Gears-In-Motion: The Interplay of WW and PPIase Domains in Pin1 [PDF]
Frontiers in Oncology, 2018 Pin1 belongs to the family of the peptidyl-prolyl cis-trans isomerase (PPIase), which is a class of enzymes that catalyze the cis/trans isomerization of the Proline residue. Pin1 is unique and only catalyzes the phosphorylated Serine/Threonine-Proline (S/
Yew Mun Lee, Yih-Cherng Liou
doaj +4 more sources
PpiA, a surface PPIase of the cyclophilin family in Lactococcus lactis.
PLoS ONE, 2012 BackgroundProtein folding in the envelope is a crucial limiting step of protein export and secretion. In order to better understand this process in Lactococcus lactis, a lactic acid bacterium, genes encoding putative exported folding factors like ...
Nicolas Trémillon +10 more
doaj +8 more sources
Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex [PDF]
Nature Communications, 2018 AbstractThe molecular chaperone Hsp90 is critical for the maintenance of cellular homeostasis and represents a promising drug target. Despite increasing knowledge on the structure of Hsp90, the molecular basis of substrate recognition and pro-folding by Hsp90/co-chaperone complexes remains unknown.
Javier Oroz +13 more
openaire +11 more sources
NMR assignments of the FKBP-type PPIase domain of FKBP42 from Arabidopsis thaliana [PDF]
Biomolecular NMR Assignments, 2011 The Atfkbp42 gene is associated with reduced and disoriented growth of Arabidopsis thaliana. Resonance assignments are reported for the FKBP-type PPIase domain of AtFKBP42. Signal intensities reveal an additional structure element that is atypical for such FKBP domains.
Burgardt Noelia Inés +4 more
openaire +6 more sources
Update on the Neisseria Macrophage Infectivity Potentiator-Like PPIase Protein
Frontiers in Cellular and Infection Microbiology, 2022 Neisseria pathogens express a Macrophage Infectivity Potentiator Protein (MIP), which belongs to the FK506 binding protein (FKBP) family of proteins that exhibit peptidyl-prolyl cis/trans isomerase (PPIase) activity.
Myron Christodoulides
doaj +3 more sources
PPIase activities and interaction partners of FK506‐binding proteins in the wheat thylakoid
Physiologia Plantarum, 2011 FK506‐binding proteins (FKBPs) and cyclophilins, collectively called immunophilins, conserve peptidyl‐prolyl cis/trans isomerase (PPIase) active sites, although many lack PPIase activity. The chloroplast thylakoid contains a large proportion of the plant immunophilin family, but their functions within this compartment are unclear.
Gollan, Peter J. +2 more
openaire +4 more sources
Nuclear import of Pin1 is mediated by a novel sequence in the PPIase domain [PDF]
FEBS Letters, 2008 MINT‐6803345: St3 (uniprotkb:P40763) and importin alpha 5 (uniprotkb:P52294) physically interact (MI:0218) by anti tag coimmunoprecipitation (MI:0007)
Lufei, Chengchen, Cao, Xinmin
openaire +3 more sources
Introduction to Peptidyl-Prolyl cis/trans Isomerase (PPIase) Series [PDF]
Biomolecules, 2019 About 30 years after the discovery of peptidyl-prolyl cis/trans isomerases (PPIases), research on this group of proteins has become somewhat calmer than it used to be, but it still generates lots of interest [...]
Andrzej Galat
doaj +3 more sources
HSP-90/kinase complexes are stabilized by the large PPIase FKB-6 [PDF]
Scientific Reports, 2021 Protein kinases are important regulators in cellular signal transduction. As one major type of Hsp90 client, protein kinases rely on the ATP-dependent molecular chaperone Hsp90, which maintains their structure and supports their activation.
Siyuan Sima +7 more
doaj +4 more sources
PrsA2 (CD630_35000) of Clostridioides difficile Is an Active Parvulin-Type PPIase and a Virulence Modulator [PDF]
Frontiers in Microbiology, 2018 Clostridioides difficile is the main cause for nosocomial antibiotic associated diarrhea and has become a major burden for the health care systems of industrial countries.
Can Murat Ünal +11 more
doaj +2 more sources