Results 21 to 30 of about 71,128 (257)

Effectiveness of group arts therapies (art therapy, dance movement therapy and music therapy) compared to group counselling for diagnostically heterogeneous psychiatric community patients: study protocol for a randomised controlled trial in mental health services (the ERA study)

Trials, 2023
Background Arts therapies are widely but inconsistently provided in community mental health. Whilst they are appealing to patients, evidence for their effectiveness is mixed. Trials to date have been limited to one art-form or diagnosis.
Catherine E. Carr, Emma Medlicott, Richard Hooper, Yan Feng, Borislava Mihaylova, Stefan Priebe   +5 more
doaj   +1 more source

Increasing patient participation in oncology clinical trials

Cancer Medicine, 2023
Aim Timely recruitment of eligible participants is essential for the success of clinical trials, with insufficient accrual being the leading cause for premature termination of both oncology and non‐oncology trials.
Jie Chen, Ying Lu, Shivaani Kummar
doaj   +1 more source

A comparison of approaches for adjudicating outcomes in clinical trials

Trials, 2017
Background Incorrect classification of outcomes in clinical trials can lead to biased estimates of treatment effect and reduced power. Ensuring appropriate adjudication methods to minimize outcome misclassification is therefore essential. While there are
Brennan C. Kahan, Brian Feagan, Vipul Jairath   +2 more
doaj   +1 more source

Sequence balance minimisation: minimising with unequal treatment allocations

Trials, 2017
Background Minimisation ensures excellent balance between groups for several prognostic factors, even in small samples. However, its use with unequal allocation ratios has been problematic.
Vichithranie W. Madurasinghe
doaj   +1 more source

Outcome pre-specification requires sufficient detail to guard against outcome switching in clinical trials: a case study

Trials, 2018
Background Pre-specification of outcomes is an important tool to guard against outcome switching in clinical trials. However, if the outcome is not sufficiently clearly defined, then different definitions could be applied and analysed, with only the most
Brennan C. Kahan, Vipul Jairath
doaj   +1 more source

A comparison of methods to adjust for continuous covariates in the analysis of randomised trials

BMC Medical Research Methodology, 2016
Background Although covariate adjustment in the analysis of randomised trials can be beneficial, adjustment for continuous covariates is complicated by the fact that the association between covariate and outcome must be specified.
Brennan C. Kahan, Helen Rushton, Tim P. Morris, Rhian M. Daniel   +3 more
doaj   +1 more source

Stakeholder perspectives regarding pragmatic clinical trial collateral findings

Learning Health Systems, 2021
Context Pragmatic clinical trials (PCTs), which are becoming widespread since they are relatively inexpensive and offer important benefits for healthcare decision‐making, can also present practical, ethical, and legal challenges.
Stephanie R. Morain, Debra J. H. Mathews, Kevin Weinfurt, Elizabeth May, Juli M. Bollinger, Gail Geller, Jeremy Sugarman   +6 more
doaj   +1 more source

Study within a trial of electronic versus paper-based Patient-Reported oUtcomes CollEction (SPRUCE): study protocol for a partially randomised patient preference study

BMJ Open, 2023
Introduction Patient-reported outcomes (PRO) are currently collected from trial participants using paper questionnaires by the Clinical Trials and Statistics Unit at The Institute of Cancer Research (ICR-CTSU).
Rebecca Lewis, Emma Hall, Jacqui Gath, Elizabeth Hill, Lara Philipps, Stephanie Foster, Deborah Gardiner, Alexa Gillman, Joanne Haviland, Diana King, Georgina Manning, Morgaine Stiles   +11 more
doaj   +1 more source

Clinical- and cost-effectiveness of a technology-supported and solution-focused intervention (DIALOG+) in treatment of patients with chronic depression—study protocol for a multi-site, cluster randomised controlled trial [TACK]

Trials, 2022
Background Many with an acute depressive disorder go on to develop chronic depression, despite ongoing care. There are few specifically designed interventions to treat chronic depression.
Philip McNamee, Aleksandra Matanov, Lauren Jerome, Sally Kerry, Neil Walker, Yan Feng, Andrew Molodynski, Shonagh Scott, Latha Guruvaiah, Sue Collinson, Rose McCabe, John Geddes, Stefan Priebe, Victoria Bird   +13 more
doaj   +1 more source

Double-blind randomised controlled trial of percutaneous tibial nerve stimulation versus sham electrical stimulation in the treatment of faecal incontinence: CONtrol of Faecal Incontinence using Distal NeuromodulaTion (the CONFIDeNT trial)

Health Technology Assessment, 2015
Background: Faecal incontinence (FI) is a common condition which is often under-reported. It is distressing for those suffering from it, impacting heavily on their quality of life.
Emma J Horrocks, Stephen A Bremner, Natasha Stevens, Christine Norton, Deborah Gilbert, P Ronan O’Connell, Sandra Eldridge, Charles H Knowles   +7 more
doaj   +1 more source