Results 71 to 80 of about 3,214 (169)
Peptidylprolyl Isomerases as In Vivo Carriers for Drugs That Target Various Intracellular Entities
Biomolecules, 2017 Analyses of sequences and structures of the cyclosporine A (CsA)-binding proteins (cyclophilins) and the immunosuppressive macrolide FK506-binding proteins (FKBPs) have revealed that they exhibit peculiar spatial distributions of charges, their overall ...
Andrzej Galat
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Advanced Science, Volume 13, Issue 4, 19 January 2026.Summary diagram for the role of CypA in chemoresistance in non‐small cell lung cancer (NSCLC). CypA is overexpressed in chemoresistance NSCLC and drives therapeutic evasion by competitively binding to the K37 site of SLC7A11, thereby blocking TRIM3 mediated K11‐linked ubiquitination and proteasomal degradation, ultimately inhibiting lipid peroxidation ...
Zhongcheng Wang +9 more
wiley +1 more source
Food Science &Nutrition, Volume 14, Issue 1, January 2026.This study explored malate‐accumulation mechanisms in “Hujingmilu” peaches under different storage conditions. Low temperature (LT) delayed firmness decline and maintained higher malate. Transcriptomics showed malate biosynthetic genes weakly correlate with malate levels, while proton pump and transporter genes were up‐regulated under LT.
Hongfang Cai +6 more
wiley +1 more source
Protein Science, Volume 34, Issue 12, December 2025.Abstract Ion channel activity is intricately linked to the surrounding lipid environment, yet the molecular effects of lipid‐mediated regulation remain largely understudied. Here, we show that membrane‐forming phospholipids, which are known to modulate the activity of the cyclic nucleotide‐gated channel SthK from Spirochaeta thermophila, exhibit ...
Ashley J. Newton +3 more
wiley +1 more source
A Family of Novel Cyclophilins, Conserved in the Mimivirus Genus of the Giant DNA Viruses
Computational and Structural Biotechnology Journal, 2018 The cyclophilin (abbreviated here as CYN) family represents a large group of protein prolyl isomerase (PPIase), many of which are also chaperones that promote proper folding of a large variety of client proteins. Over the past few years, megaviruses with
Sailen Barik
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Small Methods, Volume 9, Issue 12, December 1, 2025.A novel approach is developed to pancreatic cancer screening by targeting the cyclophili‐B (CypB)protein using a molecularly imprinted polymer with the electrode material containing Pt single‐atom‐doped/SeS2‐Ti3CNTx MXene. The quantification of CypB in pancreatic cancer tissues provide an insight into the association of CypB with pancreatic cancer ...
Sathish Panneer Selvam +3 more
wiley +1 more source
Journal of medicinal chemistry, 2016 Peptidyl-proline isomerases (PPIases) are a chaperone superfamily comprising the FK506-binding proteins (FKBPs), cyclophilins, and parvulins. PPIases catalyze the cis/trans isomerization of proline, acting as a regulatory switch during folding, activation, and/or degradation of many proteins.
Dunyak, Bryan M, Gestwicki, Jason E
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The Multiple Roles of Peptidyl Prolyl Isomerases in Brain Cancer
Biomolecules, 2018 Peptidyl prolyl isomerases (PPIases) are broadly expressed enzymes that accelerate the cis-trans isomerization of proline peptide bonds. The most extensively studied PPIase family member is protein interacting with never in mitosis A1 (PIN1), which ...
Stefano Stifani
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The Concise Guide to PHARMACOLOGY 2025/26: Enzymes
British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +31 more
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Human cyclophilin 40 unravels neurotoxic amyloids.
PLoS Biology, 2017 The accumulation of amyloidogenic proteins is a pathological hallmark of neurodegenerative disorders. The aberrant accumulation of the microtubule associating protein tau (MAPT, tau) into toxic oligomers and amyloid deposits is a primary pathology in ...
Jeremy D Baker +18 more
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