Results 31 to 40 of about 3,959 (198)

Genome-wide characterization of peptidyl-prolyl  cis–trans  isomerases in Penicillium and their regulation by salt stress in a halotolerant P. oxalicum

Scientific Reports, 2021
Peptidyl-prolyl cis–trans isomerases (PPIases) are the only class of enzymes capable of cis–trans isomerization of the prolyl peptide bond. The PPIases, comprising of different families viz., cyclophilins, FK506-binding proteins (FKBPs), parvulins and ...
Mangaljeet Singh, Kirandeep Kaur, Avinash Sharma, Rajvir Kaur, Dimple Joshi, Megha Chatterjee, Iman Dandapath, Amarjeet Kaur, Harpreet Singh, Prabhjeet Singh   +9 more
doaj   +1 more source

Molecular and Biochemical Characterization of the Parvulin-Type PPIases in Lotus japonicus         [PDF]

Plant Physiology, 2009
Abstract The cis/trans isomerization of the peptide bond preceding proline is an intrinsically slow process, although important in many biological processes in both prokaryotes and eukaryotes. In vivo, this isomerization is catalyzed by peptidyl-prolyl cis/trans-isomerases (PPIases).
Kouri, Evangelia D., Labrou, Nikolaos E., Garbis, Spiros D., Kalliampakou, Katerina I., Stedel, Catalina, Dimou, Maria, Udvardi, Michael K., Katinakis, Panagiotis, Flemetakis, Emmanouil   +8 more
openaire   +4 more sources

Data_Sheet_1_Distribution of Peptidyl-Prolyl Isomerase (PPIase) in the Archaea.docx

, 2021
Cis-trans isomerization of the peptide bond prior to proline is an intrinsically slow process but plays an essential role in protein folding. In vivo cis-trans isomerization reaction is catalyzed by Peptidyl-prolyl isomerase (PPIases), a category of ...
Anchal (11534377), Manisha Goel (3420299), Vineeta Kaushik (11534380)   +2 more
core   +1 more source

Characterization of Peptidyl-Prolyl Cis-Trans Isomerase- and Calmodulin-Binding Activity of a Cytosolic Arabidopsis thaliana Cyclophilin AtCyp19-3. [PDF]

PLoS ONE, 2015
Cyclophilins, which bind to immunosuppressant cyclosporin A (CsA), are ubiquitous proteins and constitute a multigene family in higher organisms. Several members of this family are reported to catalyze cis-trans isomerisation of the peptidyl-prolyl bond,
Gundeep Kaur, Supreet Singh, Harpreet Singh, Mrinalini Chawla, Tanima Dutta, Harsimran Kaur, Kyle Bender, W A Snedden, Sanjay Kapoor, Ashwani Pareek, Prabhjeet Singh   +10 more
doaj   +1 more source

The Activity and Specificity of the Outer Membrane Protein Chaperone SurA Are Modulated by a Proline Isomerase Domain

mBio, 2013
SurA is a component of the periplasmic chaperone network that plays a central role in biogenesis of integral outer membrane β-barrel proteins (OMPs) in Escherichia coli.
Dante P. Ricci, Jaclyn Schwalm, Michelle Gonzales-Cope, Thomas J. Silhavy   +3 more
doaj   +1 more source

Cyclophilin J is a novel peptidyl-prolyl isomerase and target for repressing the growth of hepatocellular carcinoma. [PDF]

PLoS ONE, 2015
Cyclophilin J (CYPJ) is a new member of the peptidyl-prolyl cis/trans-isomerase (PPIase) identified with upregulated expression in human glioma. However, the biological function of CYPJ remained unclear.
Jian Chen, Shuai Chen, Jiahui Wang, Mingjun Zhang, Zhaohua Gong, Youheng Wei, Li Li, Yuanyuan Zhang, Xuemei Zhao, Songmin Jiang, Long Yu   +10 more
doaj   +1 more source

Roles of peptidyl prolyl isomerase Pin1 in viral propagation

Frontiers in Cell and Developmental Biology, 2022
Peptidyl-prolyl isomerase (PPIase) is a unique enzyme that promotes cis-trans isomerization of a proline residue of a target protein. Peptidyl-prolyl cis-trans isomerase NIMA (never in mitosis A)-interacting 1 (Pin1) is a PPIase that binds to the pSer ...
Machi Kanna, Yusuke Nakatsu, Takeshi Yamamotoya, Jeffrey Encinas, Hisanaka Ito, Takayoshi Okabe, Tomoichiro Asano, Takemasa Sakaguchi   +7 more
doaj   +1 more source

Novel cycloheximide derivatives targeting the moonlighting protein Mip exhibit specific antimicrobial activity against Legionella pneumophila

Frontiers in Bioengineering and Biotechnology, 2015
Mip (macrophage infectivity potentiator) and Mip-like proteins are virulence factors in a wide range of pathogens including Legionella pneumophila. These proteins belong to the FK506 binding protein (FKBP) family of peptidyl-prolyl-cis/trans-isomerases ...
Janine eRasch, Martin eTheuerkorn, Can eÜnal, Can eÜnal, Natascha eHeinsohn, Stefan eTran, Gunter eFischer, Gunter eFischer, Matthias eWeiwad, Matthias eWeiwad, Michael eSteinert, Michael eSteinert   +11 more
doaj   +1 more source

Cyclohexyl ketone inhibitors of Pin1 dock in a trans-diaxial cyclohexane conformation. [PDF]

PLoS ONE, 2012
Cyclohexyl ketone substrate analogue inhibitors (Ac-pSer-Ψ[C = OCH]-Pip-tryptamine) of Pin1, the cell cycle regulatory peptidyl-prolyl isomerase (PPIase), were designed and synthesized as potential electrophilic acceptors for the Pin1 active site Cys113 ...
Guoyan G Xu, Carla Slebodnick, Felicia A Etzkorn   +2 more
doaj   +1 more source

Flanking N- and C-terminal domains of PrsA in Streptococcus suis type 2 are crucial for inducing cell death independent of TLR2 recognition

Virulence, 2023
Streptococcus suis type 2 (SS2), a major emerging/re-emerging zoonotic pathogen found in humans and pigs, can cause severe clinical infections, and pose public health issues.
Xiaowu Jiang, Guijun Yu, Lexin Zhu, Abubakar Siddique, Dongbo Zhan, Linhua Zhou, Min Yue   +6 more
doaj   +1 more source