Results 31 to 40 of about 71,888 (256)

Fluid Optimisation in Emergency Laparotomy (FLO-ELA) Trial: study protocol for a multi-centre randomised trial of cardiac output-guided fluid therapy compared to usual care in patients undergoing major emergency gastrointestinal surgery

Trials, 2023
Introduction Postoperative morbidity and mortality in patients undergoing major emergency gastrointestinal surgery are a major burden on healthcare systems.
Mark R. Edwards, Gordon Forbes, Neil Walker, Dion G. Morton, Monty G. Mythen, Dave Murray, Iain Anderson, Borislava Mihaylova, Ann Thomson, Matt Taylor, Marianne Hollyman, Rachel Phillips, Keith Young, Brennan C. Kahan, Rupert M. Pearse, Michael P. W. Grocott, for the FLO-ELA investigators   +16 more
doaj   +1 more source

Pros and cons of pragmatic clinical trials

Journal of Comparative Effectiveness Research, 2013
Traditional randomized controlled trials are the ‘gold standard’ for evaluating health interventions and are typically designed to maximize internal validity, often at the cost of limited generalizability. Pragmatic randomized controlled trials should be designed with a conscious effort to generate evidence with a greater external validity by making ...
Jon D, Lurie, Tamara S, Morgan
openaire   +2 more sources

Ethics and Collateral Findings in Pragmatic Clinical Trials [PDF]

The American Journal of Bioethics, 2020
Pragmatic clinical trials (PCTs) offer important benefits, such as generating evidence that is suited to inform real-world health care decisions and increasing research efficiency. However, PCTs also present ethical challenges. One such challenge involves the management of information that emerges in a PCT that is unrelated to the primary research ...
Stephanie R. Morain, Kevin Weinfurt, Juli Bollinger, Gail Geller, Debra JH Mathews, Jeremy Sugarman   +5 more
openaire   +2 more sources

Therapeutic Apheresis in Nigeria: A Multi‐Center Summary of Abstracts From the Inaugural Nigerian Society for Apheresis Scientific Meeting

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Therapeutic apheresis (TA) is an established treatment modality for hematologic, neurologic, and immunologic disorders, yet access remains severely limited in sub‐Saharan Africa. Donor apheresis, including platelet apheresis collection from healthy donors, represents an important complementary modality supporting blood product ...
Nosa Bazuaye, Chimezie Okwuonu, Evelyn Idam, Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Zinnah Aloziem, Blossom Amamchukwu, Patience Elimia, Mkpoikanabasi Obot‐Obot, Henry Mbakwe, Praises Maduagwuna, Olatunji Akinrodoye, Chiamaka Anyanwu, Benjamin Anyanwu, Adedamola Akinsiku, Oluwatoyin A. Akinsiku, Muzamil O. Hassan, Fatiu A. Arogundade, Olalekan E. Ojo, Homayemem Weli, Jesupelumi Adenihun, Aderemi Adelaja, Ebun Bamgboye, Olalekan Olatise, Ade E. Faponle, Ayoola Odeyemi, Michael Muoka, Stephen Asaolu, Qudrat Busari, Blessing Dawudu, Michael Naiyeju, Rasheed A. Balogun   +33 more
wiley   +1 more source

Supported online self-management versus care as usual for symptoms of fatigue, pain and urgency/incontinence in adults with inflammatory bowel disease (IBD-BOOST): study protocol for a randomised controlled trial

Trials, 2021
Background Despite being in clinical remission, many people with inflammatory bowel disease (IBD) live with fatigue, chronic abdominal pain and bowel urgency or incontinence that limit their quality of life.
Christine Norton, Jonathan Syred, Sally Kerry, Micol Artom, Louise Sweeney, Ailsa Hart, Wladyslawa Czuber-Dochan, Stephanie J. C. Taylor, Borislava Mihaylova, Chris Roukas, Qasim Aziz, Laura Miller, Richard Pollok, Sonia Saxena, Imogen Stagg, Helen Terry, Zohra Zenasni, Lesley Dibley, Rona Moss-Morris   +18 more
doaj   +1 more source

Pragmatic Clinical Trials in CKD: Opportunities and Challenges [PDF]

Journal of the American Society of Nephrology, 2016
Randomized controlled trials in CKD lag in number behind those of other chronic diseases, despite the high morbidity and mortality experienced by patients with kidney disease and the exorbitant costs of their health care. Observational studies of CKD frequently yield seemingly paradoxic associations of traditional risk factors with outcomes, making it ...
Ian H, de Boer, Csaba P, Kovesdy, Sankar D, Navaneethan, Carmen A, Peralta, Delphine S, Tuot, Miguel A, Vazquez, Deidra C, Crews   +6 more
openaire   +2 more sources

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Validation of the cancer fatigue scale (CFS) in a UK population

BMC Cancer
Background Cancer-related fatigue is one of the most common symptoms in patients with cancer. Fatigue reduces health-related quality of life. The Cancer Fatigue Scale (CFS) is a brief instrument that captures the multidimensional nature of fatigue with ...
C. Robinson, G. Feder, AL Huntley, J. Ramsay, D. Varsani, D. Gangahar, M. Kröz   +6 more
doaj   +1 more source

The impact of COVID-19 on pragmatic clinical trials: lessons learned from the NIH Health Care Systems Research Collaboratory

Trials, 2022
Background The COVID-19 pandemic has considerably disrupted nearly all aspects of daily life, including healthcare delivery and clinical research. Because pragmatic clinical trials are often embedded within healthcare delivery systems, they may be at ...
Emily C. O’Brien, Jeremy Sugarman, Kevin P. Weinfurt, Eric B. Larson, Patrick J. Heagerty, Adrian F. Hernandez, Lesley H. Curtis   +6 more
doaj   +1 more source

Meeting pragmatism halfway: making a pragmatic clinical trial protocol [PDF]

Sociology of Health & Illness, 2015
AbstractPragmatic clinical trials (PCTs) are today an increasingly prominent means of measuring the ‘effectiveness’ of healthcare interventions in ‘real world’ clinical settings, in order to produce evidence on which to base regulatory and clinical decision‐making.
openaire   +3 more sources