Effects of pyrroloquinoline quinone and imidazole pyrroloquinoline on biological activities and neural functions [PDF]
Heliyon, 2020 Pyrroloquinoline quinone (PQQ) is contained in fruits and vegetables and in human breast milk. It has been reported that PQQ has high reactivity and changes to an imidazole structure (imidazole pyrroloquinoline) by a reaction with an amino acid at a high
Yasue Yamada, Kazuto Ikemoto
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Protective effects of pyrroloquinoline quinone in brain folate deficiency [PDF]
Fluids and Barriers of the CNS, 2023 Background Folates (Vitamin B9) are critical for normal neurodevelopment and function, with transport mediated by three major pathways: folate receptor alpha (FRα), proton-coupled folate transporter (PCFT), and reduced folate carrier (RFC).
Vishal Sangha +3 more
doaj +2 more sources
No effect of pyrroloquinoline quinone on mouse body weight and energy metabolism with the concomitant increase in mitochondrial biogenesis and antioxidant ability [PDF]
Metabolism OpenPyrroloquinoline quinone (PQQ) stimulates mitochondrial biogenesis and exhibits antioxidant properties. Since mitochondria play a crucial role in energy generation and metabolism, the present study aims to clarify whether PQQ is able to modulate energy ...
Lijun Zhang +10 more
doaj +2 more sources
Pyrroloquinoline-quinone to reduce fat accumulation and ameliorate obesity progression [PDF]
Frontiers in Molecular Biosciences, 2023 Obesity is a major health concern worldwide, and its prevalence continues to increase in several countries. Pyrroloquinoline quinone (PQQ) is naturally found in some foods and is available as a dietary supplement in its disodium crystal form.
Nur Syafiqah Mohamad Ishak +1 more
doaj +2 more sources
Pyrroloquinoline Quinone Inhibits Rotenone-Induced Microglia Inflammation by Enhancing Autophagy
Molecules, 2020 Neuroinflammation is a feature common to neurodegenerative diseases, such as Parkinson’s disease (PD), which might be responsive to therapeutic intervention.
, Mi Shen, Fei Ding
exaly +3 more sources
Pyrroloquinoline quinone: a potential neuroprotective compound for neurodegenerative diseases targeting metabolism [PDF]
Neural Regeneration ResearchPyrroloquinoline quinone is a quinone described as a cofactor for many bacterial dehydrogenases and is reported to exert an effect on metabolism in mammalian cells/tissues.
Alessio Canovai, Pete A. Williams
doaj +2 more sources
Neuroprotective role of pyrroloquinoline quinone in folate deficiency-induced blood-brain barrier disruption [PDF]
Fluids and Barriers of the CNSHealthy neurodevelopment requires adequate folates (vitamin B9), which are critical for key biosynthetic and homeostatic processes in the central nervous system (CNS).
Sara Aboulhassane +3 more
doaj +2 more sources
The effects of pyrroloquinoline quinone and nicotinamide mononucleotide supplementation on interoception following acute exhaustive exercise: a randomised, double-blind, placebo-controlled study [PDF]
Scientific ReportsInteroception, the process by which the nervous system perceives and interprets internal bodily signals, is essential for athletes to effectively modulate motor decisions but may be impaired after exhaustive exercise.
Chenxi Zhao +5 more
doaj +2 more sources
Biomolecules, 2021 Pyrroloquinoline quinone (PQQ) is associated with biological processes such as mitochondriogenesis, reproduction, growth, and aging. In addition, PQQ attenuates clinically relevant dysfunctions (e.g., those associated with ischemia, inflammation and ...
Rb Rucker Or R Rucker +2 more
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Pyrroloquinoline quinone inhibits PCSK9-NLRP3 mediated pyroptosis of Leydig cells in obese mice [PDF]
Cell Death and Disease, 2023 Abnormal lipid metabolism and chronic low-grade inflammation are the main traits of obesity. Especially, the molecular mechanism of concomitant deficiency in steroidogenesis-associated enzymes related to testosterone (T) synthesis of obesity dominated a ...
Jinyuan Wang +21 more
doaj +2 more sources