysis products of ATP like adenosine regulate the chemotaxis of neutrophils by activating purinoceptors and adenosine receptors. The present study was designed to examine exogenous ATP, activation of purinoceptors, and activation of A3 ...
Feras Alkayed, Masanori Kashimata, Noriko Koyama, Toru Hayashi, Yasuo Tamura, Yukio Azuma   +5 more
doaj  

Extracellular ATP inhibits excitatory synaptic input on parvalbumin positive interneurons and attenuates gamma oscillations via P2X4 receptors

British Journal of Pharmacology, Volume 181, Issue 11, Page 1635-1653, June 2024.
Abstract Background and Purpose P2X4 receptors (P2X4R) are ligand gated cation channels that are activated by extracellular ATP released by neurons and glia. The receptors are widely expressed in the brain and have fractional calcium currents comparable with NMDA receptors.
Florian Wildner, Tim S. Neuhäusel, Alexander Klemz, Richard Kovács, Lauriane Ulmann, Jörg R. P. Geiger, Zoltan Gerevich   +6 more
wiley   +1 more source

P2Y receptors in the mammalian nervous system: pharmacology, ligands and therapeutic potential [PDF]

, 2012
P2Y receptors for extracellular nucleotides are coupled to activation of a variety of G proteins and stimulate diverse intracellular signaling pathways that regulate functions of cell types that comprise the central nervous system (CNS).
Erb, Laurie, Seye, Cheik I., Weisman, Gary A., Woods, Lucas T.   +3 more
core   +1 more source

P2Y Receptor-Mediated Ca2+ Signaling Increases Human Vascular Endothelial Cell Permeability

Journal of Pharmacological Sciences, 2004
We investigated the effects of P2-receptor agonists on cell size, intracellular calcium levels ([Ca2+]i), and permeation of FITC-labeled dextran (FD-4) as well as the relationship between these effects in human umbilical vein endothelial cells (HUVEC ...
Naoko Tanaka, Kumiko Kawasaki, Namie Nejime, Yoko Kubota, Kazuki Nakamura, Masaru Kunitomo, Koichi Takahashi, Michio Hashimoto, Kazumasa Shinozuka   +8 more
doaj  

Review of: "TLR2 Activation by Porphyromonas gingivalis Requires Both PPAD Activity and Fimbriae" [PDF]

, 2022
Dongmei Zhang
openalex   +1 more source

Sex and size shape the ontogeny of partial migration

Journal of Animal Ecology, Volume 93, Issue 4, Page 406-416, April 2024.
This study shows that migratory phenotypic expression—migrant or resident—in a long‐lived, partially‐migrant raptor is associated with interactive effects of age, sex and body size, that the transition to residence is largely directional with age, and that migratory phenotype can have direct fitness consequences. Abstract The arrival‐time hypothesis of
Stephanie Witczak, Urs Kormann, Michael Schaub, Steffen Oppel, Martin U. Grüebler   +4 more
wiley   +1 more source

Blocking connexin43 hemichannels protects mice against tumour necrosis factor-induced inflammatory shock [PDF]

, 2019
Upon intravenous injection of tumour necrosis factor (TNF) in mice, a systemic inflammatory response syndrome (SIRS) is initiated, characterized by an acute cytokine storm and induction of vascular hyperpermeability.
Czekaj, Aleksandra, De Smet, Maarten, Declercq, Wim, Decrock, Elke, Delvaeye, Tinneke, Gonçalves, Amanda, Krysko, Dmitri, Lemeire, Kelly, Leybaert, Luc, Vandenabeele, Peter, Vandenbroucke, Roosmarijn, Verwaerde, Stijn   +11 more
core   +2 more sources

Hemolysis in human erythrocytes by Clostridium perfringens epsilon toxin requires activation of P2 receptors

Virulence, 2018
Epsilon-toxin (ETX) is produced by types B and D strains of Clostridium perfringens, which cause fatal enterotoxaemia in sheep, goats and cattle. Previous studies showed that only a restricted number of cell lines are sensitive to ETX and ETX-induced ...
Jie Gao, Wenwen Xin, Jing Huang, Bin Ji, Shan Gao, Liang Chen, Lin Kang, Hao Yang, Xin Shen, Baohua Zhao, Jinglin Wang   +10 more
doaj   +1 more source

Inspiratory and sigh breathing rhythms depend on distinct cellular signalling mechanisms in the preBötzinger complex

The Journal of Physiology, Volume 602, Issue 5, Page 809-834, 1 March 2024.
Abstract figure legend Schematic diagram summarizing the mechanisms of intracellular Ca2+ oscillations and how they generate the sigh rhythm. The larger blue circle represents the neuron, while the smaller interior green compartment indicates a Ca2+‐sequestering organelle such as the ER.
Daniel S. Borrus, Marco K. Stettler, Cameron J. Grover, Eva J. Kalajian, Jeffrey Gu, Gregory D. Conradi Smith, Christopher A. Del Negro   +6 more
wiley   +1 more source

Cell cycle regulation of astrocytes by extracellular nucleotides and fibroblast growth factor-2 [PDF]

, 2005
Extracellular ATP enhances the mitogenic activity of fibroblast growth factor-2 (FGF2) in astrocytes, but the molecular mechanism underlying this synergistic interaction is not known.
BF King, C Ho, CJ Gallagher, CJ Marshall, CJ Sherr, D Ferrari, D Schiffer, D Wang, F Doetsch, F Eclancher, F Perraud, FP Gendron, FP Gendron, G Burnstock, G Lenz, G Lenz, GL Peterson, H Franke, J Silver, JB Cavanagh, JD Weber, JJ Yang, JL Ridet, Joseph T. Neary, JT Neary, JT Neary, JT Neary, JT Neary, JT Neary, K Roovers, M Fumagalli, MC Jacques-Silva, MP Abbracchio, MP Rathbone, N Huang, N Latov, NE Olson, OR Baricordi, P Zanovello, Q Zhu, QB She, R Seger, RM Tombes, RS Ostrom, SJ Hill-Felberg, SP Finklestein, UK Laemmli, V Budagian, W Panenka, WT Norton, Y Nakatsuji, Y Takamiya, YJ Hou, You-Fang Shi, Yuan Kang   +54 more
core   +2 more sources