Results 11 to 20 of about 6,158,274 (301)
Understanding implementability in clinical trials: a pragmatic review and concept map
Trials, 2021 Background The translation of evidence from clinical trials into practice is complex. One approach to facilitating this translation is to consider the ‘implementability’ of trials as they are designed and conducted.
Miranda S. Cumpston +5 more
doaj +3 more sources
Data monitoring committees for pragmatic clinical trials [PDF]
Clinical Trials, 2015 In any clinical trial, it is essential to monitor the accumulating data to be sure that the trial continues to be safe for participants and that the trial is being conducted properly. Data monitoring committees, independent expert panels who undertake regular reviews of the data as the trial progresses, serve an important role in safeguarding the ...
Ellenberg, Susan S +5 more
openaire +6 more sources
Trials, 2023 Background Arts therapies are widely but inconsistently provided in community mental health. Whilst they are appealing to patients, evidence for their effectiveness is mixed. Trials to date have been limited to one art-form or diagnosis.
Catherine E. Carr +5 more
doaj +1 more source
Increasing patient participation in oncology clinical trials
Cancer Medicine, 2023 Aim Timely recruitment of eligible participants is essential for the success of clinical trials, with insufficient accrual being the leading cause for premature termination of both oncology and non‐oncology trials.
Jie Chen, Ying Lu, Shivaani Kummar
doaj +1 more source
A comparison of approaches for adjudicating outcomes in clinical trials
Trials, 2017 Background Incorrect classification of outcomes in clinical trials can lead to biased estimates of treatment effect and reduced power. Ensuring appropriate adjudication methods to minimize outcome misclassification is therefore essential. While there are
Brennan C. Kahan +2 more
doaj +1 more source
Does it matter if clinicians recruiting for a trial don't understand what the trial is really about? Qualitative study of surgeons' experiences of participation in a pragmatic multi-centre RCT [PDF]
, 2007 Background Qualitative methods are increasingly used to study the process of clinical trials and patients understanding of the rationale for trials, randomisation and reasons for taking part or refusing.
Snowdon, Claire +25 more
core +4 more sources
Sequence balance minimisation: minimising with unequal treatment allocations
Trials, 2017 Background Minimisation ensures excellent balance between groups for several prognostic factors, even in small samples. However, its use with unequal allocation ratios has been problematic.
Vichithranie W. Madurasinghe
doaj +1 more source
Trials, 2018 Background Pre-specification of outcomes is an important tool to guard against outcome switching in clinical trials. However, if the outcome is not sufficiently clearly defined, then different definitions could be applied and analysed, with only the most
Brennan C. Kahan, Vipul Jairath
doaj +1 more source
A comparison of methods to adjust for continuous covariates in the analysis of randomised trials
BMC Medical Research Methodology, 2016 Background Although covariate adjustment in the analysis of randomised trials can be beneficial, adjustment for continuous covariates is complicated by the fact that the association between covariate and outcome must be specified.
Brennan C. Kahan +3 more
doaj +1 more source
Stakeholder perspectives regarding pragmatic clinical trial collateral findings
Learning Health Systems, 2021 Context Pragmatic clinical trials (PCTs), which are becoming widespread since they are relatively inexpensive and offer important benefits for healthcare decision‐making, can also present practical, ethical, and legal challenges.
Stephanie R. Morain +6 more
doaj +1 more source