Results 81 to 90 of about 3,959 (198)
The b-subunit of pea stem mitochondrial ATP synthase exhibits PPiase activity
, 2003 A soluble protein with a molecular mass of 55 kDa has been purified from etiolated pea stem mitochondria. The protein exhibits a Mg2+-requiring PPiase activity, with an optimum at pH 9.0, which is not stimulated by monovalent cations, butinhibited by F2 ...
ZANCANI, Marco +6 more
core +1 more source
Scientific Reports, 2019 Pin1, a polypeptide proline isomerase parvulin, plays a key role in Alzheimer’s disease (AD), common tumors and cancers. Two conservative histidine residues, His59 and His157, are important for maintaining the stability of the PPIase domain.
Wang Wang +6 more
doaj +1 more source
Molecules, 2017 Allosteric communication among domains in modular proteins consisting of flexibly linked domains with complimentary roles remains poorly understood. To understand how complementary domains communicate, we have studied human Pin1, a representative modular
Jing Wang +5 more
doaj +1 more source
Plant, Cell &Environment, Volume 49, Issue 3, Page 1598-1616, March 2026.ABSTRACT Phosphate (Pi) is an essential macronutrient for plant development that is often limited in soil. Plants have evolved dynamic biochemical, physiological and morphological adaptations to cope with Pi deficiency, known as the Pi starvation response (PSR).
Milena A. Smith +5 more
wiley +1 more source
Solution structural analysis of the single-domain parvulin TbPin1. [PDF]
PLoS ONE, 2012 Pin1-type parvulins are phosphorylation-dependent peptidyl-prolyl cis-trans isomerases. Their functions have been widely reported to be involved in a variety of cellular responses or processes, such as cell division, transcription, and apoptosis, as well
Lifang Sun +6 more
doaj +1 more source
Advanced Science, Volume 13, Issue 4, 19 January 2026.Summary diagram for the role of CypA in chemoresistance in non‐small cell lung cancer (NSCLC). CypA is overexpressed in chemoresistance NSCLC and drives therapeutic evasion by competitively binding to the K37 site of SLC7A11, thereby blocking TRIM3 mediated K11‐linked ubiquitination and proteasomal degradation, ultimately inhibiting lipid peroxidation ...
Zhongcheng Wang +9 more
wiley +1 more source
Peptidylprolyl Isomerases as In Vivo Carriers for Drugs That Target Various Intracellular Entities
Biomolecules, 2017 Analyses of sequences and structures of the cyclosporine A (CsA)-binding proteins (cyclophilins) and the immunosuppressive macrolide FK506-binding proteins (FKBPs) have revealed that they exhibit peculiar spatial distributions of charges, their overall ...
Andrzej Galat
doaj +1 more source
Food Science &Nutrition, Volume 14, Issue 1, January 2026.This study explored malate‐accumulation mechanisms in “Hujingmilu” peaches under different storage conditions. Low temperature (LT) delayed firmness decline and maintained higher malate. Transcriptomics showed malate biosynthetic genes weakly correlate with malate levels, while proton pump and transporter genes were up‐regulated under LT.
Hongfang Cai +6 more
wiley +1 more source
Protein Science, Volume 34, Issue 12, December 2025.Abstract Ion channel activity is intricately linked to the surrounding lipid environment, yet the molecular effects of lipid‐mediated regulation remain largely understudied. Here, we show that membrane‐forming phospholipids, which are known to modulate the activity of the cyclic nucleotide‐gated channel SthK from Spirochaeta thermophila, exhibit ...
Ashley J. Newton +3 more
wiley +1 more source
A Family of Novel Cyclophilins, Conserved in the Mimivirus Genus of the Giant DNA Viruses
Computational and Structural Biotechnology Journal, 2018 The cyclophilin (abbreviated here as CYN) family represents a large group of protein prolyl isomerase (PPIase), many of which are also chaperones that promote proper folding of a large variety of client proteins. Over the past few years, megaviruses with
Sailen Barik
doaj +1 more source