Results 81 to 90 of about 468,747 (306)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Robust Hybrid Adaptive Control via Enhanced Lyapunov Function for Chaotic Systems with Large Time Delays [PDF]

Control and Optimization in Applied Mathematics
This paper introduces a robust hybrid adaptive control framework for stabilizing chaotic systems under persistent, potentially large time delays. The controller is based on an enhanced Lyapunov–Krasovskii functional that integrates an energy-capturing ...
Mohammad Rashki-Ghalehno, Seyed Mehdi Mirhosseini-Alizamini, Bashir Naderi   +2 more
doaj   +1 more source

On the tasks of the European Stability Mechanism. CEPS Policy Brief No. 235, 8 March 2011 [PDF]

, 2011
At its forthcoming spring meeting, on March 24th-25th, the European Council will consider a comprehensive package of measures that can open a new age of European economic governance: one that is truly collective; capable of enforcing economic policy ...
Carmassi, Jacopo, Micossi, Stefano., Pierce, Fabrizia.   +2 more
core  

Practical Stability of Caputo fractional differential equations by Lyapunov functions

, 2016
The practical stability of a nonlinear nonautonomous Caputo fractional differential equation is studied using Lyapunov like functions. The novelty of this paper is based on the new definition of the derivative of a Lyapunov like function along the given ...
Donal 'Regan, Snezhana G. Hristova, Ravi P. Agarwal, O'Regan, Donal, Hristova, Snezhana G., Agarwal, Ravi P.   +5 more
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Input-to-state stability for discrete-time time-varying systems with applications to robust stabilization of systems in power form [PDF]

, 2005
Input-to-state stability (ISS) of a parameterized family of discrete-time time-varying nonlinear systems is investigated. A converse Lyapunov theorem for such systems is developed.
Laila, D. S., Astolfi, A.,, Nesic, Dragan, Laila, Dina Shona, Astolfi, A., Laila, Dina Shona,   +5 more
core   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

On practical ℎ-observer design for nonlinear non-autonomous dynamical systems with disturbances [PDF]

Archives of Control Sciences
In this paper, a particular form of practical ℎ-observers for piecewise continuous Lipschitz, one-sided piecewise continuous Lipschitz systems and quasi-one-sided piecewise continuous Lipschitz systems is extended to nonlinear non-autonomous dynamical ...
Manel Alaya, Hanen Damak, Nizar Hadj Taieb, Mohamed Ali Hammami   +3 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source