Results 141 to 150 of about 1,577,570 (335)

A pragmatic patient-reported outcome strategy for rare disease clinical trials: application of the EORTC item library to myelodysplastic syndromes, chronic myelomonocytic leukemia, and acute myeloid leukemia. [PDF]

, 2019
BackgroundNovel, pragmatic, patient-centered strategies are needed to ensure fit-for-purpose patient-reported outcomes (PRO) instruments in clinical trial research for rare diseases such as myelodysplastic syndromes (MDS), acute myeloid leukemia (AML ...
Bejar, Rafael, Bell, Jill A, Cano, Stefan, Faller, Douglas V, Fram, Robert J, Galaznik, Aaron, Marquis, Patrick, Pompilus, Farrah, Scipione, Fatima, Strzok, Sara   +9 more
core  

A Randomized Controlled Trial of a Play-Based, Peer-Mediated Pragmatic Language Intervention for Children With Autism [PDF]

, 2019
Purpose: This randomized controlled trial evaluated the effectiveness of a play-based pragmatic language intervention for children with autism. Methods: A sample of 71 children with autism were randomized to an intervention-first group (n = 28 analyzed ...
Cordier, Reinie, Joosten, Annette, Munro, Natalie, Parsons, Lauren   +3 more
core   +3 more sources

Design and implementation of pragmatic clinical trials using the electronic medical record and an adaptive design

JAMIA Open, 2018
Objectives To demonstrate the feasibility of pragmatic clinical trials comparing the effectiveness of treatments using the electronic medical record (EMR) and an adaptive assignment design.
K. Simon, Samuel Tideman, Laura Hillman, Rebekah Lai, Raman Jathar, Yuan Ji, Stuart Bergman‐Bock, J. Castle, Tiffani Franada, T. Freedom, R. Marcus, Angela Mark, Steven Meyers, Susan Rubin, Irene Semenov, Chad J. Yucus, Anna Pham, Lisette Garduno, Monika Szela, R. Frigerio, D. Maraganore   +20 more
semanticscholar   +1 more source

“And in some cases, we're the best option:” A qualitative study of community‐based doula support for black perinatal mental health

American Journal of Community Psychology, EarlyView.
Abstract We explored community‐based doulas' perspectives on the acceptability of using formal screening tools to address low rates of mental health screening, diagnosis, and treatment for perinatal anxiety and depression among Black women. Using thematic analysis, we analyzed interview data from 30 community‐based doulas who support Black families ...
Tamara Nelson, Naysha N. Shahid, Samrawit B. Gebretensay, Chareina C. Johnson, Penny D. Telesford, Karen Sheffield‐Abdullah   +5 more
wiley   +1 more source

Determining the minimal important change of the recap of atopic eczema (RECAP) instrument in clinical trials

Skin Health and Disease
Background The Recap of atopic eczema (RECAP) is a patient‐reported instrument designed to assess eczema control. There is a lack of evidence on the interpretability of change scores in clinical trials.
Arabella Baker, Beth Stuart, Laura Howells, Eleanor J. Mitchell, Kim S. Thomas   +4 more
doaj   +1 more source

Facilitating Expedited Drug Approval– the Past, Present, and Future of Clinical Trials for Pediatric Rheumatic Disease

Arthritis Care &Research, Accepted Article.
Pamela F. Weiss, Hermine I. Brunner
wiley   +1 more source

Collaborating with transnational families: Learning from the experiences of family caretakers, educators, psychologists, and spiritual leaders in Honduras

American Journal of Community Psychology, EarlyView.
Abstract This manuscript centers on the experiences of caretakers of minors in Honduran transnational families (TNFs) in which one or both parents emigrated, and of the schoolteachers, professional psychologists, and spiritual leaders working with these families.
Marco Gemignani, Yolanda Hernández‐Albújar, Nerea Larrinaga‐Bidegain   +2 more
wiley   +1 more source

Does bariatric surgery prior to total hip or knee arthroplasty reduce post-operative complications and improve clinical outcomes for obese patients? Systematic review and meta-analysis. [PDF]

, 2016
AIMS: Our aim was to determine whether, based on the current literature, bariatric surgery prior to total hip (THA) or total knee arthroplasty (TKA) reduces the complication rates and improves the outcome following arthroplasty in obese patients. METHODS:
Aboelmagd, T, Hing, CB, MacGregor, A, Smith, TO   +3 more
core   +1 more source

High-sensitivity C-reactive protein is associated with altered cardiac structure and function in psoriasis: The PSOCADIA study

International Journal of Cardiology: Heart & Vasculature
Background: High sensitivity C-reactive protein (hsCRP) is a biomarker of systemic inflammation that may be associated with cardiovascular risk in psoriasis.
Maria Dons, Morten Sengeløv, Kristoffer Grundtvig Skaarup, Niklas Dyrby Johansen, Mats C.H. Lassen, Sofie Bøgh-Sørensen, Julie I.H. Borchsenius, Filip Soeskov Davidovski, Nino E. Landler, Christoffer V. Nissen, Peter Riis Hansen, Brittany N. Weber, Claus Zachariae, Lone Skov, Tor Biering-Sørensen   +14 more
doaj   +1 more source

A National Strategy to Develop Pragmatic Clinical Trials Infrastructure

Clinical and Translational Science, 2014
An important challenge in comparative effectiveness research is the lack of infrastructure to support pragmatic clinical trials, which compare interventions in usual practice settings and subjects.
Thomas W. Concannon, Jeanne‐Marie Guise, Rowena J. Dolor, Paul Meissner, Sean Tunis, Jerry A. Krishnan, Wilson D. Pace, Joel Saltz, William R. Hersh, Lloyd Michener, Timothy S. Carey   +10 more
doaj   +1 more source