Results 81 to 90 of about 2,483 (155)

Nrf2 activation by pyrroloquinoline quinone inhibits natural aging‐related intervertebral disk degeneration in mice

Aging Cell, Volume 23, Issue 8, August 2024.
This study sheds light on the preventive effects of dietary PQQ supplementation on oxidative stress, cellular senescence, and extracellular matrix (ECM) degradation in nucleus pulposus cells (NPCs) through Keap1–Nrf2 signaling‐mediated stress response and Wnt5a upregulation, thus preventing aging‐related IVDD.
Qi Xue, Jie Li, Ran Qin, Mingying Li, Yiping Li, Jing Zhang, Rong Wang, David Goltzman, Dengshun Miao, Renlei Yang   +9 more
wiley   +1 more source

Rare earth elements in biology: From biochemical curiosity to solutions for extractive industries

Microbial Biotechnology, Volume 17, Issue 6, June 2024.
To meet society's demands for technologies that use rare earth elements (including those that allow a decarbonized society), we need to increase the volume and efficiency of extraction by mining and recycling. Microbial rare earth biochemistry offers numerous enabling biotechnologies to achieve this. Abstract Rare earth elements (REEs) are critical for
Raquel A. Rocha, Kirill Alexandrov, Colin Scott   +2 more
wiley   +1 more source

Mononuclear binding and catalytic activity of europium(III) and gadolinium(III) at the active site of the model metalloenzyme phosphotriesterase

Acta Crystallographica Section D, Volume 80, Issue 4, Page 289-298, April 2024.
The crystal structures of europium(III)‐ and gadolinium(III)‐bound phosphotriesterase are presented along with esterase activity data for the lanthanide‐bound enzymes.Lanthanide ions have ideal chemical properties for catalysis, such as hard Lewis acidity, fast ligand‐exchange kinetics, high coordination‐number preferences and low geometric ...
Callum W. Breeze, Yuji Nakano, Eleanor C. Campbell, Rebecca L. Frkic, David W. Lupton, Colin J. Jackson   +5 more
wiley   +1 more source

Evaluation of an advanced antioxidant and double‐conjugated retinoid/AHA cream in participants with FST IV–V

Journal of Cosmetic Dermatology, Volume 23, Issue 4, Page 1291-1297, April 2024.
Abstract Background Topical antioxidants and retinoids are foundational components of an effective skincare regimen. Pyrroloquinoline quinone (PQQ) is a potent free radical scavenger that supports efficient mitochondrial energy creation. An advanced antioxidant combines topical allyl PQQ with existing WEL antioxidant technology (TAP) to comprehensively
Pearl E. Grimes, Diane B. Nelson
wiley   +1 more source

The pyrroloquinoline quinone biosynthesis pathway revisited: A structural approach [PDF]

, 2008
Background The biosynthesis pathway of Pyrroloquinoline quinone, a bacterial redox active cofactor for numerous alcohol and aldose dehydrogenases, is largely unknown, but it is proven that at least six genes in Klebsiella pneumoniae (PqqA-F) are required,
Metlitzky, Moritz, Puehringer, Sandra, Schwarzenbacher, Robert   +2 more
core   +3 more sources

X-ray crystallographic studies of two bacterial quinoproteins. Methylamine Dehydrogenase and Quinohaemoprotein Alcohol Dehydrogenase [PDF]

, 1994
For the catalysis of reactions involving the transfer of electrons enzymes utilize either metal ions or special organic compounds called cofactors. A group of enzymes, known as quinoproteins, makes use of cofactors that contain a quinone function.
Huizinga, Eric Geert
core   +2 more sources

Bacterias solubilizadoras de fosfato y sus potencialidades de uso en la promoción del crecimiento de cultivos de importância económica [PDF]

, 2015
La mayoría de los suelos tropicales y subtropicales son deficientes en fósforo biodisponible, por lo que el empleo de bacterias promotoras del crecimiento vegetal, principalmente las solubilizadoras de fosfato, pueden reducir el uso de fertilizantes ...
BALDANI, V. L. D., DIAZ-DE LA OSA, A., FE-PÉREZ, Y. de la, HERNÁNDEZ-RODRIGUEZ, A., MARULANDA-MORENO, S., RESTREPO-FRANCO, G. M.   +5 more
core   +1 more source

Eliciting Clavulanic Acid Biosynthesis: The Impact of Bacillus velezensis FZB42 on the Metabolism of Streptoyces clavuligerus ATCC 27064

Metabolites
Background/Objectives: Clavulanic acid (CA) is produced by cell suspension cultures of Streptomyces clavuligerus ATCC 27064, and is widely used as a beta-lactamase inhibitor to combat antibiotic resistance.
Luisa F. Patiño, Carlos Caicedo-Montoya, Laura Pinilla-Mendoza, Jaison H. Cuartas, Rigoberto Ríos-Estepa   +4 more
doaj   +1 more source

Rapid extracellular acidification induced by glucose metabolism in non-proliferating cells of Serratia marcescens [PDF]

, 2010
The addition of glucose or other sugars to resting cells of Serratia marcescens induced rapid acidification of the extracellular medium. This acidification was due to the catabolism of sugars.
José G. Lorén, Montserrat Solé, Núria Rius   +2 more
core   +2 more sources

Characteristic Reaction Mode of Cofactor PQQ toward Nucleophiles

Characteristic Reaction Mode of Cofactor PQQ toward Nucleophiles
[Abstract] The characteristic reaction mode of coenzyme PQQ toward nucleophiles such as alcohols, amines, and hydrazines are surveyed. The selectivity of addition position of nucleophiles to the carbonyl group of PQQ was affected by reaction conditions and substituents of nucleophiles. Reaction mechanisms were discussed.
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