Results 91 to 100 of about 1,577,570 (335)

A pragmatic randomized trial comparing tablet computer informed consent to traditional paper-based methods for an osteoporosis study

Contemporary Clinical Trials Communications, 2016
Objective: Methods to improve informed consent efficiency and effectiveness are needed for pragmatic clinical trials. We compared informed consent using a tablet computer to a paper approach to assess comprehension and satisfaction of patients and clinic
A.H. Warriner, P.J. Foster, A. Mudano, N.C. Wright, M.E. Melton, S.E. Sattui, W. Calmbach, J.R. Curtis, M. Kilgore, C.E. Lewis, W. Pace, K.G. Saag   +11 more
doaj   +1 more source

Clinical trial metadata:Defining and extracting metadata on the design, conduct, results and costs of 125 randomised clinical trials funded by the National Institute for Health Research Health Technology Assessment programme [PDF]

, 2015
Background:  By 2011, the Health Technology Assessment (HTA) programme had published the results of over 100 trials with another 220 in progress. The aim of the project was to develop and pilot ‘metadata’ on clinical trials funded by the HTA programme.  
Cook, Andrew, Davidson, Peter, Milne, Ruairidh, Raftery, James, Stanton, Louise, Turner, David, Young, Amanda   +6 more
core   +2 more sources

Certificates of confidentiality and unexpected complications for pragmatic clinical trials

Learning Health Systems, 2020
The need to protect the confidentiality of research data has long been recognized. One means to help protect research data from use in civil or criminal matters in the United States is a Certificate of Confidentiality (CoC). Until recently, investigators
J. Sugarman, Judith Carrithers
semanticscholar   +1 more source

Association of CDKN2A/B Homozygous Deletion and Extent of Resection With Survival of Patients With WHO CNS5 Grade 4 Astrocytoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives WHO grade 4 astrocytomas are associated with poor prognosis, and their prognostic factors remain controversial. This study aimed to identify the prognostic factors and develop a management algorithm for these patients. Methods This study retrospectively included 151 CNS5 adult grade 4 astrocytomas from two medical centers.
Jiawei Cai, Guanglin Zhu, Qiu He, Chen Luo, Lingyun Zhuo, Xingfu Wang, Yiming Chen, Xiaoyong Chen, Wendong You, Jiaheng Xu, Yuanxiang Lin, Dezhi Kang, Shuai Wu, Zanyi Wu   +13 more
wiley   +1 more source

Improving outcomes in adult patients who self-harm—evaluating a brief psychological intervention in emergency departments (ASSURED): protocol of a randomised controlled clinical trial

Trials
Background Patients with self-harm and suicidal ideation are increasingly presenting in emergency departments (ED) in the UK. Self-harm is the strongest risk factor for suicide.
Rose McCabe, Mimi Suzuki, Sally O’Keeffe, Neil Walker, Richard Hooper, Stefan Priebe, Borislava Mihaylova, Yan Feng, Chris Dickens, Peter Aitken, Vera Araújo Soares, Richard Byng, Domenico Giacco, Navneet Kapur, Will Lee, Peter Riou, Mary Ryan, Alan Simpson, Helen Smith, Lucy Polyanna Goldsmith, Alexandra Elissavet Bakou   +20 more
doaj   +1 more source

Sex Representation in US Stroke Clinical Trials: A Decade of Trends and Challenges

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stroke remains a major cause of disability and mortality in the US, with significant sex‐based disparities, and females remain underrepresented in stroke clinical trials. We aimed to examine sex representation in US‐based stroke clinical trials, identify trial characteristics associated with higher female enrollment (≥ 50%), and ...
Chaitali Dagli, Mudasir Andrabi, Tova Cohen, Pranali G. Patel, Tapasya Katta, Chen Lin   +5 more
wiley   +1 more source

Against pragmatism: on efficacy, effectiveness and the real world

Trials, 2009
Explanatory and pragmatic trials represent ends of a continuum of attitudes about clinical trial design. Recent literature argues that pragmatic trials are more informative about clinical care in the real world. Although there is place for more pragmatic
Kitsios Georgios, Kent David M
doaj   +1 more source

Randomised controlled trials of complex interventions and large-scale transformation of services [PDF]

, 2016
Complex interventions and large-scale transformations of services are necessary to meet the health-care challenges of the 21st century. However, the evaluation of these types of interventions is challenging and requires methodological development ...
Barratt, Helen, Bower, Peter, Campbell, Marion, Moore, Laurence, Zwarenstein, Merrick   +4 more
core   +1 more source

The Adhesive Capsulitis Corticosteroid and Dilation (ACCorD) randomized controlled trial: a feasibility study in primary care

Bone & Joint Open
Aims: Is it feasible to conduct a definitive multicentre trial in community settings of corticosteroid injections (CSI) and hydrodilation (HD) compared to CSI for patients with frozen shoulder?
Livio Di Mascio, Thomas Hamborg, Borislava Mihaylova, Jamila Kassam, Bina Shah, Beth Stuart, Xavier L. Griffin   +6 more
doaj   +1 more source

Group antenatal care (Pregnancy Circles) for diverse and disadvantaged women: study protocol for a randomised controlled trial with integral process and economic evaluations

BMC Health Services Research, 2020
Background Group antenatal care has been successfully implemented around the world with suggestions of improved outcomes, including for disadvantaged groups, but it has not been formally tested in the UK in the context of the NHS.
Meg Wiggins, Mary Sawtell, Octavia Wiseman, Christine McCourt, Sandra Eldridge, Rachael Hunter, Ekaterina Bordea, Connor Mustard, Ainul Hanafiah, Bethan Hatherall, Vivian Holmes, Anita Mehay, Helliner Robinson, Cathryn Salisbury, Lorna Sweeney, Kade Mondeh, Angela Harden   +16 more
doaj   +1 more source