Results 81 to 90 of about 3,214 (169)

A Functional Analysis of the Cyclophilin Repertoire in the Protozoan Parasite Trypanosoma Cruzi

Biomolecules, 2018
Trypanosoma cruzi is the etiological agent of Chagas disease. It affects eight million people worldwide and can be spread by several routes, such as vectorborne transmission in endemic areas and congenitally, and is also important in non-endemic regions ...
Alina E. Perrone, Natalia Milduberger, Alicia G. Fuchs, Patricia L. Bustos, Jacqueline Bua   +4 more
doaj   +1 more source

Identification and comparative analysis of sixteen fungal peptidyl-prolyl cis/trans isomerase repertoires

BMC Genomics, 2006
Background The peptidyl-prolyl cis/trans isomerase (PPIase) class of proteins is present in all known eukaryotes, prokaryotes, and archaea, and it is comprised of three member families that share the ability to catalyze the cis/trans isomerisation of a ...
Pemberton Trevor J
doaj   +1 more source

PPIase catalysis by human FK506-binding protein proceeds through a conformational twist mechanism.

Journal of Biological Chemistry, 1992
FK506-binding protein (FKBP) catalyzes the cis-trans isomerization of the peptidyl-prolyl amide bond (the PPIase reaction) and is the major intracellular receptor for the immunosuppressive drugs FK506 and rapamycin. One mechanism proposed for catalysis of the PPIase reaction requires attack of an enzyme nucleophile on the carbonyl carbon of the ...
S T, Park, R A, Aldape, O, Futer, M T, DeCenzo, D J, Livingston   +4 more
openaire   +2 more sources

Non-Catalytic Participation of the Pin1 Peptidyl-Prolyl Isomerase Domain in Target Binding

Frontiers in Physiology, 2013
Pin1 is a phosphorylation-dependent peptidyl-prolyl isomerase that has the potential to add an additional level of regulation within protein kinase mediated signaling pathways.
Brendan Tooke Innes, Melanie L. Bailey, Christopher J Brandl, Brian H. Shilton, David William Litchfield   +4 more
doaj   +1 more source

Dual client binding sites in the ATP-independent chaperone SurA

Nature Communications
The ATP-independent chaperone SurA protects unfolded outer membrane proteins (OMPs) from aggregation in the periplasm of Gram-negative bacteria, and delivers them to the β-barrel assembly machinery (BAM) for folding into the outer membrane (OM ...
Bob Schiffrin, Joel A. Crossley, Martin Walko, Jonathan M. Machin, G. Nasir Khan, Iain W. Manfield, Andrew J. Wilson, David J. Brockwell, Tomas Fessl, Antonio N. Calabrese, Sheena E. Radford, Anastasia Zhuravleva   +11 more
doaj   +1 more source

Screening for PPIase Pin1 Inhibitors

KAGAKU TO SEIBUTSU, 2011
MORI, Tadashi, UCHIDA, Takafumi
openaire   +2 more sources

Optimization of the antiviral spectrum of cyclophilin inhibitors targeting respiratory viruses

Antimicrobial Agents and Chemotherapy
We evaluated the antiviral activity of a library of 36 urea-based small-molecule cyclophilin inhibitors (SMCypIs) against human respiratory syncytial virus (hRSV) and human metapneumovirus (hMPV).
Laurent Softic, Bryan Jimenez-Araya, Nazim Ahnou, Maxime Duval, Quentin Nevers, Rozenn Brillet, Jean-Francois Guichou, Christophe Rodriguez, Patrice Bruscella, Jean-Michel Pawlotsky, Slim Fourati, Abdelhakim Ahmed-Belkacem   +11 more
doaj   +1 more source

Editorial: Peptidyl-prolyl cis/trans isomerases (PPIases) in host-pathogen interactions

Frontiers in Cellular and Infection Microbiology, 2022
openaire   +3 more sources

Mapping Phosphorylation-Specific Pin1-CRMP2 Interactions Using an Integrated Mass Spectrometry Approach. [PDF]

ACS Chem Biol
Kay DF, Brooks NJ, Caulton SG, Jayasekera HS, Lovering AL, Leney AC.   +5 more
europepmc   +1 more source

Retraction: The HBV core protein and core particle both bind to the PPiase Par14 and Par17 to enhance their stabilities and HBV replication. [PDF]

Front Microbiol
Frontiers Editorial Office.
europepmc   +1 more source