Results 181 to 190 of about 14,528 (201)
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Anomalous synthesis of ppGpp in growing cells
Cell, 1977In E. coli cells, accumulation of ppGpp is normally triggered by conditions that restrict the aminoacylation of tRNA or interfere with carbon/energy source metabolism; in both cases, the nucleotide's accumulation is associated with control of stable RNA synthesis and is generally believed to bring it about.
J, Gallant, L, Palmer, C C, Pao
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Synthesis of ppGpp by mouse embryonic ribosomes
Cell, 1974Abstract The unusual nucleotide guanosine tetraphosphate (ppGpp) is synthesized in vitro by ribosomes isolated from mouse embryos, but is not formed by ribosomes isolated from adults. Analysis of specific organs shows a developmental change in detectable ppGpp-forming ability.
J D, Irr, M S, Kaulenas, B R, Unsworth
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ppGpp-Dependent leuO Expression in Bacteria under Stress
Biochemical and Biophysical Research Communications, 2000Despite the known potential transcription regulatory role of leuO gene product, LeuO, the condition when leuO expresses during bacterial growth cycle remains unclear. Mechanistically, leuO expression was shown to be part of promoter relay mechanism, however, the factor(s) responsible for the regulation of leuO expression is not known.
M, Fang, A, Majumder, K J, Tsai, H Y, Wu
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The magic dance of the alarmones (p)ppGpp
Molecular Microbiology, 2016SummaryThe alarmones (p)ppGpp are important second messengers that orchestrate pleiotropic adaptations of bacteria and plant chloroplasts in response to starvation and stress. Here, we review our structural and mechanistic knowledge on (p)ppGpp metabolism including their synthesis, degradation and interconversion by a highly diverse set of enzymes ...
Wieland, Steinchen, Gert, Bange
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Translational accuracy enhanced in vitro by (p)ppGpp
Molecular and General Genetics MGG, 1980The effect of (p)ppGpp on the accuracy of translation in vitro was studied with a system that has a missense error frequency similar to that of living bacteria. When poly (U) is translated, limitation of the system in Phe increases the Leu missense error frequency.
E G, Wagner, C G, Kurland
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Revisiting the stringent response, ppGpp and starvation signaling
Current Opinion in Microbiology, 2001Microbial adaptation to environmental stress plays an important role in survival. It is necessary to understand the mechanisms underlying the survival of microbes under stress, as they may eventually aid in the successful control of the growth and persistence of these organisms.
Chatterji, Dipankar, Ojha, Anil Kumar
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1980
Faced with a shortage of nutrient source, bacteria rapidly adjust their metabolism and adapt to a more frugal life style. Of the doubtless many overlapping and hierarchical controls required for such an adjustment, a simple mechanism mediated by the peculiar nucleotide guanosine 5′-diphosphate,3′-diphosphate (ppGpp) will be reviewed and its metabolism ...
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Faced with a shortage of nutrient source, bacteria rapidly adjust their metabolism and adapt to a more frugal life style. Of the doubtless many overlapping and hierarchical controls required for such an adjustment, a simple mechanism mediated by the peculiar nucleotide guanosine 5′-diphosphate,3′-diphosphate (ppGpp) will be reviewed and its metabolism ...
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Kinetic suppression of translational errors by (p)ppGpp
Molecular and General Genetics MGG, 1982The effect of (p)ppGpp on the accuracy of translation was studied in vitro using a poly(U)-programmed poly(Phe)-synthesizing system operating at incorporation rates and missense error frequencies close to the values obtained in vivo. Simulation of a relaxed phenotype in vitro was accomplished by limitation of the cognate aminoacyl-tRNA synthetase ...
E. Gerhart +3 more
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ppGpp inhibits the activity of Escherichia coli DnaG primase
Plasmid, 2010DNA primase is an enzyme required for replication of both chromosomes and vast majority of plasmids. Guanosine tetra- and penta-phosphate (ppGpp and pppGpp, respectively) are alarmones of the bacterial stringent response to starvation and stress conditions, and act by modulation of the RNA polymerase activity.
Monika, Maciag +4 more
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ppGpp: stringent response and survival.
Journal of microbiology (Seoul, Korea), 2006Adaptation to any undesirable change in the environment dictates the survivability of many microorganisms, with such changes generating a quick and suitable response, which guides the physiology of bacteria. During nutritional deprivation, bacteria show a stringent response, as characterized by the accumulation of (p)ppGpp, resulting in the repression ...
Jain, Vikas +2 more
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