Results 51 to 60 of about 6,158,274 (301)

The impact of COVID-19 on pragmatic clinical trials: lessons learned from the NIH Health Care Systems Research Collaboratory

Trials, 2022
Background The COVID-19 pandemic has considerably disrupted nearly all aspects of daily life, including healthcare delivery and clinical research. Because pragmatic clinical trials are often embedded within healthcare delivery systems, they may be at ...
Emily C. O’Brien, Jeremy Sugarman, Kevin P. Weinfurt, Eric B. Larson, Patrick J. Heagerty, Adrian F. Hernandez, Lesley H. Curtis   +6 more
doaj   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Contamination in trials of educational interventions [PDF]

, 2007
Objectives: To consider the effects of contamination on the magnitude and statistical significance (or precision) of the estimated effect of an educational intervention, to investigate the mechanisms of contamination, and to consider how contamination ...
Keogh-Brown, M.R., Bachmann, M.O., Ramsay, Craig R, Hewitt, C., Campbell, M.J., Torgerson, D.J., Miles, J.N.V., Howe, A., Shepstone, L., Elbourne, Diana R., Song, F, Harvey, I., Miles, S.   +12 more
core   +3 more sources

Thoracoscopy and talc poudrage compared with intercostal drainage and talc slurry infusion to manage malignant pleural effusion: the TAPPS RCT

Health Technology Assessment, 2020
Background: There are around 40,000 new cases of malignant pleural effusion in the UK each year. Insertion of talc slurry via a chest tube is the current standard treatment in the UK.
Rahul Bhatnagar, Ramon Luengo-Fernandez, Brennan C Kahan, Najib M Rahman, Robert F Miller, Nick A Maskell   +5 more
doaj   +1 more source

Marketing and clinical trials : a case study [PDF]

, 2007
Background: Publicly funded clinical trials require a substantial commitment of time and money. To ensure that sufficient numbers of patients are recruited it is essential that they address important questions in a rigorous manner and are managed well ...
Francis, D, Francis, David, McDonald, Alison Mary, Knight, R.C, McDonald, A.M, Garcia Jo, McDonald Alison M, Francis, David; id_orcid, McDonald, Alison M, Vikki A Entwistle, Campbell, Marion K, Rosemary C Knight, Snowdon Claire, Entwistle, V.A, Campbell, Marion K., Francis David, Grant Adrian M, Knight, Rosemary C, Haleema Shakur, Entwistle Vikki A, Roberts, Ian, Entwistle, Vikki A., Elbourne, D.R, Shakur, H, Entwistle, Vikki, Mcdonald, Alison M., Campbell, Marion Kay, Snowdon, Claire, Grant, Adrian M, Garcia, J, David Francis, Diana R Elbourne, Alison M McDonald, Elbourne, Diana R., Roberts Ian, Shakur, Haleema, Elbourne, Diana R, Grant, Adrian Maxwell, Campbell Marion K, Entwistle, Vikki A, Snowdon, C, Campbell, M.K, Shakur Haleema, Grant, Adrian M., Knight, Rosemary C., Garcia, Jo, Adrian M Grant, Ian Roberts, Claire Snowdon, Grant, A.M, Marion K Campbell, Knight Rosemary C, Jo Garcia, Elbourne Diana R, Roberts, I   +54 more
core   +4 more sources

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

Statistical analysis plan for Fluid Optimisation in Emergency Laparotomy (FLO-ELA) Trial; a multi-centre randomised trial of cardiac output-guided fluid therapy compared to usual care in patients undergoing major emergency gastrointestinal surgery

Trials
Background FLO-ELA is a multi-centre, parallel-group, open-label, randomised controlled trial (RCT) looking at the effect of minimally invasive cardiac output monitoring in the management of patients aged 50 years and above undergoing emergency ...
Neil J. Walker, Gordon Forbes, Brennan C. Kahan, Melanie Smuk, Rachel Phillips, Olivier Quintin, Kim May Lee, Mark R. Edwards   +7 more
doaj   +1 more source

Pragmatic disorders and their social impact [PDF]

, 2011
Pragmatic disorders in children and adults have been the focus of clinical investigations for approximately 40 years. In that time, clinicians and researchers have established a diverse range of pragmatic phenomena that are disrupted in these disorders ...
Louise Cummings, Cummings, L
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Partnering with social service staff to implement pragmatic clinical trials: an interim analysis of implementation strategies

Trials, 2023
Background With recent growth in the conduct of pragmatic clinical trials, the reliance on frontline staff to contribute to trial-related activities has grown as well.
Lisa A. Juckett, Kimberly P. Bernard, Kali S. Thomas   +2 more
doaj   +1 more source