Results 141 to 150 of about 5,154 (256)

Purinerg receptorok által közvetített hatások komplex vizsgálata: új neuroprotektív terápiás lehetőségek elméleti alapjai = Complex studies on purinergic receptor-mediated actions: a theoretical basis for neuroprotection [PDF]

, 2006
Vizsgálataink fő célja a neurotranszmitter felszabadulást serkentő P2 nukleotid receptorok szerepének tisztázása volt fiziológiás és patológiás állapotokban. Feltérképeztük a P2X7 receptort kódoló mRNS eloszlását a központi idegrendszer számos területén.
Baranyi, Mária, Gerevich, Zoltán, Köfalvi, Attila, Sperlágh, Beáta, Vizi E., Szilveszter   +4 more
core  

Cannabinoid receptors contribute to astroglial Ca2+-signalling and control of synaptic plasticity in the neocortex [PDF]

, 2014
Communication between neuronal and glial cells is thought to be very important for many brain functions. Acting via release of gliotransmitters, astrocytes can modulate synaptic strength.
Lalo, Ulyana, Palygin, Oleg, Pankratov, Yuriy, Rasooli-Nejad, Seyed   +3 more
core   +1 more source

Salt-Sensitive Signaling Networks in the Mediation of K+/Na+ Homeostasis Gene Expression in Glycyrrhiza uralensis Roots

Frontiers in Plant Science, 2017
We investigated the effects of salt-sensitive signaling molecules on ionic fluxes and gene expression related to K+/Na+ homeostasis in a perennial herb, Glycyrrhiza uralensis, during short-term NaCl stress (100 mM, 24 h).
Tao Lang, Shurong Deng, Shurong Deng, Nan Zhao, Chen Deng, Yinan Zhang, Yanli Zhang, Huilong Zhang, Gang Sa, Jun Yao, Caiwu Wu, Yanhong Wu, Qun Deng, Shanzhi Lin, Jianxin Xia, Shaoliang Chen   +15 more
doaj   +1 more source

Fast Ca2+ Transients of Inner Hair Cells Arise Coupled and Uncoupled to Ca2+ Waves of Inner Supporting Cells in the Developing Mouse Cochlea

Frontiers in Molecular Neuroscience, 2018
Before the onset of hearing, which occurs around postnatal day 12 (P12) in mice, inner hair cells (IHCs) of the immature cochlea generate sound-independent Ca2+ action potentials (APs), which stimulate the auditory pathway and guide maturation of ...
Tobias Eckrich, Kerstin Blum, Ivan Milenkovic, Jutta Engel   +3 more
doaj   +1 more source

NPY mediates ATP-induced neuroproliferation in adult mouse olfactory epithelium

Neurobiology of Disease, 2010
In the CNS, ATP is released upon injury and promotes neuroproliferation via purinergic receptors. In the olfactory epithelium, ATP promotes the synthesis and release of neurotrophic factor NPY in neonates and induces neuroproliferation in neonatal and ...
Cuihong Jia, Colleen Cosgrove Hegg
doaj  

The Ionotropic P2X4 Receptor has Unique Properties in the Heart by Mediating the Negative Chronotropic Effect of ATP While Increasing the Ventricular Inotropy

Frontiers in Pharmacology, 2019
Background: Mounting evidence indicate that reducing the sinoatrial node (SAN) activity may be a useful therapeutic strategy to control of heart failure.
Bruno Bragança, Bruno Bragança, Sílvia Nogueira-Marques, Fátima Ferreirinha, Ana Patrícia Fontes-Sousa, Paulo Correia-de-Sá   +5 more
doaj   +1 more source

Mechanisms of constitutive and ATP-evoked ATP release in neonatal mouse olfactory epithelium

BMC Neuroscience, 2012
Background ATP is an extracellular signaling molecule with many ascribed functions in sensory systems, including the olfactory epithelium. The mechanism(s) by which ATP is released in the olfactory epithelium has not been investigated.
Hayoz Sébastien, Jia Cuihong, Hegg CC
doaj   +1 more source

P2X receptor trafficking in neurons is subunit specific [PDF]

, 2002
P2X receptors within the CNS mediate excitatory synaptic transmission and also act presynaptically to modulate neurotransmitter release. We have studied the targeting and trafficking of P2X4 and P2X2 receptors heterologously expressed in cultured ...
Bobanovic, Laura K, Murrell-Lagnado, Ruth D, Royle, Stephen J   +2 more
core   +3 more sources

Selective stimulation of catecholamine release from bovine adrenal chromaffin cells by an ionotropic purinergic receptor sensitive to 2-methylthio ATP

BMC Neuroscience, 2007
Background 2-Methylthioadenosine 5'-triphosphate (2-MeSATP), formerly regarded as a specific P2Y (metabotropic) purinergic receptor agonist, stimulates Ca2+ influx and evokes catecholamine release from adrenal chromaffin cells.
Castro Enrique, Tomé Ângelo R, Santos Rosa M, Rosário Luís M   +3 more
doaj   +1 more source

Synthetic antimicrobial and LPS-neutralising peptides suppress inflammatory and immune responses in skin cells and promote keratinocyte migration [PDF]

, 2016
The stagnation in the development of new antibiotics and the concomitant high increase of resistant bacteria emphasize the urgent need for new therapeutic options.
Brandenburg, Klaus, Gutsmann, Thomas, Heinbockel, Lena, Pfalzgraff, Anja, Su, Qi, Weindl, Günther   +5 more
core   +1 more source