Results 41 to 50 of about 350,201 (281)

Reconstruction of Network Evolutionary History from Extant Network Topology and Duplication History

, 2012
Genome-wide protein-protein interaction (PPI) data are readily available thanks to recent breakthroughs in biotechnology. However, PPI networks of extant organisms are only snapshots of the network evolution.
A. Barabasi, A. Bhan, A. Vazquez, A. Wagner, I. Ispolatov, J. Bar-Ilan, J. Dutkowski, J. Pinney, L. Hakes, M. Middendorf, M. Stumpf, N. Farid, R. Pastor-Satorras, R. Patro, R. Sole, S. Navlakha, T. Yamada   +16 more
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Highlights of the 2013 PPI User Survey [PDF]

, 2013
From December 2012 to May 2013, the Bureau of Labor Statistics (BLS) Producer Price Index (PPI) program conducted a user survey of its stakeholders in order to learn more about the program’s data users and how they utilize PPI data.
Kelley, Joseph, Lombardozzi, Antonio
core   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Patient and public involvement in the design of an international clinical trial: real world experience

Research Involvement and Engagement
Background The value of patient and public involvement (PPI) during the earliest stages of clinical trial development, and prior to the award of substantive funding, is widely recognised. However, it is often under-resourced and PPI processes during this
Gwenda Simons, Helen Jones, Ian Clarke, Firoza Davies, Stacey Grealis, Elspeth Insch, Hameed Kahn, Joanne Lloyd, Al Richards, Hayley Rose, Ruth Williams, Maarten de Wit, Clarissa Woodcock, Leigh Romaniuk, Michelle Bardgett, Arthur G. Pratt, Marie Falahee   +16 more
doaj   +1 more source

Association Between Proton Pump Inhibitor Use and Extended-Spectrum Beta-Lactamase Urinary Tract Infection in Adults: A Retrospective Study

Infection and Drug Resistance, 2023
Nishan Kunnummal Purayil,1– 3 Vamanjore A Naushad,1– 3 Prem Chandra,4 Prakash Joseph,1,2 Zahida Khalil,1,2 Muhammad Zahid,1,3 Godwin Wilson,3,5 Muhammed Kunhi Kayakkool,1– 3 Basma Ayari,1,3 Sajid Chalihadan,1 Emad Bashier I Elmagboul,5 Sanjay H Doiphode3,
Purayil NK, Naushad VA, Chandra P, Joseph P, Khalil Z, Zahid M, Wilson G, Kayakkool MK, Ayari B, Chalihadan S, Elmagboul EBI, Doiphode SH   +11 more
doaj  

Uncertainty of net present value calculations and the impact on applying integrated maintenance approaches to the UK rail industry [PDF]

, 2015
The Public performance indicator (PPI) is an important Key Performance Indicator for Network Rail and monitored carefully by the organisation and their external stakeholders.
Andrew, Starr, Baguley, Paul, Kirkwood, Leigh, Shehab, Essam   +3 more
core   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Proton Pump Inhibitor Therapy for Eosinophilic Esophagitis: History, Mechanisms, Efficacy, and Future Directions

Journal of Asthma and Allergy, 2022
James P Franciosi,1,2 Edward B Mougey,3 Evan S Dellon,4 Carolina Gutierrez-Junquera,5 Sonia Fernandez-Fernandez,6 Rajitha D Venkatesh,7 Sandeep K Gupta8 1Division of Gastroenterology, Nemours Children’s Hospital, Orlando, FL, USA; 2College of Medicine ...
Franciosi JP, Mougey EB, Dellon ES, Gutierrez-Junquera C, Fernandez-Fernandez S, Venkatesh RD, Gupta SK   +6 more
doaj  

Possibilities for prescribing lansoprazole in the outpatient practice

Медицинский совет, 2019
Acid-dependent diseases are an urgent problem of modern gastroenterology. Antisecretory agents are first-line drugs in the treatment of this pathology, the leaders among which are proton pump inhibitors (PPI). Due to the wide representation of this group
I. G. Pakhomova, E. Yu. Pavlova
doaj   +1 more source