Results 21 to 30 of about 148,011 (215)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Towards Entrepreneurial Campus Sustainability: Integrating Artificial Intelligence for Resource Allocation in Business Management

Aptisi Transactions on Technopreneurship
This research delves into the utilization of artificial intelligence (AI) within the framework of campus resource allocation, with a primary focus on enhancing business management practices and fostering entrepreneurial sustainability within educational ...
Juanda Juanda, Reza Juang Riansyah, Arsadi Arsadi, Laurens Bethany   +3 more
doaj   +1 more source

Proton pump inhibitors overuse - consequences among patients

Journal of Education, Health and Sport, 2019
Introduction Omeprazole was first proton pump inhibitor (PPI) approved for use by patients. Thirty years have passed since then. Due to their effectiveness, low price and safety proton pump inhibitors have become one of the most frequently prescribed ...
Patrycja Kmiotek, Andrzej Materniak, Barbara Skrzydło-Radomańska   +2 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Association Between Proton Pump Inhibitor Use and Extended-Spectrum Beta-Lactamase Urinary Tract Infection in Adults: A Retrospective Study

Infection and Drug Resistance, 2023
Nishan Kunnummal Purayil,1– 3 Vamanjore A Naushad,1– 3 Prem Chandra,4 Prakash Joseph,1,2 Zahida Khalil,1,2 Muhammad Zahid,1,3 Godwin Wilson,3,5 Muhammed Kunhi Kayakkool,1– 3 Basma Ayari,1,3 Sajid Chalihadan,1 Emad Bashier I Elmagboul,5 Sanjay H Doiphode3,
Purayil NK, Naushad VA, Chandra P, Joseph P, Khalil Z, Zahid M, Wilson G, Kayakkool MK, Ayari B, Chalihadan S, Elmagboul EBI, Doiphode SH   +11 more
doaj  

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Patient and public involvement in the design of an international clinical trial: real world experience

Research Involvement and Engagement
Background The value of patient and public involvement (PPI) during the earliest stages of clinical trial development, and prior to the award of substantive funding, is widely recognised. However, it is often under-resourced and PPI processes during this
Gwenda Simons, Helen Jones, Ian Clarke, Firoza Davies, Stacey Grealis, Elspeth Insch, Hameed Kahn, Joanne Lloyd, Al Richards, Hayley Rose, Ruth Williams, Maarten de Wit, Clarissa Woodcock, Leigh Romaniuk, Michelle Bardgett, Arthur G. Pratt, Marie Falahee   +16 more
doaj   +1 more source

Proton Pump Inhibitor Therapy for Eosinophilic Esophagitis: History, Mechanisms, Efficacy, and Future Directions

Journal of Asthma and Allergy, 2022
James P Franciosi,1,2 Edward B Mougey,3 Evan S Dellon,4 Carolina Gutierrez-Junquera,5 Sonia Fernandez-Fernandez,6 Rajitha D Venkatesh,7 Sandeep K Gupta8 1Division of Gastroenterology, Nemours Children’s Hospital, Orlando, FL, USA; 2College of Medicine ...
Franciosi JP, Mougey EB, Dellon ES, Gutierrez-Junquera C, Fernandez-Fernandez S, Venkatesh RD, Gupta SK   +6 more
doaj  

Possibilities for prescribing lansoprazole in the outpatient practice

Медицинский совет, 2019
Acid-dependent diseases are an urgent problem of modern gastroenterology. Antisecretory agents are first-line drugs in the treatment of this pathology, the leaders among which are proton pump inhibitors (PPI). Due to the wide representation of this group
I. G. Pakhomova, E. Yu. Pavlova
doaj   +1 more source