Urothelial cells have been implicated in bladder mechanosensory transduction, and thus, initiation of the micturition reflex. Cell deformation caused by tension forces at an air-liquid interface (ALI) can induce an increase in intracellular Ca2 ...
Jiliang Wen+7 more
doaj +1 more source
Purinergic mechanosensory transduction and visceral pain [PDF]
In this review, evidence is presented to support the hypothesis that mechanosensory transduction occurs in tubes and sacs and can initiate visceral pain.
Burnstock, G
core +3 more sources
Small alterations in the level of extracellular H+ can profoundly alter neuronal activity throughout the nervous system. In this study, self-referencing H+-selective microelectrodes were used to examine extracellular H+ fluxes from individual astrocytes.
Ji-in Vivien Choi+13 more
doaj +1 more source
Resetting intrinsic purinergic modulation of neural activity: an associative mechanism? [PDF]
The purines, ATP and adenosine, control the rundown and termination of swimming in the Xenopus embryo. This intrinsic purinergic modulation, unavoidably present during every swimming episode, could lead to stereotyped inflexible behavior and consequently
Dale, Nicholas
core +1 more source
Investigation of the functional expression of purine and pyrimidine receptors in porcine isolated pancreatic arteries [PDF]
Receptors for purines and pyrimidines are expressed throughout the cardiovascular system. This study investigated their functional expression in porcine isolated pancreatic arteries.
Alsaqati, M.+2 more
core +3 more sources
The Rainbow at the End of the Line — A PPAD Formulation of the Colorful Carathéodory Theorem with Applications [PDF]
38 pages, 2 ...
Frédéric Meunier+3 more
openalex +4 more sources
Constant rank bimatrix games are PPAD-hard [PDF]
The rank of a bimatrix game (A,B) is defined as rank(A+B). Computing a Nash equilibrium (NE) of a rank-$0$, i.e., zero-sum game is equivalent to linear programming (von Neumann'28, Dantzig'51). In 2005, Kannan and Theobald gave an FPTAS for constant rank games, and asked if there exists a polynomial time algorithm to compute an exact NE.
openaire +3 more sources
Purinergic P2 receptors trigger adenosine release leading to adenosine A2A receptor activation and facilitation of long-term potentiation in rat hippocampal slices [PDF]
Electrophysiological recordings were used to investigate the effects of ATP analogues on [theta]-burst-induced long-term potentiation (LTP) in rat hippocampal slices.
Almeida, T.+4 more
core +1 more source
Fiat-Shamir for Repeated Squaring with Applications to PPAD-Hardness and VDFs [PDF]
The Fiat-Shamir transform is a methodology for compiling a (public-coin) interactive proof system for a language L into a non-interactive argument system for L. Proving security of the Fiat-Shamir transform in the standard model, especially in the context of succinct arguments, is largely an unsolved problem. The work of Canetti et al.
Vinod Vaikuntanathan, Alex Lombardi
openaire +3 more sources
Delegation with Updatable Unambiguous Proofs and PPAD-Hardness [PDF]
In this work, we construct an updatable and unambiguous delegation scheme based on the decisional assumption on bilinear groups introduced by Kalai, Paneth and Yang [STOC 2019]. Using this delegation scheme, we show PPAD-hardness (and hence the hardness of computing Nash equilibria) based on the quasi-polynomial hardness of this bilinear group ...
Omer Paneth+2 more
openaire +2 more sources