Results 21 to 30 of about 113,385 (285)

PPD in HBsAg vaccine formulation suppressed IFN-γ and IL-4 cytokine responses and induced long-lived humoral immune responses: Results from 220-day monitoring of specific IgG responses [PDF]

open access: yesIranian Journal of Basic Medical Sciences, 2022
Objective(s): HBsAg vaccine is unable to induce Th1 immune responses. Here, immune responses and long-lived IgG responses of HBsAg-Alum, HBsAg-MF59, as well as HBsAg-MF59 were compared when formulated with PPD.
Rayhaneh Mirzaee   +8 more
doaj   +1 more source

A novel ZRS variant causes preaxial polydactyly type I by increased sonic hedgehog expression in the developing limb bud. [PDF]

open access: yes, 2020
PurposePreaxial polydactyly (PPD) is a common congenital hand malformation classified into four subtypes (PPD I-IV). Variants in the zone of polarizing activity regulatory sequence (ZRS) within intron 5 of the LMBR1 gene are linked to most PPD types ...
Ahituv, Nadav   +19 more
core  

Immunotherapy of COVID-19 with Bacille Calmette – Guerin: Where is the missing red herring?

open access: yesSouthern African Journal of Infectious Diseases, 2021
Coronavirus Disease 2019 (COVID-19) morbidity and mortality was found to be less severe in countries where Bacille Calmette – Guerin (BCG) vaccination of the population is carried out.
Hari M. Saxena
doaj   +1 more source

Vertices of simple modules of symmetric groups labelled by hook partitions [PDF]

open access: yes, 2014
In this article we study the vertices of simple modules for the symmetric groups in prime characteristic $p$. In particular, we complete the classification of the vertices of simple $S_n$-modules labelled by hook ...
Danz, Susanne, Giannelli, Eugenio
core   +1 more source

On the basic mechanism of Pixelized Photon Detectors

open access: yes, 2008
A Pixelized Photon Detector (PPD) is a generic name for the semiconductor devices operated in the Geiger-mode, such as Silicon PhotoMultiplier and Multi-Pixel Photon Counter, which has high photon counting capability. While the internal mechanisms of the
Amsler   +11 more
core   +1 more source

Radiation Effects in Pinned Photodiode CMOS Image Sensors: Pixel Performance Degradation Due to Total Ionizing Dose [PDF]

open access: yes, 2012
Several Pinned Photodiode (PPD) CMOS Image Sensors (CIS) are designed, manufactured, characterized and exposed biased to ionizing radiation up to 10 kGy(SiO2 ).
Cervantes, Paola   +12 more
core   +3 more sources

Multiplex LC-MS/MS Assays for Clinical Bioanalysis of MEDI4276, an Antibody-Drug Conjugate of Tubulysin Analogue Attached via Cleavable Linker to a Biparatopic Humanized Antibody against HER-2

open access: yesAntibodies, 2019
Bioanalysis of complex biotherapeutics, such as antibody-drug conjugates (ADCs), is challenging and requires multiple assays to describe their pharmacokinetic (PK) profiles.
Morse Faria   +8 more
doaj   +1 more source

PCR-based analytics of gene therapies using adeno-associated virus vectors: Considerations for cGMP method development

open access: yesMolecular Therapy: Methods & Clinical Development, 2023
The field of gene therapy has evolved and improved so that today the treatment of thousands of genetic diseases is now possible. An integral aspect of the drug development process is generating analytical methods to be used throughout clinical and ...
Emmanuel Blay   +2 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Psychometric validation of the Worst Itch Numerical Rating Scale (WI-NRS) and other patient-reported outcome measures for assessing severity and impact of pruritus in patients with primary biliary cholangitis

open access: yesOrphanet Journal of Rare Diseases
Background Cholestatic pruritus is common in primary biliary cholangitis (PBC), often leading to sleep disturbances and substantially impairing health-related quality of life (HRQoL).
Heather Gelhorn   +9 more
doaj   +1 more source

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