Results 111 to 120 of about 1,577,570 (335)

Prevalence of Systemic Lupus Erythematosus in Australia, 2010–2022: A Population‐Based Study Using Linked National Administrative Health Data

Arthritis Care &Research, Accepted Article.
Objectives Systemic lupus erythematosus (SLE) is a heterogenous inflammatory condition, with widely varying global prevalence estimates. Frequency of SLE in the general population of Australia has been reported to be notably lower than contemporary estimates in countries such as the US or UK at 19‐39 per 100,000 as opposed to 65‐97 per 100,000.
Lucinda Roper, Rachel Black, Joanna Tieu, Winnie Chen, Matthew Parker, Catherine Hill, Natasha Nassar, Mandana Nikpour   +7 more
wiley   +1 more source

A roadmap to develop dementia research capacity and capability in Pakistan: a model for low- and middle-income countries [PDF]

, 2019
Objective To produce a strategic roadmap for supporting the development of dementia research in Pakistan. Background While global research strategies for dementia research already exist, none is tailored to the specific needs and challenges of low ...
Ambily Sathish, Anna Daniel, Asad Tamizudin, Aysha Khaliq, Hussain Jafri, Iracema Leroi, Mohammad Wasay, Mohammed Jafri, Mowadat Hussain Rana, Murad Khan, Nasim Chaudhry, Nicolas Farina, Nusrat Husain, Pakistan Dementia Research Stakeholder Group (PDRSG), Quratulain Khan, Raheel Karim, Rakhshi Memon, Ross Dunne, Sadaf Eitesam, Saima Eman, Saima Nafis, Saima Sheikh, Salman Karim, Sana‐e‐Zehra Haidry, Sehrish Tofique, Shakil Jehangir Malik, Tayyeba Kiran, Yasser Abbasi, Zainab Zadeh   +28 more
core   +1 more source

Setting priorities to inform assessment of care homes’ readiness to participate in healthcare innovation: a systematic mapping review and consensus process [PDF]

, 2020
© 2020 The Author(s). This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly citedOrganisational ...
Bunn, F., Corazzini, K., Dening, T., Goodman, C., Gordon, A. L., Handley, M., Lynch, J, Meyer, J., Sharpe, R.   +8 more
core   +4 more sources

Pragmatic Clinical Trials in CKD: Opportunities and Challenges [PDF]

Journal of the American Society of Nephrology, 2016
Randomized controlled trials in CKD lag in number behind those of other chronic diseases, despite the high morbidity and mortality experienced by patients with kidney disease and the exorbitant costs of their health care. Observational studies of CKD frequently yield seemingly paradoxic associations of traditional risk factors with outcomes, making it ...
Ian H, de Boer, Csaba P, Kovesdy, Sankar D, Navaneethan, Carmen A, Peralta, Delphine S, Tuot, Miguel A, Vazquez, Deidra C, Crews   +6 more
openaire   +2 more sources

Seasonal patterns of oral antihistamine and intranasal corticosteroid purchases from Australian community pharmacies : a retrospective observational study [PDF]

, 2017
Acknowledgments The abstract of this paper was presented at the Respiratory Effectiveness Group 2016 Annual Summit as a poster presentation with interim findings.
Bosnic-Anticevich, Sinthia Z, Carney, A. Simon, Carter, Victoria, Christian, Louise, Durieux, Alice M. S., Harvey, Richard, Kritikos, Vicky, Price, David B., Skinner, Derek A., Smith, Pete K.   +9 more
core   +3 more sources

Model‐Driven Optimization of Subcutaneous Polymer Prodrugs Achieves Cancer Remission in Mice

Advanced Healthcare Materials, EarlyView.
A pharmacokinetics/pharmacodynamics (PK/PD) model was developed to evaluate multiple dosing regimens for subcutaneously administered water‐soluble polymer prodrug for cancer therapy. The model enabled prediction of in vivo performance and contributed to the optimization of anticancer efficacy.
Anne Rodallec, Randy Lee, Jingming Cao, Sophie Marolleau, Julien Nicolas, Sébastien Benzekry   +5 more
wiley   +1 more source

