Results 31 to 40 of about 54,269 (305)

Solid‐State Nanopore Characterization of Dendrimer‐Peptide Conjugates Across Defined Peptide Loadings

Advanced Materials Interfaces, EarlyView.
Solid‐state nanopores are used to interrogate dendrimer‐peptide conjugates with systematically varied peptide loading. Single‐particle ionic current signatures reveal how ligand density modulates deformability, transport pathways, and electromechanical coupling during translocation.
Chaoming Gu, Jin Woong Lee, Kamruzzaman Joty, Marisela Leon, Santosh Khatri, Janeesha Manawasinghe, Seungpyo Hong, Min Jun Kim   +7 more
wiley   +1 more source

Mycobacterial purified protein derivatives stimulate innate immunity: Malawians show enhanced tumor necrosis factor alpha, interleukin-1beta (IL-1beta), and IL-10 responses compared to those of adolescents in the United Kingdom. [PDF]

, 2004
To investigate the role of innate immunity in variable efficacy of Mycobacterium bovis BCG vaccination in Malawi and the United Kingdom, we examined 24-h tumor necrosis factor alpha, interleukin-1beta (IL-1beta), and IL-10 responses to mycobacterial ...
Elizabeth King, King, Elizabeth, Jarman, Elizabeth, Hazel M. Dockrell, Lifted Sichali, Fine, Paul E.M., Blackwell, Jenefer M., Weir, Rosemary E., Elizabeth Jarman, Sally Stenson, Nazareth, Bernadette, Warndorff, David K., Crampin, Amelia C, Black, Gillian F, Stenson, Sally, Mwaungulu, Lorren, Amelia C. Crampin, Linda Donovan, Blackwell, Jenefer M, Rosemary E. Weir, Paul E. M. Fine, Sian Floyd, Bernadette Nazareth, Fine, Paul EM, David K. Warndorff, Black, Gillian F., Crampin, Amelia C., Dockrell, Hazel M., Jenefer M. Blackwell, Floyd, Sian, Chaguluka, Steven D, Lorren Mwaungulu, Sichali, Lifted, Donovan, Linda, Steven D. Chaguluka, Warndorff, David K, Weir, Rosemary E, Chaguluka, Steven D., Dockrell, Hazel M, Ngwira, Bagrey, Bagrey Ngwira, Gillian F. Black   +41 more
core   +1 more source

Ferroelectric Devices for In‐Memory and In‐Sensor Computing

Advanced Science, EarlyView.
Inspired by biological systems, in‐memory and in‐sensor computing overcome von Neumann bottlenecks. Ferroelectric devices can mimic synaptic functions and sense stimuli like light or force, therefore are ideal for these paradigms. This review introduces the ferroelectric devices applied for in‐memory and in‐sensor computing, covering their structures ...
Hong Fang, Ronghuan Xie, Qiang Cao, Shishen Yan, Xiaolin Wang, Limei Zheng   +5 more
wiley   +1 more source

Exploring US patient and caregiver perspectives on burden associated with Friedreich Ataxia

Journal of Patient-Reported Outcomes
Background Friedreich ataxia (FA) is a hereditary degenerative disease with clinical manifestations in multiple organs characterized by progressive gait and limb ataxia.
Richard Lawson, Shobhana Natarajan, Julia R. Correll, Amy Clark, Mona L. Martin, Donald M. Bushnell, Juliana Setyawan   +6 more
doaj   +1 more source

Multiplex LC-MS/MS Assays for Clinical Bioanalysis of MEDI4276, an Antibody-Drug Conjugate of Tubulysin Analogue Attached via Cleavable Linker to a Biparatopic Humanized Antibody against HER-2

Antibodies, 2019
Bioanalysis of complex biotherapeutics, such as antibody-drug conjugates (ADCs), is challenging and requires multiple assays to describe their pharmacokinetic (PK) profiles.
Morse Faria, Marlking Peay, Brandon Lam, Eric Ma, Moucun Yuan, Michael Waldron, William R. Mylott, Meina Liang, Anton I. Rosenbaum   +8 more
doaj   +1 more source

Sustainable Synaptic Device with Two‐Dimensional Ferroelectric Materials for Neuromorphic Computing

Advanced Science, EarlyView.
α‐In2Se3 based FeSFETs can be utilized as sustainable devices through polarization switching governed by both out‐of‐plane and in‐plane polarizations. Upon reaching a fatigued state, current annealing enabled by conductance modulation can significantly enhance the endurance of FeSFETs.
Jaewook Yoo, Seokjin Oh, Minah Park, Jong Min Song, Hongseung Lee, Seohyeon Park, Sojin Jung, Seongbin Lim, Soohyun Lim, Dongsun Shin, Ji Won Heo, TaeWan Kim, Hagyoul Bae   +12 more
wiley   +1 more source

Purified Protein Derivative (PPD) Tuberculin as a Biological Response Modifier: I. Suppression of Tumor Markers by Intravenous Administration of PPD [PDF]

, 1988
1988-03Forty-two patients with neoplastic diseases received intravenous administration of PPD (PPD-V), and tumor markers were monitored between January, 1986 and February, 1987.
AOKI, HIIZU, ANDO, KOICHI, KATO, KATSUYA, NAKASHIMA, IZUMI, IINUMA, MASAO, YOSHII, SAIJI   +5 more
core   +1 more source

Uptake and Biotransformation of the Tire Rubber-derived Contaminants 6‑PPD and 6‑PPD Quinone in the Zebrafish Embryo (Danio rerio)

, 2023
N-(1,3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine (6-PPD) is a widely used antioxidant in tire rubber known to enter the aquatic environment via road runoff. The associated transformation product (TP) 6-PPD quinone (6-PPDQ) causes extreme acute toxicity
Thorsten Reemtsma, Stefan Scholz, Nico Grasse, Riccardo Massei, Bettina Seiwert (1506217), Riccardo Massei (1673176), Thorsten Reemtsma (1506211), Qiuguo Fu, Nico Grasse (16734252), Stefan Scholz (194228), Qiuguo Fu (1911511), Bettina Seiwert   +11 more
core   +2 more sources

Unraveling the Synergistic Activity‐Stability Enhancement of a High‐Entropy Perovskite Air Electrode for Dual Ceramic Electrochemical Cells

Advanced Science, EarlyView.
A high‐entropy air electrode material, Gd0.2Pr0.2Ba0.2Sr0.2Ca0.2FeO3−δ (GPBSCF), is developed for both solid oxide fuel cells and reversible protonic ceramic cells. Its enhanced activity stems from increased oxygen vacancies/holes. The stability improvement is attributed to lattice distortion, while thermal expansion reduction is synergistically due to
Ying Zhang, Yibei Wang, Zhilin Liu, Kuo Hu, Yaowen Wang, Zhen Wang, Xiyang Wang, Bingbing Niu, Wenquan Wang, Tianmin He   +9 more
wiley   +1 more source

Enhancing vaccine clinical trials participation among elderly: challenges and strategies

Trials
As the fastest growing demographic worldwide, the elderly population is projected to reach nearly 1 billion by 2030 and double the 2022 number by 2050.
Paul Gillard, Samer Nakhle, Darin Brimhall, Ouzama Henry, Narcisa Mesaros   +4 more
doaj   +1 more source