Results 61 to 70 of about 6,158,274 (301)

A limited number of medicines pragmatic trials had potential for waived informed consent following the 2016 CIOMS ethical guidelines [PDF]

, 2019
OBJECTIVE: European regulations do not allow modification or waiver of informed consent for medicines randomized controlled trials (RCTs) where the three 2016 Council for International Organizations of Medical Sciences (CIOMS) provisions are met (consent
James, S.K., de Boer, Anthonius, Stephens, Richard, Avendaño Solà, Cristina, de Boer, Anthonius,, Avendano-Sola, C., Ioannidis, J.P.A., Stephens, Richard,, Boer, A. de, Rosendaal, F.R., Stephens, R., Ioannidis, John P. A.,, Dal-Re, Rafael,, Rosendaal, Frits R.,, Afd Pharmacoepi & Clinical Pharmacology, James, Stephan K, Pharmacoepidemiology and Clinical Pharmacology, Dal Ré, Rafael, Pa Ioannidis, John, Rosendaal, Frits R, Dal-Re, R., James, Stefan,, Avendano-Sola, Cristina,   +22 more
core   +2 more sources

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

What influences recruitment to randomised controlled trials? A review of trials funded by two UK funding agencies. [PDF]

, 2006
National Coordinating Centre for Research Methodology; Medical Research Council, UK Department of Health; Chief Scientist OfficeNot peer reviewedPublisher ...
McDonald, AM, Campbell, MK, Jonathan A Cook, Elbourne, DR, Cook, Jonathan Alistair, Francis, D, McDonald, Alison Mary, Francis, David, Knight, R.C, Knight, RC, Knight, Rosemary, McDonald, A.M, Grant, Adrian, Garcia Jo, McDonald, A, Cook, J, McDonald Alison M, Francis, David; id_orcid, McDonald, Alison M, Vikki A Entwistle, Campbell, Marion K, Rosemary C Knight, Snowdon Claire, Entwistle, V.A, Campbell, Marion K., Francis David, Entwistle, Vicky, Grant Adrian M, Knight, Rosemary C, Entwistle Vikki A, Cook, Jonathan A, Roberts, Ian, Cook, J.A, Grant, AM, Campbell, Marion, Cook, JA, Entwistle, Vikki A., Elbourne, D.R, Entwistle, Vikki, Campbell, Marion Kay, Snowdon, Claire, Grant, Adrian M, Garcia, J, David Francis, Elbourne, Diana, Diana R Elbourne, Alison M McDonald, Elbourne, Diana R., McDonald, Alison M., Roberts Ian, Elbourne, Diana R, Grant, Adrian Maxwell, Campbell Marion K, Entwistle, Vikki A, Snowdon, C, Campbell, M.K, Grant, Adrian M., Cook Jonathan A, Knight, Rosemary C., Garcia, Jo, Adrian M Grant, Ian Roberts, Entwistle, VA, Claire Snowdon, Grant, A.M, Marion K Campbell, Knight Rosemary C, Jo Garcia, Elbourne Diana R, Roberts, I, Cook, Jonathan A.   +70 more
core   +4 more sources

Sex‐Stratified Association of Regional Dopamine Transporter Binding With Disease Progression in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To clarify the clinical relevance of dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) abnormalities in amyotrophic lateral sclerosis (ALS), with a prespecified focus on sex‐stratified associations with disease progression and short‐term prognosis.
Tomoya Kawazoe, Keizo Sugaya, Kentaro Hayashi, Keiko Hino, Yasuhiro Nakata, Kota Bokuda, Toshio Shimizu, Kazushi Takahashi   +7 more
wiley   +1 more source

Improving outcomes in adult patients who self-harm—evaluating a brief psychological intervention in emergency departments (ASSURED): protocol of a randomised controlled clinical trial

Trials
Background Patients with self-harm and suicidal ideation are increasingly presenting in emergency departments (ED) in the UK. Self-harm is the strongest risk factor for suicide.
Rose McCabe, Mimi Suzuki, Sally O’Keeffe, Neil Walker, Richard Hooper, Stefan Priebe, Borislava Mihaylova, Yan Feng, Chris Dickens, Peter Aitken, Vera Araújo Soares, Richard Byng, Domenico Giacco, Navneet Kapur, Will Lee, Peter Riou, Mary Ryan, Alan Simpson, Helen Smith, Lucy Polyanna Goldsmith, Alexandra Elissavet Bakou   +20 more
doaj   +1 more source

The Adhesive Capsulitis Corticosteroid and Dilation (ACCorD) randomized controlled trial: a feasibility study in primary care

Bone & Joint Open
Aims: Is it feasible to conduct a definitive multicentre trial in community settings of corticosteroid injections (CSI) and hydrodilation (HD) compared to CSI for patients with frozen shoulder?
Livio Di Mascio, Thomas Hamborg, Borislava Mihaylova, Jamila Kassam, Bina Shah, Beth Stuart, Xavier L. Griffin   +6 more
doaj   +1 more source

A Two‐Stage Questionnaire and Actigraphy Screening for iRBD in a Multicenter Retrospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid‐eye‐movement sleep behavior disorder is a prodromal marker of synucleinopathies. However, most cases remain undiagnosed due to the insufficient predictive value of questionnaires and limited access to confirmatory video‐polysomnography. We assessed a two‐stage screening strategy combining a brief questionnaire on rapid‐
Caleb A. Massimi, Giorgio Ricciardiello Mejia, Andre Metzger, Kang Hyun Ryu, Salonee Marwaha, Eva Grzegorczyk, Li Zhou, Eliana Jacobs, Boris Gilyadov, Claudia Kunney, Liqhwa Ncube, Ankit Parekh, Emmanuel Mignot, Fanny M. Elahi, Joseph Winer, Kathleen Poston, Andreas Brink‐Kjaer, Emmanuel H. During   +17 more
wiley   +1 more source

Clinical Trials Unit Newsletter - Issue 02 [PDF]

What\u27s inside this issue: The Clinical Trials Summit of Pakistan 2025 Biosimilar trials at CTU! Completion of the Panbio Self-Test Enrolment Coming Together for Better Cancer Care Informative Snippets Clinical Trials Unit celebrates Clinical Trials ...
Clinical Trials Unit (CTU),
core   +1 more source

Using systematic data categorisation to quantify the types of data collected in clinical trials: the DataCat project

Trials, 2020
Background Data collection consumes a large proportion of clinical trial resources. Each data item requires time and effort for collection, processing and quality control procedures.
Evelyn Crowley, Shaun Treweek, Katie Banister, Suzanne Breeman, Lynda Constable, Seonaidh Cotton, Anne Duncan, Adel El Feky, Heidi Gardner, Kirsteen Goodman, Doris Lanz, Alison McDonald, Emma Ogburn, Kath Starr, Natasha Stevens, Marie Valente, Gordon Fernie   +16 more
doaj   +1 more source

A pragmatic approach to summary extraction in clinical trials [PDF]

Proceedings of the HLT-NAACL BioNLP Workshop on Linking Natural Language and Biology - LNLBioNLP '06, 2006
ClinicalTrials.gov, the National Library of Medicine clinical trials registry, is a monolingual clinical research website with over 29,000 records at present. The information is presented in static and free-text fields. Static fields contain high-level informational text, descriptors, and controlled vocabularies that remain constant across all clinical
Graciela Rosemblat, Laurel Graham
openaire   +3 more sources