Results 111 to 120 of about 2,290,098 (252)
"Médiateurs" et prévention VIH/sida [PDF]
, 1999 [Table des matières] 1. Plusieurs modèles de médiateurs. 2. Recommandations. 3. Mediator models. 4. Littérature. 4.1. Exemples de programmes ayant recours à des médiateurs dans le domaine du VIH/sida. 4.2.
Delbos Piot Isabelle (Collab.), +4 more
core
Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells
FEBS Letters, EarlyView.Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López +2 more
wiley +1 more source
Noncommunicable diseases in sub-Saharan Africa: where do they feature in the health research agenda?
Bulletin of the World Health OrganizationThere is no doubt that communicable diseases will remain the predominant health problem for the populations in sub-Saharan Africa, including adults, for the next 10--20 years.
Nigel Unwin +9 more
doaj +1 more source
Rôles et interventions infirmières dans la prévention de la consommation de cannabis auprès des jeunes adolescents scolarisés sur le canton de Genève: travail de Bachelor [PDF]
, 2016 Contexte : La consommation de cannabis chez les adolescents est inquiétante de par les effets qu’elle peut avoir sur leur organisme et la rupture sociale qu’elle peut provoquer.
Ludwig, Catherine +1 more
core
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Regulation and Productivity in the Quebec Manufacturing Sector [PDF]
We investigate the impact of occupational safety and health (OSH) and environmental regulation on the rate of growth of total factor productivity (TFP) in the Quebec manufacturing sector during the 1985-88 period.
Charles Dufour +2 more
core
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source