Results 51 to 60 of about 5,261 (261)

P2X1 and P2X5 subunits form the functional P2X receptor in mouse cortical astrocytes [PDF]

, 2008
ATP plays an important role in signal transduction between neuronal and glial circuits and within glial networks. Here we describe currents activated by ATP in astrocytes acutely isolated from cortical brain slices by non-enzymatic mechanical ...
Kirchhoff, Frank, Lalo, Ulyana, North, R. Alan, Pankratov, Yuriy, Rossner, Moritz J., Verkhratskiĭ, A. N. (Alekseĭ Nestorovich), Wichert, Sven P.   +6 more
core   +1 more source

Extracellular ATP Increases Glucose Metabolism in Skeletal Muscle Cells in a P2 Receptor Dependent Manner but Does Not Contribute to Palmitate-Induced Insulin Resistance

Frontiers in Physiology, 2020
Saturated fatty acids such as palmitate contribute to the development of Type 2 Diabetes by reducing insulin sensitivity, increasing inflammation and potentially contributing to anabolic resistance. We hypothesized that palmitate-induced ATP release from
Ana Miguel Cruz, Craig Beall
doaj   +1 more source

Activation of retinal glial (Müller) cells by extracellular ATP induces pronounced increases in extracellular H+ flux. [PDF]

PLoS ONE, 2018
Small alterations in extracellular acidity are potentially important modulators of neuronal signaling within the vertebrate retina. Here we report a novel extracellular acidification mechanism mediated by glial cells in the retina. Using self-referencing
Boriana K Tchernookova, Chad Heer, Marin Young, David Swygart, Ryan Kaufman, Michael Gongwer, Lexi Shepherd, Hannah Caringal, Jason Jacoby, Matthew A Kreitzer, Robert Paul Malchow   +10 more
doaj   +1 more source

P2X receptors: epithelial ion channels and regulators of salt and water transport. [PDF]

, 2008
When the results from electrophysiological studies of renal epithelial cells are combined with data from in vivo tubule microperfusion experiments and immunohistochemical surveys of the nephron, the accumulated evidence suggests that ATP-gated ion ...
Brian F. King, Bucheimer RE, Dai LJ, Dubyak GR, Egan TM, Inscho EW, King BF, Lazarowski ER, Lazarowski ER, Lehrmann H, Leipziger J, Li L, McCoy DE, North RA, Pelegrin P, Piper AS, Ralevic V, Schwiebert EM, Scott S.P. Wildman, Shirley DG, Taylor AL, Unwin RJ, Vekaria R, Wildman SS, Wildman SS, Wildman SS, Wildman SS, Wildman SS, Wolff SC, Zhang Y   +29 more
core   +1 more source

Purinergic mechanosensory transduction and visceral pain [PDF]

, 2009
In this review, evidence is presented to support the hypothesis that mechanosensory transduction occurs in tubes and sacs and can initiate visceral pain.
Burnstock, G
core   +3 more sources

PPAD: a deep learning architecture to predict progression of Alzheimer’s disease

Bioinformatics, 2023
Abstract Motivation Alzheimer’s disease (AD) is a neurodegenerative disease that affects millions of people worldwide. Mild cognitive impairment (MCI) is an intermediary stage between cognitively normal state and AD. Not all people who have MCI convert to AD.
Mohammad Al Olaimat, Jared Martinez, Fahad Saeed, Serdar Bozdag   +3 more
openaire   +4 more sources

Possible neuroprotective role of P2X2 in the retina of diabetic rats

Diabetology & Metabolic Syndrome, 2018
Background Purinergic receptors are expressed in different tissues including the retina. These receptors are involved in processes like cell growth, proliferation, activation and survival. ATP is the major activator of P2 receptors. In diabetes, there is
Jorge E. Mancini, Gustavo Ortiz, Constanza Potilinstki, Juan P. Salica, Emiliano S. Lopez, J. Oscar Croxatto, Juan E. Gallo   +6 more
doaj   +1 more source

Release of ATP in the ventral medulla during hypoxia in rats: role in hypoxic ventilatory response [PDF]

, 2005
P2X2 receptor subunits of the ATP-gated ion channels are expressed by physiologically identified respiratory neurons in the ventral respiratory column, implicating ATP in the control of respiratory activity.
Dale, Nicholas, Gourine, Alexander V., Llaudet, Enrique, Spyer, K. Michael   +3 more
core   +2 more sources

Pure-Circuit: Tight Inapproximability for PPAD

Journal of the ACM
The current state-of-the-art methods for showing inapproximability in PPAD arise from the ɛ-Generalized-Circuit (ɛ- GCircuit ) problem. Rubinstein (2018) showed that there exists a small unknown constant ɛ for which ɛ- GCircuit is PPAD -hard ...
Argyrios Deligkas, John Fearnley, Alexandros Hollender, Themistoklis Melissourgos   +3 more
openalex   +6 more sources

ATP signaling in the integrative neural center of Aplysia californica

Scientific Reports, 2021
ATP and its ionotropic P2X receptors are components of the most ancient signaling system. However, little is known about the distribution and function of purinergic transmission in invertebrates.
János Györi, Andrea B. Kohn, Daria Y. Romanova, Leonid L. Moroz   +3 more
doaj   +1 more source