Pure-Circuit: Strong Inapproximability for PPAD [PDF]
2022 IEEE 63rd Annual Symposium on Foundations of Computer Science (FOCS), 2022 The current state-of-the-art methods for showing inapproximability in PPAD arise from the ε-Generalized-Circuit (ε-GCircuit) problem. Rubinstein (2018) showed that there exists a small unknown constant ε for which ε-GCircuit is PPAD-hard, and subsequent work has shown hardness results for other problems in PPAD by using ε-GCircuit as an intermediate ...
Argyrios Deligkas +3 more
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Cloned and transfected P2Y4 receptors: characterization of a suramin and PPADS‐insensitive response to UTP [PDF]
British Journal of Pharmacology, 1996 Steven J. Charlton +5 more
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Inhibitory action of PPADS on relaxant responses to adenine nucleotides or electrical field stimulation in guinea‐pig taenia coli and rat duodenum [PDF]
British Journal of Pharmacology, 1995 Ursula Windscheif +7 more
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PPAD is not targeted as a citrullinated protein in rheumatoid arthritis, but remains a candidate for inducing autoimmunity [PDF]
Annals of the Rheumatic Diseases, 2014 We thank Dr Quirke and colleagues for their interest in our study. We have some concerns, however, that the authors’ attempt to reconcile our work on Porphyromonas gingivalis peptidylarginine deiminase (PPAD) autocitrullination with their model of periodontal disease in rheumatoid arthritis (RA) misrepresents our data.1 ,2 The discovery that ...
Maximilian F. Konig +2 more
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PPADS selectively antagonizes P2X‐purinoceptor‐mediated responses in the rabbit urinary bladder [PDF]
British Journal of Pharmacology, 1993 А. У. Зиганшин +6 more
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Co‐existence of P2Y‐ and PPADS‐insensitive P2U‐purinoceptors in endothelial cells from adrenal medulla [PDF]
British Journal of Pharmacology, 1996 Jesús Mateo +2 more
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TLR2 Activation by Porphyromonas gingivalis Requires Both PPAD Activity and Fimbriae [PDF]
Frontiers in Immunology, 2022 Porphyromonas gingivalis, a keystone oral pathogen implicated in development and progression of periodontitis, may also contribute to the pathogenicity of diseases such as arthritis, atherosclerosis, and Alzheimer’s. P. gingivalis is a master manipulator of host immune responses due to production of a large variety of virulence factors. Among these, P.
Aleksandra Wielento +6 more
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, 2008 Scarf's lemma is one of the fundamental results in combinatorics, originally introduced to study the core of an N-person game. Over the last four decades, the usefulness of Scarf's lemma has been demonstrated in several important combinatorial problems seeking "stable" solutions.
Shiva Kintali
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Discrimination by PPADS between endothelial P2Y‐ and P2U‐ purinoceptors in the rat isolated mesenteric arterial bed [PDF]
British Journal of Pharmacology, 1996 Vera Ralevic, Geoffrey Burnstock
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Tree Polymatrix Games are PPAD-hard [PDF]
, 2020 We prove that it is PPAD-hard to compute a Nash equilibrium in a tree polymatrix game with twenty actions per player. This is the first PPAD hardness result for a game with a constant number of actions per player where the interaction graph is acyclic. Along the way we show PPAD-hardness for finding an $ $-fixed point of a 2D LinearFIXP instance, when
Argyrios Deligkas +2 more
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