Results 21 to 30 of about 71,888 (256)

Study within a trial of electronic versus paper-based Patient-Reported oUtcomes CollEction (SPRUCE): study protocol for a partially randomised patient preference study

BMJ Open, 2023
Introduction Patient-reported outcomes (PRO) are currently collected from trial participants using paper questionnaires by the Clinical Trials and Statistics Unit at The Institute of Cancer Research (ICR-CTSU).
Rebecca Lewis, Emma Hall, Jacqui Gath, Elizabeth Hill, Lara Philipps, Stephanie Foster, Deborah Gardiner, Alexa Gillman, Joanne Haviland, Diana King, Georgina Manning, Morgaine Stiles   +11 more
doaj   +1 more source

Clinical- and cost-effectiveness of a technology-supported and solution-focused intervention (DIALOG+) in treatment of patients with chronic depression—study protocol for a multi-site, cluster randomised controlled trial [TACK]

Trials, 2022
Background Many with an acute depressive disorder go on to develop chronic depression, despite ongoing care. There are few specifically designed interventions to treat chronic depression.
Philip McNamee, Aleksandra Matanov, Lauren Jerome, Sally Kerry, Neil Walker, Yan Feng, Andrew Molodynski, Shonagh Scott, Latha Guruvaiah, Sue Collinson, Rose McCabe, John Geddes, Stefan Priebe, Victoria Bird   +13 more
doaj   +1 more source

Double-blind randomised controlled trial of percutaneous tibial nerve stimulation versus sham electrical stimulation in the treatment of faecal incontinence: CONtrol of Faecal Incontinence using Distal NeuromodulaTion (the CONFIDeNT trial)

Health Technology Assessment, 2015
Background: Faecal incontinence (FI) is a common condition which is often under-reported. It is distressing for those suffering from it, impacting heavily on their quality of life.
Emma J Horrocks, Stephen A Bremner, Natasha Stevens, Christine Norton, Deborah Gilbert, P Ronan O’Connell, Sandra Eldridge, Charles H Knowles   +7 more
doaj   +1 more source

Understanding implementability in clinical trials: a pragmatic review and concept map

Trials, 2021
Background The translation of evidence from clinical trials into practice is complex. One approach to facilitating this translation is to consider the ‘implementability’ of trials as they are designed and conducted.
Miranda S. Cumpston, Steven A. Webb, Philippa Middleton, Greg Sharplin, Sally Green, for the Australian Clinical Trials Alliance Reference Group on Impact and Implementation of CTN Trials   +5 more
doaj   +1 more source

Pragmatic clinical trials

Complementary Therapies in Medicine, 2004
Both pragmatic and explanatory randomised controlled trials have a useful role to play in the evaluation of health care interventions. In this descriptive article, the key steps in conducting a pragmatic trial are described. The strengths and limitations of pragmatic trials are also discussed.
openaire   +2 more sources

Stepped-wedge randomised trial of laparoscopic ventral mesh rectopexy in adults with chronic constipation: study protocol for a randomized controlled trial

Trials, 2018
Background Laparoscopic ventral mesh rectopexy (LVMR) is an established treatment for external full-thickness rectal prolapse. However, its clinical efficacy in patients with internal prolapse is uncertain due to the lack of high-quality evidence ...
Ugo Grossi, Natasha Stevens, Eleanor McAlees, Jon Lacy-Colson, Steven Brown, Anthony Dixon, Gian Luca Di Tanna, S. Mark Scott, Christine Norton, Nadine Marlin, James Mason, Charles H. Knowles, On behalf of the NIHR CapaCiTY working group   +12 more
doaj   +1 more source

"Targeted" Consent for Pragmatic Clinical Trials [PDF]

Journal of General Internal Medicine, 2015
Research on interventions within the standard of care has enormous potential, yet it also raises several ethical and regulatory challenges. Perhaps the most important is determining what consent process is needed for these "pragmatic" clinical trials. Some argue that pragmatic clinical trials need to obtain in-depth research consent.
openaire   +2 more sources

Physicians’ perspectives regarding pragmatic clinical trials [PDF]

Journal of Comparative Effectiveness Research, 2016
Aim: Practicing physicians inevitably become involved in pragmatic clinical trials (PCTs), including comparative effectiveness research. We sought to identify physicians’ perspectives related to PCTs. Methods: In-depth semistructured interviews with 20 physicians in the USA. Results:
Rachel, Topazian, Juli, Bollinger, Kevin P, Weinfurt, Rachel, Dvoskin, Debra, Mathews, Kathleen, Brelsford, Matthew, DeCamp, Jeremy, Sugarman   +7 more
openaire   +2 more sources

The need for increased pragmatism in cardiovascular clinical trials

Nature Reviews Cardiology, 2022
The majority of cardiovascular randomized controlled trials (RCTs) test interventions in selected patient populations under explicitly protocol-defined settings. Although these 'explanatory' trial designs optimize conditions to test the efficacy and safety of an intervention, they limit the generalizability of trial findings in broader clinical ...
Muhammad Shariq Usman, Harriette G. C. Van Spall, Stephen J. Greene, Ambarish Pandey, Darren K. McGuire, Ziad A. Ali, Robert J. Mentz, Gregg C. Fonarow, John A. Spertus, Stefan D. Anker, Javed Butler, Stefan K. James, Muhammad Shahzeb Khan   +12 more
openaire   +4 more sources

Pragmatic clinical trials embedded in healthcare systems: generalizable lessons from the NIH Collaboratory

BMC Medical Research Methodology, 2017
Background The clinical research enterprise is not producing the evidence decision makers arguably need in a timely and cost effective manner; research currently involves the use of labor-intensive parallel systems that are separate from clinical care ...
Kevin P. Weinfurt, Adrian F. Hernandez, Gloria D. Coronado, Lynn L. DeBar, Laura M. Dember, Beverly B. Green, Patrick J. Heagerty, Susan S. Huang, Kathryn T. James, Jeffrey G. Jarvik, Eric B. Larson, Vincent Mor, Richard Platt, Gary E. Rosenthal, Edward J. Septimus, Gregory E. Simon, Karen L. Staman, Jeremy Sugarman, Miguel Vazquez, Douglas Zatzick, Lesley H. Curtis   +20 more
doaj   +1 more source