Results 81 to 90 of about 6,158,274 (301)

Research Report 2011 [PDF]

, 2012
The NHMRC Clinical Trials Centre (CTC) at the University of Sydney runs large multicentre investigator-initiated clinical trials, takes part in trials of national and international collaborative trial groups and contributes expertise to trials run by ...
NHMRC Clinical Trials Centre
core  

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Positive predictive value of respiratory infection diagnoses in the Danish National Patient Registry: A post hoc validation analysis of the DANFLU-1 trial

International Journal of Infectious Diseases
Objectives: To validate respiratory infection diagnosis codes in the Danish National Patient Registry (DNPR) in the DANFLU-1 feasibility trial, and to assess whether reperforming effectiveness analyses with validated events altered findings.
Jacob Christensen, Niklas Dyrby Johansen, Katrine Feldballe Bernholm, Julie Inge-Marie Helene Borchsenius, Kira Hyldekær Janstrup, Daniel Modin, Kristoffer Grundtvig Skaarup, Joshua Nealon, Sandrine Samson, Matthew Loiacono, Youjun Huang, Rebecca Harris, Carsten Schade Larsen, Anne Marie Reimer Jensen, Nino Emanuel Landler, Brian L. Claggett, Scott D. Solomon, Gunnar H. Gislason, Lars Køber, Martin J. Landray, Pradeesh Sivapalan, Jens Ulrik Stæhr Jensen, Tor Biering-Sørensen   +22 more
doaj   +1 more source

The ethical justification for inclusion of neonates in pragmatic randomized clinical trials for emergency newborn care

BMC Pediatrics, 2019
Background Research guidelines generally recognize vulnerable populations to include neonates with the aim of enhancing protections from harm. In practice, such guidance results in limiting participation in randomized clinical trials (RCTs).
Dan Kabonge Kaye
doaj   +1 more source

Research Report 2010 [PDF]

, 2011
The NHMRC Clinical Trials Centre at the University of Sydney conducts large multicentre investigator-initiated clinical trials, takes part in trials of national and international collaborative trial groups and contributes expertise to trials run by ...
NHMRC Clinical Trials Centre
core  

CSF Cytokine Network Organization Predicts Progression Independent of Relapse and MRI Activity in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Progression independent of relapse activity is a major determinant of long‐term disability in multiple sclerosis, but its immunopathologic basis remains incompletely understood. We investigated whether relapse‐independent progression in radiologically stable relapsing–remitting multiple sclerosis is associated with distinct ...
Antonio Bruno, Matteo Conti, Ettore Dolcetti, Federica Azzolini, Angela Borrelli, Roberta Fantozzi, Mario Stampanoni Bassi, Giovanni Galifi, Giuseppe Maccarrone, Luca Montaguti, Marco Cervigni, Maddalena Dal Pozzo, Roberto Furlan, Annamaria Finardi, Girolama Alessandra Marfia, Marco Salvetti, Antonella Conte, Fabio Buttari, Diego Centonze, Luana Gilio   +19 more
wiley   +1 more source

Research Report 2004–2005 [PDF]

, 2006
The National Health and Medical Research Council Clinical Trials Centre has the purpose of improving outcomes in health through clinical trials research.
NHMRC Clinical Trials Centre
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Data‐Driven SuStaIn Model of Disability Progression in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether ordinal Subtype and Stage Inference (SuStaIn) applied to routine ALSFRS‐R item scores can identify reproducible disability progression patterns in amyotrophic lateral sclerosis (ALS) and provide clinically meaningful staging.
Giammarco Milella, Veria Vacchiano, Vittorio Velucci, Stefano Zoccolella, Rocco Liguori, Giovanni Defazio   +5 more
wiley   +1 more source

Utility of the APE2 Score as a Diagnostic Tool for Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To retrospectively evaluate the diagnostic performance of the Antibody Prevalence in Epilepsy and Encephalopathy (APE2) score relative to clinician‐adjudicated autoimmune encephalitis (AE) and the Graus criteria in a tertiary neuroimmunology referral cohort, including antibody‐negative AE.
Bijoya Basu, Sophia F. Damman, Samhitha M. Rai, Hesham Abboud   +3 more
wiley   +1 more source

Clinical Trials Unit Newsletter - Issue 01 [PDF]

What\u27s inside this issue: AKU receives JCIA reaccreditation - Clinical Trials Unit rejoice Director’s Message Informative Snippets AKU Site Surpasses Target Sample Size in the D-LIVR Global Trial Clinical Trials Unit celebrates World Pharmacists Day ...
Clinical Trials Unit (CTU),
core   +1 more source