Results 71 to 80 of about 153,960 (266)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Assessing the landscape of family medicine in India: A focus on qualification and practice patterns

Journal of Family Medicine and Primary Care
Aims and Objectives: Describe the demographic and professional profiles of the family physicians. 1. To study the factors associated with practice patterns. Methodology: It is a cross-sectional, questionnaire-based study.
Hemavathi Dasappa, Mohan Kubendra, Namiya Jose, Resmi S. Kaimal, Vandana Boobna, S Ramya   +5 more
doaj   +1 more source

Models and theories of prescribing decisions: A review and suggested a new model

Pharmacy Practice, 2017
To date, research on the prescribing decisions of physician lacks sound theoretical foundations. In fact, drug prescribing by doctors is a complex phenomenon influenced by various factors.
Ali Murshid M, Mohaidin Z
doaj   +1 more source

Pap smear practice patterns of family physicians.

Canadian family physician Medecin de famille canadien, 2013
London, Ontario family physicians were surveyed, to compare the frequency of their Pap smear screening and their management of the abnormal smear with the recommendations of the 1982 Task Force report on cervical cancer screening. Considerable variation was observed between the Task Force recommendations and frequency of screening 36-60-year-old women,
T M, Gerace, J F, Sangster
openaire   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Gender Perspectives on Self-Employment Among Israeli Family Physicians: A Qualitative Study

Social Sciences
Background: While previous studies have shown that occupational choices are influenced by traditional gender perceptions, little is known about gender’s role in choosing self-employment among family physicians.
Irit Chudner, Avi Shnider, Omer Gluzman, Hadas Keidar, Motti Haimi   +4 more
doaj   +1 more source

Practice patterns among early-career primary care (ECPC) physicians and workforce planning implications: protocol for a mixed methods study

BMJ Open, 2019
Introduction Canadians report persistent problems accessing primary care despite an increasing per-capita supply of primary care physicians (PCPs). There is speculation that PCPs, especially those early in their careers, may now be working less and/or ...
Richard J Gibson, Tara Sampalli, Tara Kiran, Richard H Glazier, Agnes Grudniewicz, Kimberlyn McGrail, David Snadden, Ian Scott, M Ruth Lavergne, Laurie J Goldsmith, David Rudoler, Emily Gard Marshall, Megan Ahuja, Doug Blackie, Fred Burge, Steve Hawrylyshyn, Lindsay Hedden, Jacalynne Hernandez-Lee, Kathleen Horrey, Mike Joyce, Adrian MacKenzie, Maria Mathews, Rita McCracken, Madeleine McKay, Charmaine McPherson, Goldis Mitra, Gail Tomblin Murphy, Sabrina T Wong   +27 more
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Teaching physicians the GPGP method promotes deprescribing in both inpatient and outpatient settings

Therapeutic Advances in Drug Safety, 2019
Background In complex older patients, inappropriate medication use and polypharmacy (IMUP) are commonplace and increasing exponentially. Reducing IMUP is a challenge in multiple clinical contexts, including acute admission and family practice, due to ...
Aaron Jason Bilek, Yuval Levy, Haneen Kab, Pavel Andreev, Doron Garfinkel   +4 more
doaj   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source