Results 111 to 120 of about 2,255,048 (250)

The Efficient Liability Sharing Factor For Environmental Disasters: Lessons For Optimal Insurance Regulation [PDF]

Using a structural model of the interactions between governments, firms and insurance companies, we characterise the distortions in environmental liability sharing between firms and insurance companies that the imperfect implementation of government ...
Donatella Porrini, Marcel Boyer
core  

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

"Médiateurs" et prévention VIH/sida [PDF]

, 1999
[Table des matières] 1. Plusieurs modèles de médiateurs. 2. Recommandations. 3. Mediator models. 4. Littérature. 4.1. Exemples de programmes ayant recours à des médiateurs dans le domaine du VIH/sida. 4.2.
Delbos Piot Isabelle (Collab.),, Dubois-Arber, Françoise, Haour-Knipe, Mary, Kessler, Daniel, Meystre-Agustoni, Giovanna   +4 more
core  

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Les interventions publiques nationales en matière d'abus de substances et de dépendances : une revue internationale [PDF]

, 2004
[Table des matières] Résumé. Zusammenfassung. 1. Situation de départ et mandat. 2. Problématique. 3. Questions de recherche. 4. Méthode. 5. Résultats généraux. 6.
Arnaud, Sophie, Ramstein, Tatjana, Zobel, Frank   +2 more
core  

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

A experiência com a Metodologia IRDI em creches: pré-venir um sujeito

Revista Latinoamericana de Psicopatologia Fundamental
A Metodologia IRDI é um dispositivo de avaliação e acompanhamento de bebês de zero a 18 meses na sua constituição psíquica. Foi construído a partir de quatro operações constitutivas: suposição do sujeito, estabelecimento da demanda, alternância presença ...
Andrea Gabriela Ferrari, Paula de Paula Fernandes, Milena da Rosa Silva, Monique Scapinello   +3 more
doaj   +1 more source

Pour une prévention en "actes": En conclusion [PDF]

, 2002
National audienceConfrontée à ce système d’influence à multifacettes, la prévention des conduites dopantes appelle le développement d’une stratégie de prévention portée par les différents acteurs du mouvement sportif car ce qui frappe l’observateur, c ...
Guy, Daniel
core   +1 more source