Results 41 to 50 of about 71,128 (257)

The impact of COVID-19 on pragmatic clinical trials: lessons learned from the NIH Health Care Systems Research Collaboratory

Trials, 2022
Background The COVID-19 pandemic has considerably disrupted nearly all aspects of daily life, including healthcare delivery and clinical research. Because pragmatic clinical trials are often embedded within healthcare delivery systems, they may be at ...
Emily C. O’Brien, Jeremy Sugarman, Kevin P. Weinfurt, Eric B. Larson, Patrick J. Heagerty, Adrian F. Hernandez, Lesley H. Curtis   +6 more
doaj   +1 more source

"Targeted" Consent for Pragmatic Clinical Trials [PDF]

Journal of General Internal Medicine, 2015
Research on interventions within the standard of care has enormous potential, yet it also raises several ethical and regulatory challenges. Perhaps the most important is determining what consent process is needed for these "pragmatic" clinical trials. Some argue that pragmatic clinical trials need to obtain in-depth research consent.
openaire   +2 more sources

A guide to research partnerships for pragmatic clinical trials [PDF]

BMJ, 2014
#### Summary points Pragmatic clinical trials are comparative effectiveness studies conducted in real-world settings to answer questions relevant to patients, clinicians, and healthcare decision makers. In contrast, explanatory clinical trials study how treatments or interventions work in carefully controlled settings and study populations, often to ...
Johnson, Karin E, Tachibana, Chris, Coronado, Gloria D, Dember, Laura M, Glasgow, Russell E, Huang, Susan S, Martin, Paul J, Richards, Julie, Rosenthal, Gary, Septimus, Ed, Simon, Gregory E, Solberg, Leif, Suls, Jerry, Thompson, Ella, Larson, Eric B   +14 more
openaire   +4 more sources

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Validation of the cancer fatigue scale (CFS) in a UK population

BMC Cancer
Background Cancer-related fatigue is one of the most common symptoms in patients with cancer. Fatigue reduces health-related quality of life. The Cancer Fatigue Scale (CFS) is a brief instrument that captures the multidimensional nature of fatigue with ...
C. Robinson, G. Feder, AL Huntley, J. Ramsay, D. Varsani, D. Gangahar, M. Kröz   +6 more
doaj   +1 more source

Supported online self-management versus care as usual for symptoms of fatigue, pain and urgency/incontinence in adults with inflammatory bowel disease (IBD-BOOST): study protocol for a randomised controlled trial

Trials, 2021
Background Despite being in clinical remission, many people with inflammatory bowel disease (IBD) live with fatigue, chronic abdominal pain and bowel urgency or incontinence that limit their quality of life.
Christine Norton, Jonathan Syred, Sally Kerry, Micol Artom, Louise Sweeney, Ailsa Hart, Wladyslawa Czuber-Dochan, Stephanie J. C. Taylor, Borislava Mihaylova, Chris Roukas, Qasim Aziz, Laura Miller, Richard Pollok, Sonia Saxena, Imogen Stagg, Helen Terry, Zohra Zenasni, Lesley Dibley, Rona Moss-Morris   +18 more
doaj   +1 more source

Meeting pragmatism halfway: making a pragmatic clinical trial protocol [PDF]

Sociology of Health & Illness, 2015
AbstractPragmatic clinical trials (PCTs) are today an increasingly prominent means of measuring the ‘effectiveness’ of healthcare interventions in ‘real world’ clinical settings, in order to produce evidence on which to base regulatory and clinical decision‐making.
openaire   +3 more sources

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Thoracoscopy and talc poudrage compared with intercostal drainage and talc slurry infusion to manage malignant pleural effusion: the TAPPS RCT

Health Technology Assessment, 2020
Background: There are around 40,000 new cases of malignant pleural effusion in the UK each year. Insertion of talc slurry via a chest tube is the current standard treatment in the UK.
Rahul Bhatnagar, Ramon Luengo-Fernandez, Brennan C Kahan, Najib M Rahman, Robert F Miller, Nick A Maskell   +5 more
doaj   +1 more source

Data monitoring committees for pragmatic clinical trials [PDF]

Clinical Trials, 2015
In any clinical trial, it is essential to monitor the accumulating data to be sure that the trial continues to be safe for participants and that the trial is being conducted properly. Data monitoring committees, independent expert panels who undertake regular reviews of the data as the trial progresses, serve an important role in safeguarding the ...
Ellenberg, Susan S, Culbertson, Richard, Gillen, Daniel L, Goodman, Steven, Schrandt, Suzanne, Zirkle, Maryan   +5 more
openaire   +4 more sources