Results 51 to 60 of about 71,888 (256)

The Adhesive Capsulitis Corticosteroid and Dilation (ACCorD) randomized controlled trial: a feasibility study in primary care

Bone & Joint Open
Aims: Is it feasible to conduct a definitive multicentre trial in community settings of corticosteroid injections (CSI) and hydrodilation (HD) compared to CSI for patients with frozen shoulder?
Livio Di Mascio, Thomas Hamborg, Borislava Mihaylova, Jamila Kassam, Bina Shah, Beth Stuart, Xavier L. Griffin   +6 more
doaj   +1 more source

Using systematic data categorisation to quantify the types of data collected in clinical trials: the DataCat project

Trials, 2020
Background Data collection consumes a large proportion of clinical trial resources. Each data item requires time and effort for collection, processing and quality control procedures.
Evelyn Crowley, Shaun Treweek, Katie Banister, Suzanne Breeman, Lynda Constable, Seonaidh Cotton, Anne Duncan, Adel El Feky, Heidi Gardner, Kirsteen Goodman, Doris Lanz, Alison McDonald, Emma Ogburn, Kath Starr, Natasha Stevens, Marie Valente, Gordon Fernie   +16 more
doaj   +1 more source

Sex‐Stratified Association of Regional Dopamine Transporter Binding With Disease Progression in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To clarify the clinical relevance of dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) abnormalities in amyotrophic lateral sclerosis (ALS), with a prespecified focus on sex‐stratified associations with disease progression and short‐term prognosis.
Tomoya Kawazoe, Keizo Sugaya, Kentaro Hayashi, Keiko Hino, Yasuhiro Nakata, Kota Bokuda, Toshio Shimizu, Kazushi Takahashi   +7 more
wiley   +1 more source

A pragmatic randomized trial comparing tablet computer informed consent to traditional paper-based methods for an osteoporosis study

Contemporary Clinical Trials Communications, 2016
Objective: Methods to improve informed consent efficiency and effectiveness are needed for pragmatic clinical trials. We compared informed consent using a tablet computer to a paper approach to assess comprehension and satisfaction of patients and clinic
A.H. Warriner, P.J. Foster, A. Mudano, N.C. Wright, M.E. Melton, S.E. Sattui, W. Calmbach, J.R. Curtis, M. Kilgore, C.E. Lewis, W. Pace, K.G. Saag   +11 more
doaj   +1 more source

A pragmatic approach to summary extraction in clinical trials [PDF]

Proceedings of the HLT-NAACL BioNLP Workshop on Linking Natural Language and Biology - LNLBioNLP '06, 2006
ClinicalTrials.gov, the National Library of Medicine clinical trials registry, is a monolingual clinical research website with over 29,000 records at present. The information is presented in static and free-text fields. Static fields contain high-level informational text, descriptors, and controlled vocabularies that remain constant across all clinical
Graciela Rosemblat, Laurel Graham
openaire   +3 more sources

A Two‐Stage Questionnaire and Actigraphy Screening for iRBD in a Multicenter Retrospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid‐eye‐movement sleep behavior disorder is a prodromal marker of synucleinopathies. However, most cases remain undiagnosed due to the insufficient predictive value of questionnaires and limited access to confirmatory video‐polysomnography. We assessed a two‐stage screening strategy combining a brief questionnaire on rapid‐
Caleb A. Massimi, Giorgio Ricciardiello Mejia, Andre Metzger, Kang Hyun Ryu, Salonee Marwaha, Eva Grzegorczyk, Li Zhou, Eliana Jacobs, Boris Gilyadov, Claudia Kunney, Liqhwa Ncube, Ankit Parekh, Emmanuel Mignot, Fanny M. Elahi, Joseph Winer, Kathleen Poston, Andreas Brink‐Kjaer, Emmanuel H. During   +17 more
wiley   +1 more source

Electroencephalographic Normalization as a Biomarker of Clinical Recovery in Down Syndrome Regression Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Down syndrome regression disorder is a syndrome characterized by subacute loss of cognitive, behavioral, and functional abilities in individuals with Down syndrome. Electroencephalography abnormalities are frequently observed during evaluation, but it remains unclear whether these findings represent a dynamic marker of disease ...
Jonathan D. Santoro, Mackenzie Silverman, Maeve C. Lucas, Mariam M. Yousuf, Samuel T. Otey, Stella V. Gray, Brittany Jordan, Madeline D. Kahan, Latanya D. Agurs, Michelle Van Hirtum Das, Deborah Holder, Devin King, Eileen A. Quinn, Ryan Kammeyer, Michael S. Rafii   +14 more
wiley   +1 more source

Principles and procedures for data and safety monitoring in pragmatic clinical trials

Trials, 2019
Background All clinical trial investigators have ethical and regulatory obligations to monitor participant safety and trial integrity. Specific procedures for meeting these obligations, however, may differ substantially between pragmatic trials and ...
Gregory E. Simon, Susan M. Shortreed, Rebecca C. Rossom, Robert B. Penfold, Jo Ann M. Sperl-Hillen, Patrick O’Connor   +5 more
doaj   +1 more source

Against pragmatism: on efficacy, effectiveness and the real world

Trials, 2009
Explanatory and pragmatic trials represent ends of a continuum of attitudes about clinical trial design. Recent literature argues that pragmatic trials are more informative about clinical care in the real world. Although there is place for more pragmatic
Kitsios Georgios, Kent David M
doaj   +1 more source

Group antenatal care (Pregnancy Circles) for diverse and disadvantaged women: study protocol for a randomised controlled trial with integral process and economic evaluations

BMC Health Services Research, 2020
Background Group antenatal care has been successfully implemented around the world with suggestions of improved outcomes, including for disadvantaged groups, but it has not been formally tested in the UK in the context of the NHS.
Meg Wiggins, Mary Sawtell, Octavia Wiseman, Christine McCourt, Sandra Eldridge, Rachael Hunter, Ekaterina Bordea, Connor Mustard, Ainul Hanafiah, Bethan Hatherall, Vivian Holmes, Anita Mehay, Helliner Robinson, Cathryn Salisbury, Lorna Sweeney, Kade Mondeh, Angela Harden   +16 more
doaj   +1 more source