Results 41 to 50 of about 6,158,274 (301)

What can we learn from clinical trials of anticonvulsant drugs in epilepsy?

, 2002
Any physician who intends to utilize the available antiepileptic drugs (AEDs) judiciously, cannot do so without being well versed on their pharmacological properties and the large body of evidence that is continuously accumulating on their relative ...
What Can We Learn From Clinical Trials Of Anticonvulsant Drugs In Epilepsy?, PERUCCA, EMILIO   +1 more
core   +1 more source

Financial considerations in the conduct of multi-centre randomised controlled trials: evidence from a qualitative study. [PDF]

, 2006
National Coordinating Centre for Research Methodology; Medical Research Council, UK Department of Health; Chief Scientist OfficeNot peer reviewedPublisher ...
Snowdon, Claire, Grant, Adrian M, Garcia, J, Francis, D, Francis, David, McDonald, Alison Mary, Knight, R.C, Elbourne, Diana, Knight, Rosemary, Elbourne, Diana R., McDonald, A.M, Grant, Adrian, Garcia Jo, Roberts Ian, McDonald Alison M, Elbourne, Diana R, Francis, David; id_orcid, Grant, Adrian Maxwell, McDonald, Alison M, Campbell Marion K, Entwistle, Vikki A, Snowdon, C, Campbell, Marion K, Campbell, M.K, Snowdon Claire, Entwistle, V.A, Campbell, Marion K., Francis David, Entwistle, Vicky, MacDonald, Alison M., McDonald, Alison, Grant, Adrian M., Grant Adrian M, Knight, Rosemary C, Knight, Rosemary C., Entwistle Vikki A, Roberts, Ian, Garcia, Jo, Grant, A.M, Campbell, Marion, Knight Rosemary C, Elbourne Diana R, Entwistle, Vikki A., Elbourne, D.R, Entwistle, Vikki, Campbell, Marion Kay, Roberts, I   +46 more
core   +1 more source

Evidence‐Based Clinical Practice Guidelines for the Management of Pediatric Febrile Neutropenia: Resource‐Sensitive Recommendations for the Asian Continent

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Febrile neutropenia (FN) is a frequent and serious complication in children receiving cancer therapy. Standardizing FN management across Asia is challenging due to variable healthcare infrastructure, diagnostic capacity, and infection patterns; however, it could improve resource use and patient outcomes.
Joliza Patricia Cañeba, Shweta Bansal, Tea Reljic, Allyne Montecillo‐Aguelo, Hamidah Alias, Farrah Amaranto, Maria Stella Aquino‐Calingasan, Bambang Ardianto, Eggi Arguni, Sally Blair, Thi Tam Dang, Maria Beatriz Gepte, Samanmalee Gunasekara, Andini Handayani, Miriam Kimpo, Catherine G. Lam, Nawachai Lertvivatpong, Sergio Licona, Ana Loseo, Ratha Mlis, Vivian Moreno Berrio, Nguyen Hoai Anh, Anna Lisa Ong‐Lim, Ha Thu Pham, Krishna Sagar Sharma, Bun Sereyleak, Sally Jane G. Velasco‐Aro, Su Yadana, Ambuj Kumar, Sheena Mukkada   +29 more
wiley   +1 more source

Validation of the cancer fatigue scale (CFS) in a UK population

BMC Cancer
Background Cancer-related fatigue is one of the most common symptoms in patients with cancer. Fatigue reduces health-related quality of life. The Cancer Fatigue Scale (CFS) is a brief instrument that captures the multidimensional nature of fatigue with ...
C. Robinson, G. Feder, AL Huntley, J. Ramsay, D. Varsani, D. Gangahar, M. Kröz   +6 more
doaj   +1 more source

Supported online self-management versus care as usual for symptoms of fatigue, pain and urgency/incontinence in adults with inflammatory bowel disease (IBD-BOOST): study protocol for a randomised controlled trial

