Results 61 to 70 of about 148,011 (215)

Dual‐Organelle Secretome Conjugation and Organ‐Uptake Tracking (DuO‐SCOUT) Enables Deep and Sensitive Mapping of the Secreted Proteins

Advanced Science, EarlyView.
A novel dual‐organelle proximity labeling platform, DuO‐SCOUT, decodes the complex landscape of systemic organ‐organ communication by capturing both classical and unconventional secretomes. Application in metabolic models maps the adipose‐to‐brain secretory relay, identifying selective extra‐hypothalamic sites for adipose‐derived factors and expanding ...
Fenglian Yang, Rui Qian, Jiaxing Song, Xingqi Meng, Jin Young Kim, Kwok On Lai, Li Wang, Liang Zhang   +7 more
wiley   +1 more source

Intelligence and psychopathy: A study on non-incarcerated females from the normal population

Cogent Psychology, 2018
Most research on the relation between psychopathy and intelligence has been conducted with incarcerated male samples. However, psychopathic traits can be found among non-incarcerated individuals, male or female, possessing high intellectual capacities ...
Tal Ben-Yaacov, Joseph Glicksohn
doaj   +1 more source

Photobiomodulation‑Engineered Extracellular Vesicles Enhance Neural Differentiation via UFL1‑Mediated UFMylation in Spinal Cord Injury

Advanced Science, EarlyView.
Photobiomodulated microglia release engineered extracellular vesicles that deliver UFL1 to the injured spinal cord. UFL1 competitively binds p53 with MDM2, inhibiting p53 ubiquitination and stabilizing p53 signaling. This dual mechanism simultaneously promotes anti‐inflammatory microglial polarization and directs neural stem cell differentiation toward
Yunxiao Fang, Zuomeng Wu, Ruocheng Guo, Cancan Wang, Yue Qin, Yixiang Dong, Aoyun Li, Ao Liu, Chongyu Jia, Tianyu Han, Peiwen Song, Lei Chen, Cailiang Shen   +12 more
wiley   +1 more source

Buenas prácticas en la enseñanza del inglés como lengua extranjera: estudiantes de Práctica Profesional I - UPNFM - Honduras

Revista Digital de Políticas Lingüísticas, 2021
La práctica profesional es un espacio formativo en la que los futuros docentes del sistema educativo hondureño muestran las competencias adquiridas durante los años de formación teórica en las aulas de la Universidad Pedagógica Nacional Francisco Morazán
Clara Elizabeth Chávez Suazo
doaj  

Las pinturas zoomorfas punteadas del Paleolítico Superior cantábrico: hacia una cronología dilatada de una tradición gráfica homogénea

Trabajos de Prehistoria, 2008
Las cuevas decoradas con animales punteados rojos son una de las principales expresiones pictóricas propias del Paleolítico Superior cantábrico. Los nuevos descubrimientos así como la introducción de sistemas novedosos de datación han abierto la ...
Diego Gárate Maidagan
doaj   +1 more source

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

Randomised controlled trial of silk therapeutic garments for the management of atopic eczema in children: the CLOTHES trial

Health Technology Assessment, 2017
Background: Atopic eczema (AE) is a chronic, itchy, inflammatory skin condition that affects the quality of life of children and their families. The role of specialist clothing in the management of AE is poorly understood.
Kim S Thomas, Lucy E Bradshaw, Tracey H Sach, Fiona Cowdell, Jonathan M Batchelor, Sandra Lawton, Eleanor F Harrison, Rachel H Haines, Amina Ahmed, Taraneh Dean, Nigel P Burrows, Ian Pollock, Hannah K Buckley, Hywel C Williams, Joanne Llewellyn, Clare Crang, Jane D Grundy, Juliet Guiness, Andrew Gribbin, Eileen V Wake, Eleanor J Mitchell, Sara J Brown, Alan A Montgomery   +22 more
doaj   +1 more source

Emoção, atividade e criatividade – possíveis aproximações - doi: 10.4025/imagenseduc.v2i1.14549

Imagens da Educação, 2012
Este texto pretende apresentar uma reflexão sobre a atividade humana, com base na teoria de Leontiev (1983), como processo essencial para a apreensão da realidade objetiva e, consequentemente, seu papel fundamental na determinação das funções psíquicas ...
Rafael Egidio Leal e Silva, Renata da Silva, Silvana Calvo Tuleski   +2 more
doaj   +1 more source

Inorganic Nanomaterials can Promote or Inhibit Tumor Metastasis Depending on Tumor Microenvironment Composition

Advanced Science, EarlyView.
As engineered nanomaterials gain prominence in cancer imaging and therapy, understanding their impact on tumor progression becomes increasingly critical. We demonstrate that gold and silica‐coated gold nanomaterials can either suppress or enhance breast cancer metastasis through distinct tumor microenvironment interactions, while identifying ...
Kiana Buttiens, Xiaoqi Zheng, Xueqi Fan, Mukaddes Izci, Christy Maksoudian, Irati Perez Gilabert, Tianjiao Chu, Filipa Goncalves, Jonas Dehairs, Johan Swinnen, Bella B. Manshian, Stefaan J. Soenen   +11 more
wiley   +1 more source

In silico prediction of differentially expressed genes and functionally grouped networks in patients with inflamed pulp for screening pulpitis biomarkers

European Oral Research
Purpose: Pulpitis is one of the most common oral inflammatory diseases. There are many limitations in the traditional methods of diagnosing pulpitis. By replacing new diagnostic ways based on biomarkers, it is possible to quickly and accurately identify ...
Azizeh Asadzadeh, Fatemeh Shams Moattar, Azam Moshfegh   +2 more
doaj   +1 more source