Results 11 to 20 of about 5,329 (163)

Pyrroloquinoline quinone inhibits PCSK9-NLRP3 mediated pyroptosis of Leydig cells in obese mice [PDF]

Cell Death and Disease, 2023
Abnormal lipid metabolism and chronic low-grade inflammation are the main traits of obesity. Especially, the molecular mechanism of concomitant deficiency in steroidogenesis-associated enzymes related to testosterone (T) synthesis of obesity dominated a ...
Jinyuan Wang, Shun Zhang, Linlin Hu, Yan Wang, Ke Liu, Jianghua Le, Yongpeng Tan, Tianlong Li, Haoxuan Xue, Yanhong Wei, Ou Zhong, Junhui He, Dan Zi, Xin Lei, Renhe Deng, Yafei Luo, Masong Tang, Mingxuan Su, Yichang Cao, Qingyou Liu, Zhihan Tang, Xiaocan Lei   +21 more
doaj   +2 more sources

Dietary pyrroloquinoline quinone and spermidine in healthy longevity: targeting the hallmarks of aging [PDF]

Frontiers in Aging
BackgroundAging is a multifaceted biological process driven by interconnected cellular and molecular hallmarks. As geroscience increasingly prioritizes healthspan over lifespan, nutritional interventions targeting multiple aging mechanisms have gained ...
Tomoe Numaguchi, Mai Nakamura, Tomoyo Koshizawa, Nur Syafiqah Mohamad Ishak, Katsuyuki Hashimoto   +4 more
doaj   +2 more sources

Pyrroloquinoline Quinone Improved Boar Sperm Quality via Maintaining Mitochondrial Function During Cryopreservation [PDF]

Antioxidants
Due to oxidative damage and mitochondrial dysfunction, boar semen cryopreservation remains a significant challenge. This study investigates the effects of pyrroloquinoline quinone (PQQ), a mitochondrial-targeted antioxidant, on the post-thaw boar sperm ...
Shanpeng Wang, Qi Wang, Lingjiang Min, Hailiang Cao, Adedeji O. Adetunji, Kaifeng Zhou, Zhendong Zhu   +6 more
doaj   +2 more sources

Pyrroloquinoline-Quinone Is More Than an Antioxidant: A Vitamin-like Accessory Factor Important in Health and Disease Prevention

Biomolecules, 2021
Pyrroloquinoline quinone (PQQ) is associated with biological processes such as mitochondriogenesis, reproduction, growth, and aging. In addition, PQQ attenuates clinically relevant dysfunctions (e.g., those associated with ischemia, inflammation and ...
Karen R Jonscher, Robert B Rucker, Jonscher Karen R   +2 more
exaly   +3 more sources

Deep Learning‐Driven Exploration of Pyrroloquinoline Quinone Neuroprotective Activity in Alzheimer's Disease [PDF]

Advanced Science
Alzheimer's disease (AD) is a pressing concern in neurodegenerative research. To address the challenges in AD drug development, especially those targeting Aβ, this study uses deep learning and a pharmacological approach to elucidate the potential of ...
Xinuo Li, Yuan Sun, Zheng Zhou, Jinran Li, Sai Liu, Long Chen, Yiting Shi, Min Wang, Zheying Zhu, Guangji Wang, Qiulun Lu   +10 more
doaj   +2 more sources

Dietary pyrroloquinoline quinone hinders aging progression in male mice and D-galactose-induced cells [PDF]

Frontiers in Aging
Background: Understanding and promoting healthy aging has become a necessity in the modern world, where life expectancy is rising. The prospective benefits of the antioxidant pyrroloquinoline quinone (PQQ) in healthy aging are promising.
Nur Syafiqah Mohamad Ishak, Midori Kikuchi, Kazuto Ikemoto   +2 more
doaj   +2 more sources

Metabolic and Biochemical Effects of Pyrroloquinoline Quinone (PQQ) on Inflammation and Mitochondrial Dysfunction: Potential Health Benefits in Obesity and Future Perspectives [PDF]

Antioxidants
Obesity is defined as a complex, systemic disease characterized by excessive and dysfunctional adipose tissue, leading to adverse health effects. This condition is marked by low-grade inflammation, oxidative stress, and metabolic abnormalities, including
Davide Charrier, Giuseppe Cerullo, Roberta Carpenito, Vincenzo Vindigni, Franco Bassetto, Luca Simoni, Tatiana Moro, Antonio Paoli   +7 more
doaj   +2 more sources

Endophytic Biostimulant Pyrroloquinoline Quinone Enhances Banana Growth and Primes Immunity Against Fusarium Wilt. [PDF]

Physiol Plant
ABSTRACT Pyrroloquinoline quinone (PQQ) is a redox cofactor derived from prokaryotes that participates in various biological processes involving dehydrogenase enzymes. Previous field trials identified a PQQ‐producing endophyte, Burkholderia seminalis 869T2, which enhances banana growth and reduces Fusarium wilt incidence from 24.5% to 3.4%.
Hung SW, Yu MY, Liu CH, Huang TC, Peng JH, Jang NY, Kuo CH, Yang YL, Ho YN, Chiang EI, Hwang HH, Huang CC.   +11 more
europepmc   +2 more sources

The impact of six-week dihydrogen-pyrroloquinoline quinone supplementation on mitochondrial biomarkers, brain metabolism, and cognition in elderly individuals with mild cognitive impairment: a randomized controlled trial [PDF]

The Journal of Nutrition, Health and Aging
Objectives: To assess the impact of medium-term supplementation with dihydrogen and pyrroloquinoline quinone (PQQ) on mitochondrial biomarkers, brain metabolism, and cognition in elderly individuals diagnosed with mild cognitive impairment.
Sonja Baltic, David Nedeljkovic, Nikola Todorovic, Marijana Ranisavljev, Darinka Korovljev, Jelena Cvejic, Jelena Ostojic, Tyler W. LeBaron, Judi Timmcke, Valdemar Stajer, Sergej M. Ostojic   +10 more
doaj   +2 more sources

Protective Effect of Pyrroloquinoline Quinone (PQQ) against Renal Ischemia-Reperfusion Injury in Rat [PDF]

Iranian Journal of Veterinary Surgery, 2023
Ischemia/reperfusion can cause tissue damage and affect organ function. Ischemia-reperfusion injury (IRI) occurs in a variety of clinical manifestations such as stroke, trauma, and surgery.
Elnaz Taheran, Vahid Mohammadi, Rahim Mohammadi   +2 more
doaj   +1 more source