Results 91 to 100 of about 71,888 (256)
Advanced Science, EarlyView.Herein we report a boron‐based pyrazole, (Borsantrazole ‐ a small molecule that selectively targets oxidative stress) that significantly increases survival, reduces weight loss, delays disease onset, and affects global protein changes in the SOD1‐G37R mouse model of ALS.
Nitesh Sanghai +9 more
wiley +1 more source
A National Strategy to Develop Pragmatic Clinical Trials Infrastructure
Clinical and Translational Science, 2014 An important challenge in comparative effectiveness research is the lack of infrastructure to support pragmatic clinical trials, which compare interventions in usual practice settings and subjects.
Thomas W. Concannon +10 more
doaj +1 more source
Advanced Science, EarlyView.Systemic platelet factor 4 (PF4) is significantly depleted in amyotrophic lateral sclerosis (ALS). Peripheral PF4 replenishment restores central proteostasis by driving OPTN‐dependent, PINK1‐independent selective autophagy in motor neurons. This intervention effectively clears toxic SOD1 aggregates, blunts glial activation, and preserves neuromuscular ...
Qingjian Xie +12 more
wiley +1 more source
Metabolic Memory in Cardiovascular Disease: Encoding, Propagation, and Therapeutic Targeting
Advanced Science, EarlyView.Cardiovascular risk often persists after metabolic abnormalities are corrected. This conceptual Review frames such persistence as metabolic memory, encoded through a narrowing therapeutic window from reversible marks to irreversible damage, with continuous input from peripheral organs.
Cheng Cheng +12 more
wiley +1 more source
AGING MEDICINE, EarlyView.The Setting Standards for Elderly Hospice Care Wards are crucial for meeting urgent elderly patient needs, enhancing hospice care quality, and advancing China's humanized elderly health system. This Standard specifies the configuration requirements for geriatric hospice care wards in terms of ward configuration, staffing models, age‐appropriate ...
Yinan Wu +12 more
wiley +1 more source
Agribusiness, EarlyView.ABSTRACT This paper examines the determinants of generative AI (GenAI) knowledge and usage among agricultural extension professionals. Drawing on survey data from agricultural extension personnel in Tennessee, we employ regression analyses and latent Dirichlet allocation (LDA) for topic modeling of open‐ended responses to study the knowledge and usage ...
Abdelaziz Lawani +3 more
wiley +1 more source
Annals of Gastroenterological Surgery, EarlyView.AI‐generated anatomical highlighting improved surgeons' recognition of actual ureteral injuries during laparoscopic colorectal surgery, including recognition within predefined injury time‐code windows. No significant overall improvement was observed for pancreatic injury, and incorrect adverse‐event judgments did not increase in no‐injury videos. These
Shunjin Ryu +9 more
wiley +1 more source
Cell Segmentation Beyond 2D—A Review of the State‐of‐the‐Art
Advanced Intelligent Discovery, EarlyView.Cell segmentation underpins many biological image analysis tasks, yet most deep learning methods remain limited to 2D despite the inherently 3D nature of cellular processes. This review surveys segmentation approaches beyond 2D, comparing 2.5D and fully 3D methods, analyzing 31 models and 32 volumetric datasets, and introducing a unified reference ...
Fabian Schmeisser +6 more
wiley +1 more source
A Compact Multijoint Finger Motion Sensing Module for Flexible Exoskeleton Applications
Advanced Intelligent Systems, EarlyView.Addressing the motion estimation gap in underactuated wearable electronics, a highly integrated sensor alongside a customized readout circuit is proposed. Featuring a screen‐printed layout and optimized horseshoe geometry, this design establishes an optimal feedback mechanism for flexible hand exoskeletons while eliminating wiring clutter.
Huawei Zheng +3 more
wiley +1 more source