Results 41 to 50 of about 3,214 (169)

NMR assignments of the FKBP-type PPIase domain of FKBP42 from Arabidopsis thaliana [PDF]

open access: yesBiomolecular NMR Assignments, 2011
The Atfkbp42 gene is associated with reduced and disoriented growth of Arabidopsis thaliana. Resonance assignments are reported for the FKBP-type PPIase domain of AtFKBP42. Signal intensities reveal an additional structure element that is atypical for such FKBP domains.
Burgardt Noelia Inés   +4 more
openaire   +4 more sources

PrsA2 (CD630_35000) of Clostridioides difficile Is an Active Parvulin-Type PPIase and a Virulence Modulator

open access: yesFrontiers in Microbiology, 2018
Clostridioides difficile is the main cause for nosocomial antibiotic associated diarrhea and has become a major burden for the health care systems of industrial countries.
Can Murat Ünal   +11 more
doaj   +1 more source

Unfolding Plant Defence: Endoplasmic Reticulum Stress Signalling at the Plant‐Pathogen Interface

open access: yesPlant Biotechnology Journal, Volume 24, Issue 8, Page 4799-4822, August 2026.
ABSTRACT The endoplasmic reticulum (ER) stress response, a conserved proteostasis network, has emerged as a central hub that reprograms plant immunity during pathogen attack. This review synthesises how plants harness ER‐stress signalling to mount multilayered defences and how pathogens have evolved counterstrategies to subvert these pathways.
Zhe Meng   +8 more
wiley   +1 more source

Molecular docking analysis of juglone with parvulin-type PPiase PrsA from Staphylococcus aureus

open access: yesBioinformation, 2023
Staphylococcus aureus is an opportunistic pathogen that causes variety of infections range from mild skin diseases to life-threatening sepsis. It is also notorious for acquiring resistance to numerous antibiotics. Parvulin-type peptidyl-prolyl cis-trans isomerase (PPiase) domain containing PrsA protein is considered as an essential folding factor for ...
Dipten, Laskar   +2 more
openaire   +2 more sources

Components of SurA required for outer membrane biogenesis in uropathogenic Escherichia coli.

open access: yesPLoS ONE, 2008
BackgroundSurA is a periplasmic peptidyl-prolyl isomerase (PPIase) and chaperone of Escherichia coli and other Gram-negative bacteria. In contrast to other PPIases, SurA appears to have a distinct role in chaperoning newly synthesized porins destined for
Kristin M Watts, David A Hunstad
doaj   +1 more source

Abnormal type I collagen post-translational modification and crosslinking in a cyclophilin B KO mouse model of recessive osteogenesis imperfecta. [PDF]

open access: yesPLoS Genetics, 2014
Cyclophilin B (CyPB), encoded by PPIB, is an ER-resident peptidyl-prolyl cis-trans isomerase (PPIase) that functions independently and as a component of the collagen prolyl 3-hydroxylation complex.
Wayne A Cabral   +14 more
doaj   +1 more source

Elucidation of DNA Primase as a Drug Target in Leishmania donovani: Structure‐Guided Inhibitor Identification and Biochemical Validation

open access: yesChemical Biology &Drug Design, Volume 108, Issue 1, July 2026.
Structure‐guided and biochemical analyses indicate that DNA primase of Leishmania donovani represents a potential therapeutic target, as repurposed compounds, particularly Pritelivir, demonstrate marked inhibitory effects accompanied by reduced parasite proliferation, replication, and altered cellular morphology in in vitro and cell‐based studies ...
Deep Bhowmik   +3 more
wiley   +1 more source

Biochemical and functional characterization of Brucella abortus cyclophilins: So similar, yet so different

open access: yesFrontiers in Microbiology, 2022
Brucella spp. are the etiological agent of animal and human brucellosis. We have reported previously that cyclophilins of Brucella (CypA and CypB) are upregulated within the intraphagosomal replicative niche and required for stress adaptation and host ...
Emanuel J. Muruaga   +5 more
doaj   +1 more source

The Moniliophthora roreri Effector MrB1 Affects Cellular Homeostasis and Induces Genotype‐Dependent Necrosis in Theobroma cacao

open access: yesMolecular Plant Pathology, Volume 27, Issue 7, July 2026.
The effector MrB1 induces cytotoxicity in plant cells through oxidative stress, membrane damage, protein folding collapse, and energy failure. These alterations compromise cellular integrity and result in necrosis. ABSTRACT Frosty pod rot (FPR) is an invasive disease responsible for severe yield losses of cacao trees.
Taís Araújo Santos   +7 more
wiley   +1 more source

Genomic and Transcriptomic Insights Into Salinity Tolerance in Dry Pea

open access: yesLegume Science, Volume 8, Issue 2, June 2026.
ABSTRACT Salinity is a major crop production constraint in dry pea (Pisum sativum L.), making the development of salt‐tolerant varieties essential to improve crop productivity and land‐use efficiency. The genetic mechanisms of salt tolerance in dry pea are largely unknown, and research on salt‐tolerant genes is limited.
Shailesh Raj Acharya   +11 more
wiley   +1 more source

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