Results 81 to 90 of about 5,261 (261)

Dysbiosis‐Mediated Inflammation: A Pathophysiological Link Between Rheumatoid Arthritis and Periodontitis

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Aim To explore mechanistic links between rheumatoid arthritis (RA) and periodontitis (PD) through the lens of subgingival microbial dysbiosis–mediated inflammation. Methods Subgingival plaque from 100 volunteers with RA and PD (RAPD), 22 with RA (RAnoPD), 18 with PD (PDnoRA) and 19 healthy controls (noRAnoPD) was analysed using 16S‐amplicon ...
Isabel Lopez‐Oliva, Iain L. Chapple, Akshay Paropkari, Shweta Saraswat, Praveen Sharma, Stefan Serban, Paola de Pablo, Karim Raza, Andrew Filer, Thomas Dietrich, Melissa Grant, Purnima S. Kumar   +11 more
wiley   +1 more source

P2X7 receptors induce degranulation in human mast cells. [PDF]

, 2016
Mast cells play important roles in host defence against pathogens, as well as being a key effector cell in diseases with an allergic basis such as asthma and an increasing list of other chronic inflammatory conditions.
A Lundequist, A Surprenant, AG Driver, AM Gilfillan, AS Kirshenbaum, AW Hauswirth, B Hechler, C Feng, CE Owen, D Ferrari, DM Manthei, E Shigetomi, Elizabeth P. Seward, ES Schulman, F Jacob, F Virgilio Di, G Barbara, G Buell, G Burnstock, G Burnstock, H Saito, J Capite Di, JM Brown, JP Bennett, K Mulryan, K Wareham, Kathryn J. Wareham, M Idzko, M Idzko, M Vig, MA McCloskey, MG Rolf, N Sudo, OK Basoglu, PE Tatham, R Dahlquist, R Dahlquist, RC Wykes, RJ Evans, SR Holdsworth, TM Egan, Y Kurashima, Y Osipchuk, ZG Gao   +43 more
core   +1 more source

The dysregulation of innate immunity by Porphyromonas gingivalis in the etiology of Alzheimer's disease

Journal of Internal Medicine, EarlyView.
Abstract The etiology of Alzheimer's disease (AD) remains under active debate. In this perspective, we explore the hypothesis that a primarily infection‐caused chronic dysregulation and weakening of human innate immunity via the underexpression, degradation, and inactivation of innate immune proteins necessary for direct antimicrobial effects and ...
Annelise E. Barron, Jennifer S. Lin, Mark I. Ryder, Peter Bergman   +3 more
wiley   +1 more source

PPAD: Privacy Preserving Group-Based ADvertising in Online Social Networks

2018 IFIP Networking Conference (IFIP Networking) and Workshops, 2018
Services provided as free by Online Social Networks (OSN) come with privacy concerns. Users’ information kept by OSN providers are vulnerable to the risk of being sold to the advertising firms. To protect user privacy, existing proposals utilize data encryption, which prevents the providers from monetizing users’ information.
Sanaz Taheri Boshrooyeh, Alptekin Kupcu, Oznur Ozkasap   +2 more
openaire   +2 more sources

CFTR mediates noradrenaline-induced ATP efflux from DRG neurons

Molecular Pain, 2011
In our earlier study, noradrenaline (NA) stimulated ATP release from dorsal root ganglion (DRG) neurons as mediated via β3 adrenoceptors linked to Gs protein involving protein kinase A (PKA) activation, to cause allodynia. The present study was conducted
Nishizaki Tomoyuki, Kanno Takeshi
doaj   +1 more source

Cloning and characterization of a P2X receptor expressed in the central nervous system of Lymnaea stagnalis. [PDF]

PLoS ONE, 2012
P2X receptors are membrane ion channels gated by extracellular ATP. Mammals possess seven distinct P2X subtypes (P2X1-7) that have important functions in a wide array of physiological processes including roles in the central nervous system (CNS) where ...
Selvan Bavan, Volko A Straub, Tania E Webb, Steven J Ennion   +3 more
doaj   +1 more source

Photofission of heavy nuclei at energies up to 4 GeV

, 2000
Total photofission cross sections for 238U, 235U, 233U, 237Np, 232Th, and natPb have been measured simultaneously, using tagged photons in the energy range Egamma=0.17-3.84 GeV. This was the first experiment performed using the Photon Tagging Facility in
A. Longhi, A. S. Iljinov, A. S. Iljinov, B. L. Berman, C. Cetina, C. Chollet, D. I. Sober, D. I. Sober, G. Feldman, G. R. Brooks, G. Ya. Kezerashvili, Hall Crannell, J. Ahrens, J. Ahrens, J. Ahrens, J. C. Sanabria, J. C. Sanabria, J. C. Sanabria, K. Kikuchi, L. Y. Murphy, M. MacCormick, N. Bianchi, N. Bianchi, N. Bianchi, P. Heimberg, P. L. Cole, S. A. Philips, S. Michalowski, T. A. Armstrong, T. A. Armstrong, T. H. Bauer, Th. Frommhold, Th. Frommhold, V. Muccifora, W. J. Briscoe, W. Weise   +35 more
core   +2 more sources

Purinergic P2 receptors trigger adenosine release leading to adenosine A2A receptor activation and facilitation of long-term potentiation in rat hippocampal slices [PDF]

, 2003
Electrophysiological recordings were used to investigate the effects of ATP analogues on [theta]-burst-induced long-term potentiation (LTP) in rat hippocampal slices.
Almeida, T., Cunha, R. A., Mendonça, A. de, Ribeiro, J. A., Rodrigues, R. J.   +4 more
core   +1 more source

The Keystone‐Pathogen Hypothesis Updated: The Role of Porphyromonas gingivalis in Periodontitis

Journal of Periodontal Research, EarlyView.
Porphyromonas gingivalis orchestrates a coordinated manipulation of immune and inflammatory responses in periodontal tissues which leads to the generation of a dysbiotic, subgingival biofilm community, and progression of periodontitis. The type 9 secretion system, lipid A modification, and the formation of outer membrane vesicles are important ...
Mike A. Curtis, James A. Garnett, Richard P. Darveau   +2 more
wiley   +1 more source

Can PPAD Hardness be Based on Standard Cryptographic Assumptions?

Journal of Cryptology, 2017
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Rosen, Alon, Segev, Gil, Shahaf, Ido
openaire   +2 more sources