Results 71 to 80 of about 5,154 (256)

Acute radiation impacts contractility of guinea-pig bladder strips affecting mucosal-detrusor interactions. [PDF]

PLoS ONE, 2018
Radiation-induced bladder toxicity is associated with radiation therapy for pelvic malignancies, arising from unavoidable irradiation of neighbouring normal bladder tissue.
Bronagh M McDonnell, Paul J Buchanan, Kevin M Prise, Karen D McCloskey   +3 more
doaj   +1 more source

UDP-sugars activate P2Y 14 receptors to mediate vasoconstriction of the porcine coronary artery [PDF]

, 2018
Aims UDP-sugars can act as extracellular signalling molecules, but relatively little is known about their cardiovascular actions. The P2Y14 receptor is a Gi/o-coupled receptor which is activated by UDP-glucose and related sugar nucleotides.
Abbas, Zainab S.B., Dovlatova, Natalia, Dunn, William R., Fox, Sue C., Heptinstall, Stan, Liaque Latif, M., Ralevic, Vera   +6 more
core   +2 more sources

A Purinergic P2 Receptor Family-Mediated Increase in Thrombospondin-1 Bolsters Synaptic Density and Epileptic Seizure Activity in the Amygdala-Kindling Rat Model

Frontiers in Cellular Neuroscience, 2018
Previous studies suggested that the thrombospondin-1/transforming growth factor-β1 (TSP-1/TGF-β1) pathway might be critical in synaptogenesis during development and that the purinergic P2 receptor family could regulate synaptogenesis by modulating TSP-1 ...
Hongliu Sun, Luyu Ma, Yurong Zhang, Xiaohong Pan, Chaoyun Wang, Jinjin Zhang, Xiuli Zhang, Hongwei Sun, Qiaoyun Wang, Wei Zhu   +9 more
doaj   +1 more source

Mast Cell-Associated Serotonin in Acupoint Contributes to Acupuncture Analgesia in Arthritis Rats by Mediating ATP Release

Frontiers in Bioscience-Landmark, 2023
Background: The activation of subcutaneous mast cells (MCs) helps to trigger the analgesic effect induced by acupuncture (AP), a traditional oriental therapy, that has been gradually accepted worldwide.
Bing-Rong Li, Yu-Jia Li, Jing-Wen Xu, Meng Huang, Li-Na Wang, Di Zhang, Xue-Yong Shen, Guang-Hong Ding   +7 more
doaj   +1 more source

Pre- and postsynaptic actions of ATP on neurotransmission in rat submandibular ganglia [PDF]

, 2001
The pre- and postsynaptic actions of exogenously applied ATP were investigated in intact and dissociated parasympathetic neurotics of rat submandibular ganglia.
A.B Smith, Armour, Bo, Boehm, D.-M Liu, D.J Adams, Dutton, Edwards, Evans, Fieber, Galligan, Hamill, Hansen, Hansen, Hansen, Hansen, Inokuchi, Kawa, Khakh, Le, Li, Liu, Liu, Luetje, M.A Hansen, Nabekura, Navone, Ralevic, Seabrook, Silinsky, Smith, Smith, Sperlagh, Sun, Tenneti, von Kugelgen, Worthington, Yunaev, Zhou, Zhou   +39 more
core   +1 more source

2D-TUCKER Is PPAD-Complete [PDF]

, 2009
Tucker's lemma states that if we triangulate the unit disc centered at the origin and color the vertices with {1, ? 1,2, ? 2} in an antipodal way (if |z| = 1, then the sum of the colors of z and ? z is zero), then there must be an edge for which the sum of the colors of its endpoints is zero. But how hard is it to find such an edge? We show that if the
openaire   +2 more sources

A novel bioassay to detect Nociceptin/Orphanin FQ release from single human polymorphonuclear cells.

PLoS ONE, 2022
Nociceptin/Orphanin FQ (N/OFQ) is the endogenous opioid agonist for the N/OFQ receptor or NOP. This receptor system is involved in pain processing but also has a role in immune regulation.
M F Bird, C P Hebbes, S W M Scott, J Willets, J P Thompson, D G Lambert   +5 more
doaj   +1 more source

Pure-Circuit: Tight Inapproximability for PPAD

Journal of the ACM
The current state-of-the-art methods for showing inapproximability in PPAD arise from the ɛ-Generalized-Circuit (ɛ- GCircuit ) problem. Rubinstein (2018) showed that there exists a small unknown constant ɛ for which ɛ- GCircuit is PPAD -hard ...
Argyrios Deligkas, John Fearnley, Alexandros Hollender, Themistoklis Melissourgos   +3 more
openaire   +5 more sources

PPAD-Complete Pure Approximate Nash Equilibria in Lipschitz Games

, 2022
Lipschitz games, in which there is a limit $λ$ (the Lipschitz value of the game) on how much a player's payoffs may change when some other player deviates, were introduced about 10 years ago by Azrieli and Shmaya. They showed via the probabilistic method that $n$-player Lipschitz games with $m$ strategies per player have pure $ε$-approximate Nash ...
Paul W. Goldberg, Matthew Katzman
openaire   +2 more sources

Novel vasocontractile role of the P2Y14receptor: characterization of its signalling in porcine isolated pancreatic arteries [PDF]

, 2014
Background and Purpose: The P2Y14 receptor is the newest member of the P2Y receptor family; it is Gi/o protein-coupled and is activated by UDP and selectively by UDP-glucose and MRS2690 (2-thiouridine-5′-diphosphoglucose) (7–10-fold more potent than UDP ...
Alsaqati, M., Chan, S.L.F., Latif, M.L., Ralevic, V.   +3 more
core   +3 more sources