Trials, 2021
Background Despite being in clinical remission, many people with inflammatory bowel disease (IBD) live with fatigue, chronic abdominal pain and bowel urgency or incontinence that limit their quality of life.
Christine Norton, Jonathan Syred, Sally Kerry, Micol Artom, Louise Sweeney, Ailsa Hart, Wladyslawa Czuber-Dochan, Stephanie J. C. Taylor, Borislava Mihaylova, Chris Roukas, Qasim Aziz, Laura Miller, Richard Pollok, Sonia Saxena, Imogen Stagg, Helen Terry, Zohra Zenasni, Lesley Dibley, Rona Moss-Morris   +18 more
doaj   +1 more source

Meeting pragmatism halfway: making a pragmatic clinical trial protocol [PDF]

Sociology of Health & Illness, 2015
AbstractPragmatic clinical trials (PCTs) are today an increasingly prominent means of measuring the ‘effectiveness’ of healthcare interventions in ‘real world’ clinical settings, in order to produce evidence on which to base regulatory and clinical decision‐making.
openaire   +3 more sources

A guide to research partnerships for pragmatic clinical trials [PDF]

BMJ, 2014
#### Summary points Pragmatic clinical trials are comparative effectiveness studies conducted in real-world settings to answer questions relevant to patients, clinicians, and healthcare decision makers. In contrast, explanatory clinical trials study how treatments or interventions work in carefully controlled settings and study populations, often to ...
Johnson, Karin E, Tachibana, Chris, Coronado, Gloria D, Dember, Laura M, Glasgow, Russell E, Huang, Susan S, Martin, Paul J, Richards, Julie, Rosenthal, Gary, Septimus, Ed, Simon, Gregory E, Solberg, Leif, Suls, Jerry, Thompson, Ella, Larson, Eric B   +14 more
openaire   +4 more sources

Assessment of outcome in clinical trials in mild Alzheimer 19s disease: urgent time for a rethink? [PDF]

, 2013
Introduction: A major barrier for clinical trials in Alzheimer's disease is the lack of sensitive clinical endpoints for the early stages. Until recently, regulatory agencies have required demonstration of improvement in two disease domains, cognition ...
McGoldrick, S., Duffy, Fiona, McGoldrick, Susan, Reynish, Emma, Kelly, Fiona, Morrison, Y., Wilson, L., Bennett, Crispin, Wilson, J T Lindsay, Bennett, C., Morrison, Yvonne, Duffy, F., Reynish, E.   +12 more
core  

Intervention description is not enough: evidence from an in-depth multiple case study on the untold role and impact of context in randomised controlled trials of seven complex interventions [PDF]

, 2012
Background: A number of single case reports have suggested that the context within which intervention studies take place may challenge the assumptions that underpin randomised controlled trials (RCTs).
Brian Williams, Williams Brian, Treweek Shaun, Shaun Treweek, Taylor, Julie; id_orcid, Coyle Joanne, Taylor, Julie, Wells, Mary, Wells Mary, Mary Wells, Coyle, Joanne, Williams, Brian, Taylor Julie, Julie Taylor, Joanne Coyle, Treweek, Shaun   +15 more
core   +2 more sources

Therapeutic Apheresis in Nigeria: A Multi‐Center Summary of Abstracts From the Inaugural Nigerian Society for Apheresis Scientific Meeting

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Therapeutic apheresis (TA) is an established treatment modality for hematologic, neurologic, and immunologic disorders, yet access remains severely limited in sub‐Saharan Africa. Donor apheresis, including platelet apheresis collection from healthy donors, represents an important complementary modality supporting blood product ...
Nosa Bazuaye, Chimezie Okwuonu, Evelyn Idam, Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Zinnah Aloziem, Blossom Amamchukwu, Patience Elimia, Mkpoikanabasi Obot‐Obot, Henry Mbakwe, Praises Maduagwuna, Olatunji Akinrodoye, Chiamaka Anyanwu, Benjamin Anyanwu, Adedamola Akinsiku, Oluwatoyin A. Akinsiku, Muzamil O. Hassan, Fatiu A. Arogundade, Olalekan E. Ojo, Homayemem Weli, Jesupelumi Adenihun, Aderemi Adelaja, Ebun Bamgboye, Olalekan Olatise, Ade E. Faponle, Ayoola Odeyemi, Michael Muoka, Stephen Asaolu, Qudrat Busari, Blessing Dawudu, Michael Naiyeju, Rasheed A. Balogun   +33 more
wiley   +1 more source