Results 71 to 80 of about 94,951 (115)

Pyrroloquinoline Quinone Reprograms the Single‐Cell Landscape of Immune Aging in Hematopoietic Immune System

Aging Cell, Volume 24, Issue 7, July 2025.
This study demonstrates that aging induces oxidative stress and inflammation in the hematopoietic immune system, resulting in immune homeostasis dysfunction, including alterations in B cells and hematopoietic stem cells, senescent cells (SnCs) accumulation, and senescence‐associated secretory phenotypes (SASPs) production. Notably, the study highlights
Xiuxing Liu, Chun Zhang, Jianjie Lv, Yidan Liu, Chenyang Gu, Yuehan Gao, Wen Ding, Hui Chen, Nanwei Xu, Hongbin Yin, Wenru Su, Zhuping Xu   +11 more
wiley   +1 more source

Pyrroloquinoline Quinone Targets the Allosteric Activation Site of Nicotinamide Phosphoribosyltransferase (NAMPT): Structural Basis and Consequences for NAD⁺ Metabolism in Aging

Applied Sciences
NAD+ depletion is a defining feature of the aging cell, driven by a progressive decline in nicotinamide phosphoribosyltransferase (NAMPT) activity, the rate-limiting enzyme of the NAD+ salvage pathway.
Alessandro Medoro, Sergio Davinelli, Tassadaq Hussain Jafar, Truong Tan Trung, Ciro Costagliola, Gemma Caterina Maria Rossi, Giovanni Scapagnini   +6 more
doaj   +1 more source

Engineered Living Energy Materials

Interdisciplinary Materials, Volume 4, Issue 3, Page 412-455, May 2025.
Engineered living energy materials (ELEMs) are nascent research frontier for enabling sustainable energy conversion and storage. These materials exhibit unique characteristics such as self‐regeneration, biodegradability, environmental response, and evolutionary adaptability. This paper overviews different energy conversion bio‐modules, summarizes their
Xinyi Yuan, Haiyi Xu, Xingwu Liu, Jicong Zhang, Jing Li, Qianyi Liang, Bolin An, Giuseppe Maria Paternò, Minyue Zhang, Yuqing Tang, Chen Zhang, Dake Xu, Chao Zhong, Ke Li, Xinyu Wang   +14 more
wiley   +1 more source

A PQQ-dependent oxidoreductase in Trypanosoma cruzi reveals a novel redox activity in a eukaryotic pathogen

Frontiers in Cellular and Infection Microbiology
Trypanosoma cruzi, the etiological agent of Chagas disease, faces profound nutritional and redox stress throughout its life cycle, requiring exceptional metabolic plasticity for survival across insect and mammalian hosts.
Juan Pablo Gallardo, Juan Pablo Gallardo, Juan Pablo Gallardo, Walter Jesús Lapadula, Micaela Soledad Ossowski, Gabriela Teresa Niemirowicz, Maximiliano Juri Ayub, Karina Andrea Gómez, Karina Andrea Gómez, Mariana Potenza, Mariana Potenza   +10 more
doaj   +1 more source

The natural redox cofactor PQQ enables photocatalytic radical cyclizations

Photoenzymatic catalysis facilitates stereoselective new-to-nature chemistry under mild conditions. In addition to the rational design of artificial photoenzymes, naturally occurring redox enzymes have been repurposed for this approach. Most prominently, flavin-containing cofactors can promote photoredox catalysis in the chiral protein environment ...
Srishti Ballabh Bahukhandi, Andreas Sebastian Klein, Ghulam Mustafa, Maria Weyh, Alexandra Walter, Erling Thyrhaug, Jürgen Hauer, Golo Storch, Cathleen Zeymer   +8 more
openaire   +1 more source

Recent Advances in Enzyme‐based Biofuel Cells Using Glucose Fuel: Achieving High Power Output and Enhanced Operational Stability

Advanced Functional Materials, Volume 35, Issue 16, April 18, 2025.
Effective electron transfer and stable enzyme immobilization, both between enzymes and host electrodes as well as between adjacent enzymes, are crucial for optimizing the biofuel cell (BFC) performance. Recently, efforts have focused on integrating these strategies with porous host electrodes.
Junha Pak, Woojae Chang, Cheong Hoon Kwon, Jinhan Cho   +3 more
wiley   +1 more source

Ameliorative effects of pyrroloquinoline quinone on oxidized fish oil-induced growth retardation, immune suppression, and oxidative stress in yellow catfish Tachysurus fulvidraco

Aquaculture Reports
Fish oil is the primary oil source in aquafeeds, but is susceptible to oxidation during production and storage, thereby leading to oxidative stress in fish.
Xiaona Ma, Licai Wu, Xuli Bao, Ziheng Wu, Qingchao Shi, Chuanjie Qin   +5 more
doaj   +1 more source

Bioinformatic evidence for a widely distributed, ribosomally produced electron carrier precursor, its maturation proteins, and its nicotinoprotein redox partners

BMC Genomics, 2011
Background Enzymes in the radical SAM (rSAM) domain family serve in a wide variety of biological processes, including RNA modification, enzyme activation, bacteriocin core peptide maturation, and cofactor biosynthesis.
Haft Daniel H
doaj   +1 more source

Contrasting Methane, Sulfide and Nitrogen‐Loading Regimes in Bioreactors Shape Microbial Communities Originating From Methane‐Rich Coastal Sediment of the Stockholm Archipelago

Environmental Microbiology, Volume 27, Issue 2, February 2025.
In this study, microbial communities are enriched in brackish anoxic bioreactors with methane, sulfide, nitrate and ammonium. Novel diversity is identified and functionally analysed. ABSTRACT Coastal ecosystems are increasingly exposed to high nutrient loads and salinity intrusions due to rising seawater levels.
Maider J. Echeveste Medrano, Garrett J. Smith, Irene Sánchez‐Andrea, Mike S. M. Jetten, Cornelia U. Welte   +4 more
wiley   +1 more source

Engineered Passive Glucose Uptake in Pseudomonas taiwanensis VLB120 Increases Resource Efficiency for Bioproduction

Microbial Biotechnology, Volume 18, Issue 1, January 2025.
In this study, we heterologously expressed the energy‐independent glucose facilitator protein (Glf) from Zymomonas mobilis to replace the native energy‐demanding glucose transport systems, thereby increasing the metabolic energy efficiency. Implementation of passive glucose uptake in engineered production strains significantly increased product titres ...
Tobias Schwanemann, Nicolas Krink, Pablo I. Nikel, Benedikt Wynands, Nick Wierckx   +4 more
wiley   +1 more source