Results 91 to 100 of about 7,127 (231)
The Concise Guide to PHARMACOLOGY 2025/26: Enzymes
British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +31 more
wiley +1 more source
tRNA 3\u27-amino-tailing for stable amino acid attachment. [PDF]
, 2018 Amino acids are attached to the tRNA 3\u27-end as a prerequisite for entering the ribosome for protein synthesis. Amino acid attachment also gives tRNA access to nonribosomal cellular activities.
Gamper, Howard, Hou, Ya-Ming
core +1 more source
Citrullination in Tumor Metastasis, Inside and Outside the Cells
Cancer Science, Volume 116, Issue 12, Page 3239-3249, December 2025.ABSTRACT Tumor metastasis remains a poor prognosis because it occurs in all tissues and is difficult to diagnose or prevent before metastatic tumor nodules form. Metastasis is a multi‐step process involving tumor cells, bone marrow‐derived cells, and tissue resident cells, making it a biological three‐body problem.
Takeshi Tomita +2 more
wiley +1 more source
Scientific Reports, 2019 Pin1, a polypeptide proline isomerase parvulin, plays a key role in Alzheimer’s disease (AD), common tumors and cancers. Two conservative histidine residues, His59 and His157, are important for maintaining the stability of the PPIase domain.
Wang Wang +6 more
doaj +1 more source
Molecules, 2017 Allosteric communication among domains in modular proteins consisting of flexibly linked domains with complimentary roles remains poorly understood. To understand how complementary domains communicate, we have studied human Pin1, a representative modular
Jing Wang +5 more
doaj +1 more source
British Journal of Pharmacology, Volume 182, Issue 22, Page 5647-5669, November 2025.Background and Purpose Chronic liver disease and hepatic fibrosis constitute a threat to global health. Clinical translation of preclinical research has been limited, highlighting an urgent need for novel treatments. Cyclophilin inhibitors have shown beneficial effects in liver disease; however, the underlying mechanism of action and the effect across ...
Una Rastovic +24 more
wiley +1 more source
Solution structural analysis of the single-domain parvulin TbPin1. [PDF]
PLoS ONE, 2012 Pin1-type parvulins are phosphorylation-dependent peptidyl-prolyl cis-trans isomerases. Their functions have been widely reported to be involved in a variety of cellular responses or processes, such as cell division, transcription, and apoptosis, as well
Lifang Sun +6 more
doaj +1 more source
Molecular Cochaperones: Tumor Growth and Cancer Treatment [PDF]
, 2014 Molecular chaperones play important roles in all cellular organisms by maintaining the proteome in an optimally folded state. They appear to be at a premium in cancer cells whose evolution along the malignant pathways requires the fostering of cohorts of
Calderwood, Stuart K.
core +1 more source
Peptidylprolyl Isomerases as In Vivo Carriers for Drugs That Target Various Intracellular Entities
Biomolecules, 2017 Analyses of sequences and structures of the cyclosporine A (CsA)-binding proteins (cyclophilins) and the immunosuppressive macrolide FK506-binding proteins (FKBPs) have revealed that they exhibit peculiar spatial distributions of charges, their overall ...
Andrzej Galat
doaj +1 more source
ZMYND10 functions in a chaperone relay during axonemal dynein assembly [PDF]
, 2018 Molecular chaperones promote the folding and macromolecular assembly of a diverse set of ‘client’ proteins. How ubiquitous chaperone machineries direct their activities towards specific sets of substrates is unclear.
Dodd Daniel O +17 more
core +8 more sources