Miglustat as a Treatment for Adults with Tangier Disease Neuropathy: The MUSTANG N-of-1 Trial with 21 months Clinical Observation

Neurology and Therapy
Importance Tangier disease (TD) is an ultra-rare disease, characterised by progressive peripheral neuropathy with no established treatment. Objectives To determine whether miglustat improved the clinical status of a single patient with TD, and to ...
Andrew Cook, Beth Stuart, Antonio Ochoa-Ferraro, Nicola Condon, Megan Lawrence, Fran Webley, Kerri-Lee Wallom, Claire Forbes, Vishy Veeranna, Subadra Wanninayake, Tom Oliver, Nicholas Davies, Charlotte Dawson, Frances Platt, Tarekegn Geberhiwot   +14 more
doaj   +1 more source

FIRE (facilitating implementation of research evidence) : a study protocol [PDF]

, 2012
Research evidence underpins best practice, but is not always used in healthcare. The Promoting Action on Research Implementation in Health Services (PARIHS) framework suggests that the nature of evidence, the context in which it is used, and whether ...
A Donner, A Kitson, A Kitson, Agency for Health Research and Quality, Alison Kitson, Angie Titchen, Ann Catrine Eldh, B McCormack, B McCormack, Brendan McCormack, C Bahtsevani, CA Estabrooks, Carole A Estabrooks, Carole Mockford, CD Helfrich, CE DuBeau, Claire Hawkes, D Brown, D Lewis, DL Patrick, DM Doran, DS Thompson, EuroQoL, EuroQoL Group, G Harvey, Geraldine McCarthy, Gill Harvey, HA Glick, J Medves, J Rycroft-Malone, J Rycroft-Malone, J Rycroft-Malone, J Rycroft-Malone, J Thor, JE Squires, JM Holroyd-Leduc, Jo Rycroft-Malone, JP Spradley, K Cox, Karen Cox, Kate Seers, L Vale, L Wallin, Lars Wallin, M Eccles, M Hulscher, M Rawlins, M Rhydderch, M Sandelowski, M Schuster, Nicola J Crichton, Pat Linck, R Grol, R Grol, R Pawson, R Wiechula, Rhiannon Tudor Edwards, RT Edwards, S Dopson, S Hanney, S Hardy, S Kunz, S Majumdar, S Tsai, T Greenhalgh, T Ibbotsen, T Weijden Van der, TA Sheldon, TH Wagner   +68 more
core   +7 more sources

Addressing guideline and policy changes during pragmatic clinical trials

Clinical Trials, 2019
While conducting a set of large-scale multi-site pragmatic clinical trials involving high-impact public health issues such as end-stage renal disease, opioid use, and colorectal cancer, there were substantial changes to both policies and guidelines ...
L. Curtis, L. Dember, M. Vazquez, David M Murray, L. DeBar, Karen L. Staman, E. Septimus, V. Mor, A. Volandes, Barbara L. Wells, Susan S. Huang, B. Green, G. Coronado, C. Meyers, L. Tuzzio, Adrian F Hernandez, J. Sugarman   +16 more
semanticscholar   +1 more source

Gut Microbiota‐Derived Anandamide Mediates the Therapeutic Effects of Urolithin A on Alcohol‐Induced Cognitive and Social Dysfunction via CB1R‐DRD2‐RAP1 Signaling Axis

Advanced Science, EarlyView.
This study reveals that Urolithin A (UA) counteracts alcohol‐induced cognitive and social dysfunction (AICSD) via a gut microbiome‐dependent mechanism. UA‐enriched Bacteroids sartorii and Parabacteroids distasonis elevate anandamide (AEA), which activates the CB1R‐DRD2‐Rap1 signaling cascade to drive synaptic repair and reduce neuroinflammation ...
Hongbo Zhang, Zibin Li, Yao Xiao, Ji Bian, Caian He, Chao Liu, Lan Gong, Lin Han, Zhigang Liu, Min Wang   +9 more
wiley   +1 more source