Results 51 to 60 of about 3,214 (169)

PPIase independent chaperone‐like function of recombinant human Cyclophilin A during arginine kinase refolding [PDF]

FEBS Letters, 2013
Whether Cyclophilin A (CyPA) functions as a foldase or a chaperone when assisting protein folding has long been argued. In this study, we engineered four variants of recombinant human Cyclophilin A (rhCyPA), all of which were inactive to tetrapeptide substrate Suc‐AAPF‐pNA.
Zhang, Xin-Chao, Wang, Wei-Dong, Wang, Jin-Song, Pan, Ji-Cheng   +3 more
openaire   +2 more sources

Light‐Activated Protein‐Imprinted Hydrogels Capable of Translating Protein Surface Accessibility Into Missing‐Peptide Footprints

Small Structures, Volume 7, Issue 6, June 2026.
Light‐activated protein‐imprinted PFPA‐functionalized hydrogels crosslink captured proteins and report protein surface accessibility as missing‐peptide patterns readable by standard LC‐MS/MS. Mass spectrometry (MS)‐based structural proteomics can reveal higher‐order structural features in complex biological samples, but many covalent footprinting and ...
Eisuke Kanao, Taichi Nihei, Kankichi Kako, Asato Maeda, Damla Ulker, Hiroshi Nishida, Kosuke Ogata, Mingdi Yan, Sergey Piletsky, Yasushi Ishihama, Takuya Kubo   +10 more
wiley   +1 more source

Crystal Structure of the PP2A Phosphatase Activator: Implications for Its PP2A-Specific PPIase Activity [PDF]

Molecular Cell, 2006
PTPA, an essential and specific activator of protein phosphatase 2A (PP2A), functions as a peptidyl prolyl isomerase (PPIase). We present here the crystal structures of human PTPA and of the two yeast orthologs (Ypa1 and Ypa2), revealing an all alpha-helical protein fold that is radically different from other PPIases.
Leulliot, Nicolas, Vicentini, Giorgia, Jordens, Jan, Quevillon-Cheruel, Sophie, Schiltz, Marc, Barford, David, Van Tilbeurgh, Herman, Goris, Jozef   +7 more
openaire   +2 more sources

Engineering Streptococcus thermophilus for heterologous gene expression of cell envelope proteases from lactic acid bacteria

Microbial Cell Factories
Background Cell envelope proteinases have long played a pivotal role in dairy science. However, as demand for alternative food sources grows, their application in plant-based food matrices is scarcely investigated.
Joanna Ivy Irorita Fugaban, Emilie Munk, Saria Otani, Pascal Fourcassié, Claus Heiner Bang-Berthelsen, Egon Bech Hansen   +5 more
doaj   +1 more source

The FKBP52 Cochaperone Acts in Synergy with β-Catenin to Potentiate Androgen Receptor Signaling. [PDF]

PLoS ONE, 2015
FKBP52 and β-catenin have emerged in recent years as attractive targets for prostate cancer treatment. β-catenin interacts directly with the androgen receptor (AR) and has been characterized as a co-activator of AR-mediated transcription.
Cheryl Storer Samaniego, Ji Ho Suh, Arundhati Chattopadhyay, Karen Olivares, Naihsuan Guy, Jeffrey C Sivils, Prasenjit Dey, Fumiaki Yumoto, Robert J Fletterick, Anders M Strom, Jan-Åke Gustafsson, Paul Webb, Marc B Cox   +12 more
doaj   +1 more source

TAL effectors target the C-terminal domain of RNA polymerase II (CTD) by inhibiting the prolyl-isomerase activity of a CTD-associated cyclophilin. [PDF]

PLoS ONE, 2012
Transcriptional activator-like (TAL) effectors of plant pathogenic bacteria function as transcription factors in plant cells. However, how TAL effectors control transcription in the host is presently unknown.
Mariane Noronha Domingues, Bruna Medeia de Campos, Maria Luiza Peixoto de Oliveira, Uli Quirino de Mello, Celso Eduardo Benedetti   +4 more
doaj   +1 more source

The GmGT‐2F, a trihelix transcription factor, regulates seed oil content by directly activating GmAGAL transcription in soybean

Journal of Integrative Plant Biology, Volume 68, Issue 6, Page 1794-1814, June 2026.
In soybean, the trihelix transcription factor GmGT‐2F positively regulates the expression of the α‐galactosidase gene GmAGAL, thereby modulating seed oil content. The cyclophilin GmCYP2 interacts with GmGT‐2F and suppresses GmAGAL activation. Haplotype diversity analysis of GmGT‐2F, GmCYP2, and GmAGAL identified favorable haplotype combinations ...
Shuangzhe Li, Yifan Cui, Yang Liu, Mingliang Yang, Xiaoxia Wu, Qingshan Chen, Ying Zhao   +6 more
wiley   +1 more source

Molecular Evolution of the Vertebrate FK506 Binding Protein 25

International Journal of Genomics, 2014
FK506 binding proteins (FKBPs) belong to immunophilins with peptidyl-prolyl isomerases (PPIases) activity. FKBP25 (also known as FKBP3) is one of the nuclear DNA-binding proteins in the FKBPs family, which plays an important role in regulating ...
Fei Liu, Xiao-Long Wei, Hao Li, Ji-Fu Wei, Yong-Qing Wang, Xiao-Jian Gong   +5 more
doaj   +1 more source

Requirement of a mip-Like Gene for Virulence in the Phytopathogenic Bacterium Xanthomonas campestris pv. campestris

Molecular Plant-Microbe Interactions, 2007
Macrophage infectivity potentiators (Mips) are FKBP domain-containing proteins reported as virulence factors in several human pathogens, such as members of genera Legionella, Salmonella and Chlamydia.
Ning Zang, Dong-Jie Tang, Mei-Liang Wei, Yong-Qiang He, Baoshan Chen, Jia-Xun Feng, Jing Xu, Yong-Qi Gan, Bo-Le Jiang, Ji-Liang Tang   +9 more
doaj   +1 more source

Deciphering photosynthetic protein networks: a crosslinking‐MS strategy for studying functional thylakoid membranes

The Plant Journal, Volume 126, Issue 5, June 2026.
SUMMARY Photosynthesis, which sustains life on Earth, depends on organized and yet adaptable protein assemblies embedded in specialized membranes known as thylakoids. Understanding how these complexes interact and reorganize within functional photosynthetic membranes is essential to reveal the molecular basis of energy conversion in cells.
Nicolas Frances, Cecile Giustini, Giovanni Finazzi, Myriam Ferro, Pascal Albanese   +4 more
wiley   +1 more source