Results 71 to 80 of about 1,214,653 (312)

Personalizing Busulfan-Based Conditioning: Considerations from the American Society for Blood and Marrow Transplantation Practice Guidelines Committee.

Biology of Blood and Marrow Transplantation, 2016
The Practice Guidelines Committee of the American Society of Blood or Marrow Transplantation (ASBMT) sought to develop an evidence-based review about personalizing busulfan-based conditioning. The Committee sought to grade the relevant published studies (
J. Palmer, J. McCune, M. Perales, D. Marks, J. Bubalo, M. Mohty, J. Wingard, A. Paci, Moustapha Hassan, C. Bredeson, J. Pidala, N. Shah, P. Shaughnessy, N. Majhail, J. Schriber, B. Savani, P. Carpenter   +16 more
semanticscholar   +1 more source

2020 Focused Updates to the Asthma Management Guidelines: A Report from the National Asthma Education and Prevention Program Coordinating Committee Expert Panel Working Group

Journal of Allergy and Clinical Immunology, 2020
The 2020 Focused Updates to the Asthma Management Guidelines: A Report from the National Asthma Education and Prevention Program Coordinating Committee Expert Panel Working Group was coordinated and supported by the National Heart, Lung, and Blood ...
M. Cloutier, A. Baptist, K. Blake, E. Brooks, T. Bryant-Stephens, E. DiMango, A. Dixon, K. Elward, T. Hartert, J. Krishnan, D. Ouellette, W. Pace, M. Schatz, N. Skolnik, J. Stout, S. Teach, C. Umscheid, Colin G. Walsh   +17 more
semanticscholar   +1 more source

Who\u27s your expert? Use of an expert opinion survey to inform development of American Psychiatric Association practice guidelines. [PDF]

, 2014
OBJECTIVE: For many clinical questions in psychiatry, high-quality evidence is lacking. Credible practice guidelines for such questions depend on transparent, reproducible, and valid methods for assessing expert opinion.
Fochtmann, Laura J., Kunkle, Robert, Nininger, James E., Plovnick, Robert, Reid, Sara M., Silverman, Joel J., Vergare, Michael J., Yager, Joel   +7 more
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Diretrizes para detecção precoce do câncer de mama no Brasil. II - Novas recomendações nacionais, principais evidências e controvérsias

Cadernos de Saúde Pública, 2018
Resumo: O câncer de mama é a principal causa de morte por câncer em mulheres no Brasil. As novas diretrizes para detecção precoce no Brasil foram elaboradas com base em revisões sistemáticas da literatura sobre riscos e possíveis benefícios de diversas ...
Arn Migowski, Gulnar Azevedo e Silva, Maria Beatriz Kneipp Dias, Maria Del Pilar Estevez Diz, Denise Rangel Sant’Ana, Paulo Nadanovsky   +5 more
doaj   +1 more source

The Delphi and GRADE methodology used in the PSOGI 2018 consensus statement on Pseudomyxoma Peritonei and Peritoneal Mesothelioma

, 2021
Pseudomyxoma Peritonei (PMP) and Peritoneal Mesothelioma (PM) are both rare peritoneal malignancies. Currently, affected patients may be treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy offering long-term survival or even ...
de Hingh, I.,, Deraco, M.,, Glehen, O.,, Govaerts, K.,, Kepenekian, V.,, Kusamura, S.,, Lund University., Lurvink, R.J,, Moran, B.,, PSOGI, Syk, Ingvar,, Van der Speeten, K.,, Villeneuve, L.,   +12 more
core   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Sperm DNA Fragmentation: A Critical Assessment of Clinical Practice Guidelines

The World Journal of Men's Health, 2022
Sperm DNA fragmentation (SDF) is implicated in male infertility and adverse reproductive outcomes. With the publication of many studies regarding the etiologies and contributors to SDF, as well as the effects of SDF, guidelines are necessary to aid ...
Ashok Agarwal, Ala’a Farkouh, Neel Parekh, Armand Zini, Mohamed Arafa, Hussein Kandil, Nick Tadros, Gian Maria Busetto, Rafael Ambar, Sijo Parekattil, Florence Boitrelle, Hassan Sallam, Sunil Jindal, Edmund Ko, Mara Simopoulou, Hyun Jun Park, Mohammad Ali Sadighi, Ramadan Saleh, Jonathan Ramsay, Marlon Martine, Haitham Elbardisi, Juan Alvarez, Giovanni Colpi, Jaime Gosalvez, Donald Evenson, Rupin Shah   +25 more
doaj   +1 more source

Achieving change in primary care—causes of the evidence to practice gap : systematic reviews of reviews [PDF]

, 2015
Acknowledgements The Evidence to Practice Project (SPCR FR4 project number: 122) is funded by the National Institute of Health Research (NIHR) School for Primary Care Research (SPCR). KD is part-funded by the National Institute for Health Research (NIHR)
Dziedzic, Krysia, Eldridge, Sandra, Everitt, Hazel, Kennedy, Anne, Lau, Rosa, Murray, Elizabeth, Ong, Bie Nio, Peacock, Richard, Qureshi, Nadeem, Rogers, Anne, Stevenson, Fiona, Treweek, Shaun   +11 more
core   +3 more sources

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source