Results 91 to 100 of about 3,959 (198)
Small Methods, Volume 9, Issue 12, December 1, 2025.A novel approach is developed to pancreatic cancer screening by targeting the cyclophili‐B (CypB)protein using a molecularly imprinted polymer with the electrode material containing Pt single‐atom‐doped/SeS2‐Ti3CNTx MXene. The quantification of CypB in pancreatic cancer tissues provide an insight into the association of CypB with pancreatic cancer ...
Sathish Panneer Selvam +3 more
wiley +1 more source
The Multiple Roles of Peptidyl Prolyl Isomerases in Brain Cancer
Biomolecules, 2018 Peptidyl prolyl isomerases (PPIases) are broadly expressed enzymes that accelerate the cis-trans isomerization of proline peptide bonds. The most extensively studied PPIase family member is protein interacting with never in mitosis A1 (PIN1), which ...
Stefano Stifani
doaj +1 more source
The Concise Guide to PHARMACOLOGY 2025/26: Enzymes
British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +31 more
wiley +1 more source
Journal of medicinal chemistry, 2016 Peptidyl-proline isomerases (PPIases) are a chaperone superfamily comprising the FK506-binding proteins (FKBPs), cyclophilins, and parvulins. PPIases catalyze the cis/trans isomerization of proline, acting as a regulatory switch during folding, activation, and/or degradation of many proteins.
Dunyak, Bryan M, Gestwicki, Jason E
openaire +4 more sources
Human cyclophilin 40 unravels neurotoxic amyloids.
PLoS Biology, 2017 The accumulation of amyloidogenic proteins is a pathological hallmark of neurodegenerative disorders. The aberrant accumulation of the microtubule associating protein tau (MAPT, tau) into toxic oligomers and amyloid deposits is a primary pathology in ...
Jeremy D Baker +18 more
doaj +1 more source
Citrullination in Tumor Metastasis, Inside and Outside the Cells
Cancer Science, Volume 116, Issue 12, Page 3239-3249, December 2025.ABSTRACT Tumor metastasis remains a poor prognosis because it occurs in all tissues and is difficult to diagnose or prevent before metastatic tumor nodules form. Metastasis is a multi‐step process involving tumor cells, bone marrow‐derived cells, and tissue resident cells, making it a biological three‐body problem.
Takeshi Tomita +2 more
wiley +1 more source
British Journal of Pharmacology, Volume 182, Issue 22, Page 5647-5669, November 2025.Background and Purpose Chronic liver disease and hepatic fibrosis constitute a threat to global health. Clinical translation of preclinical research has been limited, highlighting an urgent need for novel treatments. Cyclophilin inhibitors have shown beneficial effects in liver disease; however, the underlying mechanism of action and the effect across ...
Una Rastovic +24 more
wiley +1 more source
PPIase activity of purified recombinant fusion protein AtCyp19-3
, 2015 (A) Hydrolysis of N-succinyl-ala-ala-pro-phe-p-nitroanilidine (peptidyl prolyl cis-trans isomerase or PPIase activity) in the presence of 4.34 nM of recombinant AtCyp19-3 and 52.4 nM and 65.87 nM each of AtCyp19-3(35–176) and AtCyp19-3(71–176) proteins ...
Sanjay Kapoor (43319) +10 more
core +1 more source
, 2010 Recombinant expression of eukaryotic proteins in bacteria often results in misfolding and aggregation. The ribosome-binding Trigger factor (TF) is the first molecular chaperone that interacts with nascent polypeptide chains in bacteria. Here we show that
Etchells, Stephanie A. +14 more
core +1 more source
A Functional Analysis of the Cyclophilin Repertoire in the Protozoan Parasite Trypanosoma Cruzi
Biomolecules, 2018 Trypanosoma cruzi is the etiological agent of Chagas disease. It affects eight million people worldwide and can be spread by several routes, such as vectorborne transmission in endemic areas and congenitally, and is also important in non-endemic regions ...
Alina E. Perrone +4 more
doaj +1 more source